Structure information

V2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7R0C

SPECIES

Homo sapiens

RESOLUTION

4.730

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIADV.ABO7761

PUBLICATION DATE

Sept. 14, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
vasopressin R32 N-term polar (hydrogen bond with backbone)
vasopressin R32 N-term polar (charge-assisted hydrogen bond)
vasopressin Q96 2.61x60 TM2 Van der Waals
vasopressin Q96 2.61x60 TM2 polar (hydrogen bond)
vasopressin K100 2.65x64 TM2 polar (charge-assisted hydrogen bond)
vasopressin D103 2.68x67 TM2 Van der Waals
vasopressin F178 ECL2 Van der Waals
vasopressin F178 ECL2 hydrophobic
vasopressin W193 45.51x51 ECL2 Van der Waals
vasopressin W193 45.51x51 ECL2 hydrophobic
vasopressin A194 45.52x52 ECL2 Van der Waals
vasopressin C195 ECL2 polar (hydrogen bond with backbone)
vasopressin C195 ECL2 Van der Waals
vasopressin R202 5.35x36 TM5 polar (charge-assisted hydrogen bond)
vasopressin F287 6.51x51 TM6 hydrophobic
vasopressin F287 6.51x51 TM6 Van der Waals
vasopressin F288 6.52x52 TM6 Van der Waals
vasopressin F288 6.52x52 TM6 hydrophobic
vasopressin Q291 6.55x55 TM6 Van der Waals
vasopressin Q291 6.55x55 TM6 polar (hydrogen bond)
vasopressin Q291 6.55x55 TM6 polar (hydrogen bond with backbone)
vasopressin A294 6.58x58 TM6 Van der Waals
vasopressin A295 6.59x59 TM6 Van der Waals
vasopressin A295 6.59x59 TM6 polar (hydrogen bond with backbone)
vasopressin M311 7.39x38 TM7 polar (hydrogen bond)
vasopressin L312 7.40x39 TM7 Van der Waals
vasopressin L312 7.40x39 TM7 hydrophobic

Ligands

vasopressin

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Residue Diagrams

G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7
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ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
V2 receptor
TM2
2x60 2.61x60 Q96
2x64 2.65x64 K100
2x67 2.68x67 D103
ECL2
45x51 45.51x51 W193
45x52 45.52x52 A194
TM5
5x36 5.35x36 R202
TM6
6x51 6.51x51 F287
6x52 6.52x52 F288
6x55 6.55x55 Q291
6x58 6.58x58 A294
6x59 6.59x59 A295
TM7
7x38 7.39x38 M311
7x39 7.40x39 L312