Structure information

M4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7V68

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-30595-Y

PUBLICATION DATE

May 11, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
iperoxo Y113 3.33x33 TM3 hydrophobic
iperoxo A203 5.46x461 TM5 polar (hydrogen bond with backbone)
iperoxo A203 5.46x461 TM5 Van der Waals
iperoxo F204 5.47x47 TM5 Van der Waals
iperoxo W413 6.48x48 TM6 Van der Waals
iperoxo W413 6.48x48 TM6 hydrophobic
iperoxo Y416 6.51x51 TM6 hydrophobic
iperoxo Y416 6.51x51 TM6 Van der Waals
iperoxo Y439 7.39x38 TM7 Van der Waals
iperoxo Y439 7.39x38 TM7 hydrophobic
iperoxo C442 7.42x41 TM7 Van der Waals
iperoxo Y443 7.43x42 TM7 Van der Waals

Ligands

iperoxo

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Residue Diagrams

I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7
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ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M4 receptor
TM3
3x33 3.33x33 Y113
TM5
5x461 5.46x461 A203
5x47 5.47x47 F204
TM6
6x48 6.48x48 W413
6x51 6.51x51 Y416
TM7
7x38 7.39x38 Y439
7x41 7.42x41 C442
7x42 7.43x42 Y443