PDB
7T8X
Resolution
3.2 Å
Released
Jan. 25, 2023
Receptor
M2
Class
A
Species
Homo sapiens
Ligand
acetylcholine
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
acetylcholine Y104 3.33x33 TM3 hydrophobic
acetylcholine W155 4.57x57 TM4 hydrophobic
acetylcholine W400 6.48x48 TM6 hydrophobic
acetylcholine Y403 6.51x51 TM6 hydrophobic
acetylcholine Y426 7.39x38 TM7 hydrophobic
acetylcholine Y430 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R H L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P V K R ICL2ECL2 V R T V E D G E C Y I Q F F S ECL2ICL3 P V A N Q D P V S P S L V Q G R I V K P N N N N M P S S D D G L E H N K I Q N G K A P R D P V T E N C V Q G E E K E S S N D S T S V S A V A S N M R D D E I T Q D E N T V S T S L G H S K D E N S K Q T C I R I G T K T P K S D S C T P T N T T V E V V G S S G Q N G D E K Q N I V A R K I V K M T K Q P A K K ICL3ECL3 A P C I ECL3N-term M N N S T N S S N N S L A L T S P Y N-termC-term C H Y K N I G A T R C-term K T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K K D K K E K P P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K H F K K T L L M
Helix box plot — Download: PNG | SVG I N G I I T V L S L S G A V L V I F V V 1 F S L A C A D L I I G F V S M N L Y T L Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G M M I A A A W V L S F I L W A P A I 4 Y L V T M I I V P L Y F A A I A T G F T V 5 L A I L L A F I I T W A P Y N V M V L I 6 A P N I T S N I Y C L W Y G I T W V T 7

GPCRdb(A)
GPCRdb(A)
M2 receptor
TM3
3x33 3.33x33 Y104
TM4
4x57 4.57x57 W155
TM6
6x48 6.48x48 W400
6x51 6.51x51 Y403
TM7
7x38 7.39x38 Y426
7x42 7.43x42 Y430