Structure information

VPAC2 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7VQX

SPECIES

Homo sapiens

RESOLUTION

2.740

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-30041-Z

PUBLICATION DATE

May 18, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PACAP-27 E24 N-term polar (charge-assisted hydrogen bond)
PACAP-27 C25 N-term Van der Waals
PACAP-27 R26 N-term Van der Waals
PACAP-27 H28 N-term aromatic (edge-to-face)
PACAP-27 H28 N-term Van der Waals
PACAP-27 Q32 N-term Van der Waals
PACAP-27 Q32 N-term polar (hydrogen bond)
PACAP-27 I59 N-term hydrophobic
PACAP-27 I59 N-term Van der Waals
PACAP-27 V78 N-term Van der Waals
PACAP-27 V78 N-term polar (hydrogen bond with backbone)
PACAP-27 F79 N-term hydrophobic
PACAP-27 F79 N-term Van der Waals
PACAP-27 F82 N-term Van der Waals
PACAP-27 F82 N-term hydrophobic
PACAP-27 Y111 N-term Van der Waals
PACAP-27 D113 N-term polar (charge-assisted hydrogen bond)
PACAP-27 D116 1.29x29 TM1 polar (charge-assisted hydrogen bond)
PACAP-27 D116 1.29x29 TM1 polar (hydrogen bond with backbone)
PACAP-27 E117 1.30x30 TM1 Van der Waals
PACAP-27 K119 1.32x32 TM1 Van der Waals
PACAP-27 I120 1.33x33 TM1 hydrophobic
PACAP-27 I120 1.33x33 TM1 Van der Waals
PACAP-27 Y123 1.36x36 TM1 Van der Waals
PACAP-27 Y123 1.36x36 TM1 polar (hydrogen bond)
PACAP-27 V126 1.39x39 TM1 hydrophobic
PACAP-27 V126 1.39x39 TM1 Van der Waals
PACAP-27 K127 1.40x40 TM1 Van der Waals
PACAP-27 Y130 1.43x43 TM1 aromatic (edge-to-face)
PACAP-27 Y130 1.43x43 TM1 Van der Waals
PACAP-27 Y134 1.47x47 TM1 Van der Waals
PACAP-27 Y134 1.47x47 TM1 polar (hydrogen bond)
PACAP-27 R172 2.60x60 TM2 polar (charge-assisted hydrogen bond)
PACAP-27 K179 2.67x67 TM2 polar (charge-assisted hydrogen bond)
PACAP-27 Y184 2.72x72 TM2 polar (hydrogen bond)
PACAP-27 Y184 2.72x72 TM2 Van der Waals
PACAP-27 Q210 3.37x37 TM3 polar (hydrogen bond)
PACAP-27 I213 3.40x40 TM3 hydrophobic
PACAP-27 I213 3.40x40 TM3 Van der Waals
PACAP-27 D273 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
PACAP-27 T274 ECL2 Van der Waals
PACAP-27 N275 ECL2 polar (hydrogen bond with backbone)
PACAP-27 N275 ECL2 Van der Waals
PACAP-27 D276 ECL2 polar (charge-assisted hydrogen bond)
PACAP-27 W281 5.36x37 TM5 Van der Waals
PACAP-27 R285 5.40x40 TM5 Van der Waals
PACAP-27 Q356 7.38x37 TM7 Van der Waals
PACAP-27 I357 7.39x38 TM7 Van der Waals
PACAP-27 I357 7.39x38 TM7 hydrophobic
PACAP-27 E360 7.42x41 TM7 polar (charge-assisted hydrogen bond)
PACAP-27 L361 7.43x42 TM7 Van der Waals
PACAP-27 L361 7.43x42 TM7 hydrophobic

Ligands

PACAP-27

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Residue Diagrams

A L S M L S V S Y G L T Y I A K V L I Y 1 L N L F L S F I L R A I S V L V K D D V 2 V L L W F F N A M I C Y Q L F V L S L K 3 C F L A Y L L G I W G L P T V C I G A W T 4 F L V F N V I I S I L I P I R I V W W P V 5 L L L I P L F G V H Y M V F A V F 6 V A V V L G Q F S G L C L E F L I Q Y 7
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ICL1 R K L H ICL1ECL1 Y S S S G T L H C P D Q P S S ECL1ICL2 M L ICL2ECL2 D T G C W D T N D ECL2ICL3 T S P D V G G ICL3ECL3 P I S I S ECL3N-term M R T L L P P A L L T C W L L A P V N S I H P E C R F H L E I Q E E E T K C A E L L R S Q T E K H K A C S G V W D N I T C W R P A N V G E T V T V P C P K V F S N F Y S K A G N I S K N C T S D G W S E T F P D F V D A C G Y S N-termC-term V C G S S F S R N G S E G A L Q F H R G S R A Q S F L Q T E T S V I C-term D P E D E S K I T F Y I L V K A I Y T L G Y S V S L M S L A T G S I I L C L F C T R N Y I H L N L F L S F I L R A I S V L V K D D V L W V G C K L S L V F L Q Y C I M A N F F W L L V E G L Y L H T L L V A P P R R C F L A Y L L I G W G L P T V C I G A W T A A R L Y L E H S V P W W V I R I P I L I S I I V N F V L F I S I I R I L L Q K L N D Q S Q Y K R L A K S T L L L I P L F G V H Y M V F A V F S K Y Q I L F E L C L G S F Q G L V V A V L Y C F L N S E L K R R C P S R D V Q C E K W R S T P S A Y R
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Residue Table


GPCRdb(A)
GPCRdb(B)
VPAC2 receptor
TM1
1x25 1.29x29 D116
1x26 1.30x30 E117
1x28 1.32x32 K119
1x29 1.33x33 I120
1x32 1.36x36 Y123
1x35 1.39x39 V126
1x36 1.40x40 K127
1x39 1.43x43 Y130
1x43 1.47x47 Y134
TM2
2x53 2.60x60 R172
2x60 2.67x67 K179
TM3
3x33 3.37x37 Q210
3x36 3.40x40 I213
ECL2
45x52 45.52x52 D273
TM5
5x41 5.36x37 W281
5x44 5.40x40 R285
TM7
7x33 7.38x37 Q356
7x34 7.39x38 I357
7x37 7.42x41 E360
7x38 7.43x42 L361