Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7T32

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

A

PUBLICATION DATE

Aug. 10, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ZM-241385 L85 3.33x33 TM3 hydrophobic
ZM-241385 F168 45.52x52 ECL2 hydrophobic
ZM-241385 W342 6.48x48 TM6 hydrophobic
ZM-241385 L345 6.51x51 TM6 hydrophobic
ZM-241385 H346 6.52x52 TM6 aromatic (face-to-edge)
ZM-241385 H360 ECL3 polar (hydrogen bond)
ZM-241385 H360 ECL3 Van der Waals
ZM-241385 M366 7.35x34 TM7 Van der Waals
ZM-241385 M366 7.35x34 TM7 hydrophobic
ZM-241385 Y367 7.36x35 TM7 hydrophobic
ZM-241385 Y367 7.36x35 TM7 Van der Waals
ZM-241385 I370 7.39x38 TM7 Van der Waals
ZM-241385 I370 7.39x38 TM7 hydrophobic

Ligands

ZM-241385

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM3
3x33 3.33x33 L85
ECL2
45x52 45.52x52 F168
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
TM7
7x34 7.35x34 M270
7x35 7.36x35 Y271
7x38 7.39x38 I274