RXFP4 (rl3r2_human)

FAMILY

Class A (Rhodopsin) Peptide receptors Relaxin family peptide receptors RXFP4

GENE

RXFP4 (GPCR142, GPR100, RLN3R2)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Relaxin-3 receptor 2, RLN3 receptor 2, G-protein coupled receptor 100, G-protein coupled receptor GPCR142, Insulin-like peptide INSL5 receptor, Relaxin family peptide receptor 4

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
P
T
L
N
T
S
A
S
P
10
                   
P
T
F
F
W
A
N
A
S
G
20
                   
G
S
V
L
S
A
D
D
A
P
30
        TM1      
M
P
V
K
F
L
A
L
R
L
40
                   
M
V
A
L
A
Y
G
L
V
G
50
                   
A
I
G
L
L
G
N
L
A
V
60
                   
L
W
V
L
S
N
C
A
R
R
70
ICL1 TM2      
A
P
G
P
P
S
D
T
F
V
80
                   
F
N
L
A
L
A
D
L
G
L
90
                   
A
L
T
L
P
F
W
A
A
E
100
        ECL1    
S
A
L
D
F
H
W
P
F
G
110
TM3              
G
A
L
C
K
M
V
L
T
A
120
                   
T
V
L
N
V
Y
A
S
I
F
130
                   
L
I
T
A
L
S
V
A
R
Y
140
          ICL2  
W
V
V
A
M
A
A
G
P
G
150
      TM4        
T
H
L
S
L
F
W
A
R
I
160
                   
A
T
L
A
V
W
A
A
A
A
170
                   
L
V
T
V
P
T
A
V
F
G
180
ECL2            
V
E
G
E
V
C
G
V
R
L
190
                   
C
L
L
R
F
P
S
R
Y
W
200
TM5              
L
G
A
Y
Q
L
Q
R
V
V
210
                   
L
A
F
M
V
P
L
G
V
I
220
                   
T
T
S
Y
L
L
L
L
A
F
230
        ICL3 TM6
L
Q
R
R
Q
R
R
R
Q
D
240
                 
S
R
V
V
A
R
S
V
R
I
250
                   
L
V
A
S
F
F
L
C
W
F
260
                   
P
N
H
V
V
T
L
W
G
V
270
            ECL3
L
V
K
F
D
L
V
P
W
N
280
  TM7            
S
T
F
Y
T
I
Q
T
Y
V
290
                   
F
P
V
T
T
C
L
A
H
S
300
                   
N
S
C
L
N
P
V
L
Y
C
310
    H8            
L
L
R
R
E
P
R
Q
A
L
320
                   
A
G
T
F
R
D
L
R
L
R
330
C-term        
L
W
P
Q
G
G
G
W
V
Q
340
                   
Q
V
A
L
K
Q
V
G
R
R
350
                   
W
V
A
S
N
P
R
E
S
R
360
                   
P
S
T
L
L
T
N
L
D
R
370
       
G
T
P
G

LINKS

DIAGRAMS

ICL1 R A R A P ICL1ECL1 F H W P F ECL1ICL2 A A G P G T H L ICL2ECL2 V E G E V C G V R L C L L R F P S R ECL2ICL3 Q R ICL3ECL3 V P W N S ECL3N-term M P T L N T S A S P P T F F W A N A S G G S V L S A D D A P M P V K N-termC-term L R L R L W P Q G G G W V Q Q V A L K Q V G R R W V A S N P R E S R P S T L L T N L D R G T P G C-term F L A L R L M V A L A Y G L V G A I G L L G N L A V L W V L S N C G P P S D T F V F N L A L A D L G L A L T L P F W A A E S A L D G G A L C K M V L T A T V L N V Y A S I F L I T A L S V A R Y W V V A M S L F W A R I A T L A V W A A A A L V T V P T A V F G Y W L G A Y Q L Q R V V L A F M V P L G V I T T S Y L L L L A F L Q R R R R Q D S R V V A R S V R I L V A S F F L C W F P N H V V T L W G V L V K F D L T F Y T I Q T Y V F P V T T C L A H S N S C L N P V L Y C L L R R E L A G P R Q A T F R D
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N G L L G I A G V L G Y A L A V M L R 1 F N L A L A D L G L A L T L P F W A A E 2 A T I L F I S A Y V N L V T A T L V M K 3 A R I A T L A V W A A A A L V T V P T 4 Y S T T I V G L P V M F A L V V R Q L Q Y 5 R I L V A S F F L C W F P N H V V T L W 6 V P N L C S N S H A L C T T V P F V Y 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

PHYSIOLOGICAL LIGANDS

relaxin-3, relaxin-3 (B chain), INSL5

STRUCTURE MODELS

STRUCTURES

Found 3 structure(s) - view all details on the Structures page

PDBs: 7YJ4, 7YK6, 7YK7