JMV431


SMILES None
InChIKey DQDBCHHEIKQPJD-ODKJCKIQSA-N
Sequence RRPYIL

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 4GRV 6UP7 6YVR 6Z4V 8JPF 8JPB 8JPC
Ligand site mutations NTS1

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NTS1 NTR1 Human Neurotensin A pKi 5.3 5.3 5.3 Guide to Pharmacology
NTS1 NTR1 Human Neurotensin A pKi 8.89 9.42 9.89 ChEMBL
NTS2 NTR2 Human Neurotensin A pKi 8.18 8.88 9.26 ChEMBL
NTS2 NTR2 Human Neurotensin A pKd 7.0 7.0 7.0 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NTS1 NTR1 Human Neurotensin A pEC50 8.73 9.3 10.38 ChEMBL
NTS1 NTR1 Human Neurotensin A pIC50 9.09 9.19 9.39 ChEMBL
NTS2 NTR2 Human Neurotensin A pIC50 8.12 8.12 8.12 ChEMBL
NTS1 NTR1 Rat Neurotensin A pEC50 8.9 8.9 8.9 ChEMBL