PDB
7T8X
Resolution
3.2 Å
Released
Jan. 25, 2023
Receptor
M2
Class
A
Species
Homo sapiens
Ligand
Function
acetylcholine
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
acetylcholine D103 3.32x32 TM3 polar (charge-charge)
acetylcholine Y104 3.33x33 TM3 aromatic (pi-cation)
acetylcholine S107 3.36x36 TM3 Van der Waals
acetylcholine N108 3.37x37 TM3 Van der Waals
acetylcholine W155 4.57x57 TM4 hydrophobic
acetylcholine W400 6.48x48 TM6 aromatic (pi-cation)
acetylcholine Y403 6.51x51 TM6 Van der Waals
acetylcholine Y426 7.39x38 TM7 aromatic (pi-cation)
acetylcholine C429 7.42x41 TM7 Van der Waals
acetylcholine Y430 7.43x42 TM7 Van der Waals

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ICL1 R H L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P V K R ICL2ECL2 V R T V E D G E C Y I Q F F S ECL2ICL3 P V A N Q D P V S P S L V Q G R I V K P N N N N M P S S D D G L E H N K I Q N G K A P R D P V T E N C V Q G E E K E S S N D S T S V S A V A S N M R D D E I T Q D E N T V S T S L G H S K D E N S K Q T C I R I G T K T P K S D S C T P T N T T V E V V G S S G Q N G D E K Q N I V A R K I V K M T K Q P A K K ICL3ECL3 A P C I ECL3N-term M N N S T N S S N N S L A L T S P Y N-termC-term C H Y K N I G A T R C-term K T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K K D K K E K P P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K H F K K T L L M
Helix box plot — Download: PNG | SVG I N G I I T V L S L S G A V L V I F V V 1 F S L A C A D L I I G F V S M N L Y T L Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G M M I A A A W V L S F I L W A P A I 4 Y L V T M I I V P L Y F A A I A T G F T V 5 L A I L L A F I I T W A P Y N V M V L I 6 A P N I T S N I Y C L W Y G I T W V T 7

GPCRdb(A)
GPCRdb(A)
M2 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 Y104
3x36 3.36x36 S107
3x37 3.37x37 N108
TM4
4x57 4.57x57 W155
TM6
6x48 6.48x48 W400
6x51 6.51x51 Y403
TM7
7x38 7.39x38 Y426
7x41 7.42x41 C429
7x42 7.43x42 Y430