Structure information

5-HT2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WC4

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIENCE.ABL8615

PUBLICATION DATE

Jan. 26, 2022
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
5-hydroxytryptamine W151 3.28x28 TM3 aromatic (face-to-edge)
5-hydroxytryptamine D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
5-hydroxytryptamine V156 3.33x33 TM3 Van der Waals
5-hydroxytryptamine L228 45.51x51 ECL2 hydrophobic
5-hydroxytryptamine L228 45.51x51 ECL2 Van der Waals
5-hydroxytryptamine F339 6.51x51 TM6 hydrophobic
5-hydroxytryptamine F339 6.51x51 TM6 Van der Waals
5-hydroxytryptamine L362 7.35x34 TM7 Van der Waals
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 8 of 8 entries

Ligands

5-hydroxytryptamine

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Residue Diagrams

I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7
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ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 N-term C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x32 3.32x32 D155
3x33 3.33x33 V156
ECL2
45x51 45.51x51 L228
TM6
6x51 6.51x51 F339
TM7
7x34 7.35x34 L362