PDB
8W8W
Resolution
2.9 Å
Released
March 19, 2025
Receptor
MC3
Class
A
Species
Homo sapiens
Ligand
Alpha-MSH
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Alpha-MSH F45 1.39x39 TM1 hydrophobic
Alpha-MSH E94 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Alpha-MSH T95 2.61x61 TM2 Van der Waals
Alpha-MSH M97 2.63x63 TM2 Van der Waals
Alpha-MSH M97 2.63x63 TM2 hydrophobic
Alpha-MSH I98 2.64x64 TM2 Van der Waals
Alpha-MSH I98 2.64x64 TM2 hydrophobic
Alpha-MSH D110 ECL1 polar (charge-assisted hydrogen bond)
Alpha-MSH I113 3.21x21 TM3 Van der Waals
Alpha-MSH I113 3.21x21 TM3 hydrophobic
Alpha-MSH Q114 3.22x22 TM3 Van der Waals
Alpha-MSH D117 3.25x25 TM3 polar (charge-assisted hydrogen bond)
Alpha-MSH N118 3.26x26 TM3 polar (hydrogen bond)
Alpha-MSH N118 3.26x26 TM3 Van der Waals
Alpha-MSH D121 3.29x29 TM3 polar (charge-assisted hydrogen bond)
Alpha-MSH I124 3.32x32 TM3 Van der Waals
Alpha-MSH I124 3.32x32 TM3 hydrophobic
Alpha-MSH C125 3.33x33 TM3 Van der Waals
Alpha-MSH I180 4.61x61 TM4 hydrophobic
Alpha-MSH I180 4.61x61 TM4 Van der Waals
Alpha-MSH S183 4.64x64 TM4 polar (hydrogen bond)
Alpha-MSH S183 4.64x64 TM4 Van der Waals
Alpha-MSH I189 5.40x40 TM5 Van der Waals
Alpha-MSH I189 5.40x40 TM5 hydrophobic
Alpha-MSH L192 5.43x43 TM5 hydrophobic
Alpha-MSH L192 5.43x43 TM5 Van der Waals
Alpha-MSH F258 6.51x51 TM6 Van der Waals
Alpha-MSH F258 6.51x51 TM6 hydrophobic
Alpha-MSH H261 6.54x54 TM6 polar (hydrogen bond)
Alpha-MSH H261 6.54x54 TM6 Van der Waals
Alpha-MSH L262 6.55x55 TM6 Van der Waals
Alpha-MSH L262 6.55x55 TM6 hydrophobic
Alpha-MSH I265 6.58x58 TM6 hydrophobic
Alpha-MSH I265 6.58x58 TM6 Van der Waals
Alpha-MSH P269 ECL3 Van der Waals
Alpha-MSH F281 7.35x34 TM7 hydrophobic
Alpha-MSH F281 7.35x34 TM7 Van der Waals
Alpha-MSH N282 7.36x35 TM7 polar (hydrogen bond)
Alpha-MSH N282 7.36x35 TM7 Van der Waals
Alpha-MSH L285 7.39x38 TM7 hydrophobic
Alpha-MSH L285 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 G N L H ICL1ECL1 D Y L T F ECL1ICL2 A L R Y H S I M ICL2ECL2 E ECL2ICL3 A L P P A D G V A P Q ICL3ECL3 P T N P Y C I C Y T A ECL3N-term M N A S C C L P S V Q P T L P N G S E H L Q A P F F S N Q S S S A F C E Q V F I N-termC-term N G M N L G C-term K P E V F L S L G I V S L L E N I L V I L A V V R N S P M Y F F L C S L A V A D M L V S V S N A L E T I M I A I V H S E D Q F I Q H M D N I F D S M I C I S L V A S I C N L L A I A V D R Y V T I F Y T V R K A L T L I V A I W V C C G V C G V V F I V Y S S K M V I V C L I T M F F A M M L L M G T L Y V H M F L F A R L H V K R I A Q H S C M K G A V T I T I L L G V F I F C W A P F F L H L V L I I T C H F N T Y L V L I M C N S V I D P L I Y A F R S L E F R E C L R N T I L C G
Helix box plot — Download: PNG | SVG I N E L L S V I G L S L F V E P K 1 C S L A V A D M L V S V S N A L E T I M 2 A L L N C I S A V L S I C I M S D F I N 3 A L T L I V A I W V C C G V C G V V F I 4 Y L T G M L L M M A F F M T I L C V I V 5 T I L L G V F I F C W A P F F L H L V L 6 L P D I V S N C M I L V L Y T N F H 7

GPCRdb(A)
GPCRdb(A)
MC3 receptor
TM1
1x39 1.39x39 F45
TM2
2x60 2.60x60 E94
2x61 2.61x61 T95
2x63 2.63x63 M97
2x64 2.64x64 I98
TM3
3x21 3.21x21 I113
3x22 3.22x22 Q114
3x25 3.25x25 D117
3x26 3.26x26 N118
3x29 3.29x29 D121
3x32 3.32x32 I124
3x33 3.33x33 C125
TM4
4x61 4.61x61 I180
4x64 4.64x64 S183
TM5
5x40 5.40x40 I189
5x43 5.43x43 L192
TM6
6x51 6.51x51 F258
6x54 6.54x54 H261
6x55 6.55x55 L262
6x58 6.58x58 I265
TM7
7x34 7.35x34 F281
7x35 7.36x35 N282
7x38 7.39x38 L285