PDB
8W8X
Resolution
2.9 Å
Released
March 19, 2025
Receptor
MC3
Class
A
Species
Homo sapiens
Ligands
Beta-MSH
Calcium
Function
Agonist
PAM
Reference
—
Beta-MSH Calcium

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Ligand Amino Acid Generic Number Segment Interaction Type
Beta-MSH F45 1.39x39 TM1 hydrophobic
Calcium E94 2.60x60 TM2 polar (charge-charge)
Beta-MSH E94 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Beta-MSH T95 2.61x61 TM2 Van der Waals
Beta-MSH I98 2.64x64 TM2 Van der Waals
Beta-MSH I98 2.64x64 TM2 hydrophobic
Beta-MSH I113 3.21x21 TM3 hydrophobic
Beta-MSH I113 3.21x21 TM3 Van der Waals
Beta-MSH Q114 3.22x22 TM3 Van der Waals
Beta-MSH D117 3.25x25 TM3 polar (charge-assisted hydrogen bond)
Beta-MSH N118 3.26x26 TM3 polar (hydrogen bond)
Calcium D121 3.29x29 TM3 polar (charge-charge)
Beta-MSH D121 3.29x29 TM3 polar (charge-assisted hydrogen bond)
Beta-MSH I124 3.32x32 TM3 hydrophobic
Beta-MSH I124 3.32x32 TM3 Van der Waals
Beta-MSH C125 3.33x33 TM3 hydrophobic
Beta-MSH C125 3.33x33 TM3 Van der Waals
Beta-MSH F179 4.60x60 TM4 Van der Waals
Beta-MSH I180 4.61x61 TM4 Van der Waals
Beta-MSH I180 4.61x61 TM4 hydrophobic
Beta-MSH E184 ECL2 polar (charge-assisted hydrogen bond)
Beta-MSH E184 ECL2 polar (hydrogen bond with backbone)
Beta-MSH I189 5.40x40 TM5 Van der Waals
Beta-MSH I189 5.40x40 TM5 hydrophobic
Beta-MSH L192 5.43x43 TM5 hydrophobic
Beta-MSH L192 5.43x43 TM5 Van der Waals
Beta-MSH H261 6.54x54 TM6 Van der Waals
Beta-MSH L262 6.55x55 TM6 hydrophobic
Beta-MSH L262 6.55x55 TM6 Van der Waals
Beta-MSH I265 6.58x58 TM6 hydrophobic
Beta-MSH I265 6.58x58 TM6 Van der Waals
Beta-MSH F281 7.35x34 TM7 hydrophobic
Beta-MSH F281 7.35x34 TM7 Van der Waals
Beta-MSH N282 7.36x35 TM7 Van der Waals
Beta-MSH L285 7.39x38 TM7 Van der Waals
Beta-MSH L285 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 G N L H ICL1ECL1 D Y L T F ECL1ICL2 A L R Y H S I M ICL2ECL2 E ECL2ICL3 A L P P A D G V A P Q ICL3ECL3 P T N P Y C I C Y T A ECL3N-term M N A S C C L P S V Q P T L P N G S E H L Q A P F F S N Q S S S A F C E Q V F I N-termC-term N G M N L G C-term K P E V F L S L G I V S L L E N I L V I L A V V R N S P M Y F F L C S L A V A D M L V S V S N A L E T I M I A I V H S E D Q F I Q H M D N I F D S M I C I S L V A S I C N L L A I A V D R Y V T I F Y T V R K A L T L I V A I W V C C G V C G V V F I V Y S S K M V I V C L I T M F F A M M L L M G T L Y V H M F L F A R L H V K R I A Q H S C M K G A V T I T I L L G V F I F C W A P F F L H L V L I I T C H F N T Y L V L I M C N S V I D P L I Y A F R S L E F R E C L R N T I L C G
Helix box plot — Download: PNG | SVG I N E L L S V I G L S L F V E P K 1 C S L A V A D M L V S V S N A L E T I M 2 A L L N C I S A V L S I C I M S D F I N 3 A L T L I V A I W V C C G V C G V V F I 4 Y L T G M L L M M A F F M T I L C V I V 5 T I L L G V F I F C W A P F F L H L V L 6 L P D I V S N C M I L V L Y T N F H 7

GPCRdb(A)
GPCRdb(A)
MC3 receptor
TM1
1x39 1.39x39 F45
TM2
2x60 2.60x60 E94
2x61 2.61x61 T95
2x64 2.64x64 I98
TM3
3x21 3.21x21 I113
3x22 3.22x22 Q114
3x25 3.25x25 D117
3x26 3.26x26 N118
3x29 3.29x29 D121
3x32 3.32x32 I124
3x33 3.33x33 C125
TM4
4x60 4.60x60 F179
4x61 4.61x61 I180
TM5
5x40 5.40x40 I189
5x43 5.43x43 L192
TM6
6x54 6.54x54 H261
6x55 6.55x55 L262
6x58 6.58x58 I265
TM7
7x34 7.35x34 F281
7x35 7.36x35 N282
7x38 7.39x38 L285