Structure information

GPR119

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WCM

SPECIES

Homo sapiens

RESOLUTION

2.330

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-34696-6

PUBLICATION DATE

Dec. 21, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
MBX-2982 A89 3.36x36 TM3 hydrophobic
MBX-2982 A90 3.37x37 TM3 hydrophobic
MBX-2982 V93 3.40x40 TM3 hydrophobic
MBX-2982 F157 45.52x52 ECL2 aromatic (face-to-face)
MBX-2982 L169 5.43x44 TM5 hydrophobic
MBX-2982 F174 5.48x48 TM5 hydrophobic
MBX-2982 W238 6.48x48 TM6 hydrophobic
MBX-2982 F241 6.51x51 TM6 hydrophobic
MBX-2982 E261 7.35x34 TM7 polar (charge-assisted hydrogen bond)
MBX-2982 W265 7.39x38 TM7 aromatic (face-to-face)
MBX-2982 W265 7.39x38 TM7 Van der Waals

Ligands

MBX-2982

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Residue Diagrams

T N T A I I L S A L V A L I V G F S F S 1 L N L A V A D T L I G V A I S G L L T D 2 L M V T L V S A A A S S T V F A M R L S 3 A G A C I A G L W L V S Y L I G F L P L 4 F F V F L L M A P F F G V C S L T L V F H 5 S V L I G S F A L S W T P F L I T G I V 6 L P N L L S N G V G L L W L Y R E L V 7
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ICL1 I H K N D ICL1ECL1 S P S ECL1ICL2 P F R Y L K I M ICL2ECL2 P M F Q Q T A Y K G Q C S F F A V ECL2ICL3 A M A G G Y ICL3ECL3 Q E C H L ECL3C-term G V K K V L T S F L L F L S A R N C G P E R P R E S S C H I V T I S S S E F D G C-term M E S S F S F G V I L A V L A S L I I A T N T L V A V A V L L L G V S L C F T L N L A V A D T L I G V A I S G L L T D Q L S R P T Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q S G F V A G A C I A G L W L V S Y L I G F L P L G I F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G R S P R T P S D F K A L R T V S V L I G S F A L S W T P F L I T G I V Q V A C Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E L Y H V R L Q M A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR119
TM3
3x36 3.36x36 A89
3x37 3.37x37 A90
3x40 3.40x40 V93
ECL2
45x52 45.52x52 F157
TM5
5x44 5.43x44 L169
5x48 5.48x48 F174
TM6
6x48 6.48x48 W238
6x51 6.51x51 F241
TM7
7x34 7.35x34 E261
7x38 7.39x38 W265