Structure information

RXFP4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7YK7

SPECIES

Homo sapiens

RESOLUTION

2.750

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-36182-Z

PUBLICATION DATE

March 1, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
DC591053 W97 2.60x60 TM2 hydrophobic
DC591053 F105 ECL1 hydrophobic
DC591053 L118 3.29x29 TM3 hydrophobic
DC591053 L192 45.51x51 ECL2 hydrophobic
DC591053 L193 45.52x52 ECL2 hydrophobic
DC591053 Y204 5.38x39 TM5 hydrophobic
DC591053 R208 5.42x43 TM5 polar (charge-assisted hydrogen bond)
DC591053 F291 7.35x34 TM7 hydrophobic
DC591053 F291 7.35x34 TM7 Van der Waals
DC591053 T295 7.39x38 TM7 polar (hydrogen bond)
DC591053 T295 7.39x38 TM7 Van der Waals
DC591053 H299 7.43x42 TM7 Van der Waals

Ligands

DC591053

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Residue Diagrams

L N G L L G I A G V L G Y A L A V M L R 1 F N L A L A D L G L A L T L P F W A A E 2 A T I L F I S A Y V N L V T A T L V M K 3 A R I A T L A V W A A A A L V T V P T 4 Y S T T I V G L P V M F A L V V R Q L Q Y 5 R I L V A S F F L C W F P N H V V T L W 6 V P N L C S N S H A L C T T V P F V Y 7
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ICL1 R A R A P ICL1ECL1 F H W P F ECL1ICL2 A A G P G T H L ICL2ECL2 V E G E V C G V R L C L L R F P S R ECL2ICL3 Q R ICL3ECL3 V P W N S ECL3N-term M P T L N T S A S P P T F F W A N A S G G S V L S A D D A P M P V K N-termC-term L R L R L W P Q G G G W V Q Q V A L K Q V G R R W V A S N P R E S R P S T L L T N L D R G T P G C-term F L A L R L M V A L A Y G L V G A I G L L G N L A V L W V L S N C G P P S D T F V F N L A L A D L G L A L T L P F W A A E S A L D G G A L C K M V L T A T V L N V Y A S I F L I T A L S V A R Y W V V A M S L F W A R I A T L A V W A A A A L V T V P T A V F G Y W L G A Y Q L Q R V V L A F M V P L G V I T T S Y L L L L A F L Q R R R R Q D S R V V A R S V R I L V A S F F L C W F P N H V V T L W G V L V K F D L T F Y T I Q T Y V F P V T T C L A H S N S C L N P V L Y C L L R R E L A G P R Q A T F R D
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Residue Table


GPCRdb(A)
GPCRdb(A)
RXFP4
TM2
2x60 2.60x60 W97
TM3
3x29 3.29x29 L118
ECL2
45x51 45.51x51 L192
45x52 45.52x52 L193
TM5
5x39 5.38x39 Y204
5x43 5.42x43 R208
TM7
7x34 7.35x34 F291
7x38 7.39x38 T295
7x42 7.43x42 H299