PDB
7YK6
Resolution
3.0 Å
Released
March 1, 2023
Receptor
RXFP4
Class
A
Species
Homo sapiens
Ligand
CHEMBL4522365
Function
Agonist
Reference
10.1038/S41467-023-36182-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4522365 E100 2.63x63 TM2 polar (charge-assisted hydrogen bond)
CHEMBL4522365 F105 ECL1 hydrophobic
CHEMBL4522365 F105 ECL1 Van der Waals
CHEMBL4522365 L118 3.29x29 TM3 Van der Waals
CHEMBL4522365 V122 3.33x33 TM3 Van der Waals
CHEMBL4522365 L192 45.51x51 ECL2 hydrophobic
CHEMBL4522365 L192 45.51x51 ECL2 Van der Waals
CHEMBL4522365 R194 ECL2 Van der Waals
CHEMBL4522365 T295 7.39x38 TM7 polar (hydrogen bond)
CHEMBL4522365 H299 7.43x42 TM7 polar (hydrogen bond)
CHEMBL4522365 H299 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R A R A P ICL1ECL1 F H W P F ECL1ICL2 A A G P G T H L ICL2ECL2 V E G E V C G V R L C L L R F P S R ECL2ICL3 Q R ICL3ECL3 V P W N S ECL3N-term M P T L N T S A S P P T F F W A N A S G G S V L S A D D A P M P V K N-termC-term L R L R L W P Q G G G W V Q Q V A L K Q V G R R W V A S N P R E S R P S T L L T N L D R G T P G C-term F L A L R L M V A L A Y G L V G A I G L L G N L A V L W V L S N C G P P S D T F V F N L A L A D L G L A L T L P F W A A E S A L D G G A L C K M V L T A T V L N V Y A S I F L I T A L S V A R Y W V V A M S L F W A R I A T L A V W A A A A L V T V P T A V F G Y W L G A Y Q L Q R V V L A F M V P L G V I T T S Y L L L L A F L Q R R R R Q D S R V V A R S V R I L V A S F F L C W F P N H V V T L W G V L V K F D L T F Y T I Q T Y V F P V T T C L A H S N S C L N P V L Y C L L R R E L A G P R Q A T F R D
Helix box plot — Download: PNG | SVG L N G L L G I A G V L G Y A L A V M L R 1 F N L A L A D L G L A L T L P F W A A E 2 A T I L F I S A Y V N L V T A T L V M K 3 A R I A T L A V W A A A A L V T V P T 4 Y S T T I V G L P V M F A L V V R Q L Q Y 5 R I L V A S F F L C W F P N H V V T L W 6 V P N L C S N S H A L C T T V P F V Y 7

GPCRdb(A)
GPCRdb(A)
RXFP4
TM2
2x63 2.63x63 E100
TM3
3x29 3.29x29 L118
3x33 3.33x33 V122
ECL2
45x51 45.51x51 L192
TM7
7x38 7.39x38 T295
7x42 7.43x42 H299