PDB
7YS6
Resolution
3.0 Å
Released
March 29, 2023
Receptor
5-HT6
Class
A
Species
Homo sapiens
Ligand
5-hydroxytryptamine
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
5-hydroxytryptamine D106 3.32x32 TM3 polar (charge-assisted hydrogen bond)
5-hydroxytryptamine V107 3.33x33 TM3 hydrophobic
5-hydroxytryptamine V107 3.33x33 TM3 Van der Waals
5-hydroxytryptamine C110 3.36x36 TM3 polar (hydrogen bond)
5-hydroxytryptamine S111 3.37x37 TM3 Van der Waals
5-hydroxytryptamine L182 45.52x52 ECL2 Van der Waals
5-hydroxytryptamine A192 5.42x43 TM5 hydrophobic
5-hydroxytryptamine A192 5.42x43 TM5 Van der Waals
5-hydroxytryptamine T196 5.46x461 TM5 Van der Waals
5-hydroxytryptamine F284 6.51x51 TM6 Van der Waals
5-hydroxytryptamine F285 6.52x52 TM6 aromatic (edge-to-face)
5-hydroxytryptamine F285 6.52x52 TM6 Van der Waals
5-hydroxytryptamine N288 6.55x55 TM6 polar (hydrogen bond)
5-hydroxytryptamine N288 6.55x55 TM6 Van der Waals

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ICL1 P A L R ICL1ECL1 R W V L ECL1ICL2 P L R Y K L R M ICL2ECL2 W H E L G H A R P P V P G Q C R L L A ECL2ICL3 T G M A S Q A S E T L Q V P R T P R P G V E S A D S R R L A ICL3ECL3 D C I ECL3N-term M V P E P G P T A N S T P A W G A G P P S A P G G N-termC-term P R C P R E R Q A S L A S P S L R T S H S G P R P G L S L Q Q V L P L P L P P D S D S D S D A G S G G S S G L R L T A Q L L L P G E A T Q D P P L P T R A A A A V N F F N I D P A E P E L R P H P L G I P T N C-term S G W V A A A L C V V I A L T A A A N S L L I A L I C T Q N T S N F F L V S L F T S D L M V G L V V M P P A M L N A L Y G A R G L C L L W T A F D V M C C S A S I L N L C L I S L D R Y L L I L S T P L R A L A L V L G A W S L A A L A S F L P L L L G S L P F V L V A S G L T F F L P S G A I C F T Y C R I L L A A R K Q A V Q V A S L T T K H S R K A L K A S L T L G I L L G M F F V T W L P F F V A N I V Q A V C S P G L F D V L T W L G Y C N S T M N P I I Y P L F M R D L G R F K R A F L P C
Helix box plot — Download: PNG | SVG S N A A A T L A I V V C L A A A V W G S 1 V S L F T S D L M V G V L V M P P A M L N 2 L C L N L I S A S C C M V D F A T W L L 3 A L A L V L G A W S L A A L A S F L P L 4 Y T F C I A G S P L F F T L G S A V L V F 5 G I L L G M F F V T W L P F F V A N I V 6 I P N M T S N C Y G L W T L V D F L G 7

GPCRdb(A)
GPCRdb(A)
5-HT6 receptor
TM3
3x32 3.32x32 D106
3x33 3.33x33 V107
3x36 3.36x36 C110
3x37 3.37x37 S111
ECL2
45x52 45.52x52 L182
TM5
5x43 5.42x43 A192
5x461 5.46x461 T196
TM6
6x51 6.51x51 F284
6x52 6.52x52 F285
6x55 6.55x55 N288