PDB
8IYX
Resolution
3.3 Å
Released
March 20, 2024
Receptor
GPR34
Class
A
Species
Homo sapiens
Ligand
YL-365
Function
Antagonist
Reference
10.1073/PNAS.2308435120

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Ligand Amino Acid Generic Number Segment Interaction Type
YL-365 Y135 3.33x33 TM3 hydrophobic
YL-365 Y139 3.37x37 TM3 hydrophobic
YL-365 I143 3.41x41 TM3 hydrophobic
YL-365 F147 3.45x45 TM3 hydrophobic
YL-365 L181 4.52x52 TM4 hydrophobic
YL-365 A182 4.53x53 TM4 hydrophobic
YL-365 G185 4.56x56 TM4 polar (hydrogen bond with backbone)
YL-365 G185 4.56x56 TM4 Van der Waals
YL-365 M189 4.60x60 TM4 hydrophobic
YL-365 M189 4.60x60 TM4 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R K R ICL1ECL1 N K W T L ECL1ICL2 I Q Q R K A I T T ICL2ECL2 G H N S T M C F H Y R D K H N A ECL2ICL3 R R S K F P N ICL3ECL3 Q L N V S ECL3N-term M R S H T I T M T T T S V S S W P Y S S H R M R F I T N H S D Q P P Q N F S A T P N V T T C P M D E K N-termC-term G E P S R S E S T S E F K P G Y S L H D T S V A V K I Q S S S K S T C-term L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N R S K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N M C Q R F Q I R K I L L F R
Helix box plot — Download: PNG | SVG I N G V L G V I F I V S Y S T T L V T S 1 L N V A I A D L L L I F C L P F R I M Y 2 F G L L I I S I Y M N M Y F L T G V V K 3 S I Y V C C I V W M L A L G G F L T M I 4 Y S L I I L L F I L W F M V V L I F N F 5 S F I V L I I F I T C F V P Y H A F R F I 6 V P D L C S N F S S L V L M I E N T K 7

GPCRdb(A)
GPCRdb(A)
GPR34
TM3
3x33 3.33x33 Y135
3x37 3.37x37 Y139
3x41 3.41x41 I143
3x45 3.45x45 F147
TM4
4x52 4.52x52 L181
4x53 4.53x53 A182
4x56 4.56x56 G185
4x60 4.60x60 M189