PDB
8RWH
Resolution
2.5 Å
Released
Jan. 8, 2025
Receptor
A2A
Class
A
Species
Homo sapiens
Ligand
StilSwitch2
Function
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
StilSwitch2 F168 45.52x52 ECL2 aromatic (face-to-edge)
StilSwitch2 M177 5.38x40 TM5 hydrophobic
StilSwitch2 W246 6.48x48 TM6 hydrophobic
StilSwitch2 L249 6.51x51 TM6 hydrophobic
StilSwitch2 N253 6.55x55 TM6 Van der Waals
StilSwitch2 N253 6.55x55 TM6 polar (hydrogen bond)
StilSwitch2 H264 ECL3 Van der Waals
StilSwitch2 L267 7.32x31 TM7 hydrophobic
StilSwitch2 L267 7.32x31 TM7 Van der Waals
StilSwitch2 M270 7.35x34 TM7 hydrophobic
StilSwitch2 M270 7.35x34 TM7 Van der Waals
StilSwitch2 I274 7.39x38 TM7 Van der Waals
StilSwitch2 I274 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
Helix box plot — Download: PNG | SVG V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7

GPCRdb(A)
GPCRdb(A)
A2A receptor
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x31 7.32x31 L267
7x34 7.35x34 M270
7x38 7.39x38 I274