PDB
8WST
Resolution
2.4 Å
Released
June 19, 2024
Receptor
MCH2
Class
A
Species
Homo sapiens
Ligand
melanin-concentrating hormone (Human)
Function
Agonist
Reference
10.1038/S41421-024-00679-8

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Ligand Amino Acid Generic Number Segment Interaction Type
melanin-concentrating hormone (Human) H82 2.53x53 TM2 polar (hydrogen bond)
melanin-concentrating hormone (Human) Q92 2.63x63 TM2 Van der Waals
melanin-concentrating hormone (Human) W93 2.64x64 TM2 Van der Waals
melanin-concentrating hormone (Human) W93 2.64x64 TM2 polar (hydrogen bond)
melanin-concentrating hormone (Human) G96 2.67x67 TM2 polar (hydrogen bond with backbone)
melanin-concentrating hormone (Human) G96 2.67x67 TM2 Van der Waals
melanin-concentrating hormone (Human) G97 ECL1 Van der Waals
melanin-concentrating hormone (Human) D113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
melanin-concentrating hormone (Human) Q117 3.36x36 TM3 polar (hydrogen bond)
melanin-concentrating hormone (Human) F177 ECL2 Van der Waals
melanin-concentrating hormone (Human) F177 ECL2 hydrophobic
melanin-concentrating hormone (Human) S183 ECL2 Van der Waals
melanin-concentrating hormone (Human) C184 45.50x50 ECL2 Van der Waals
melanin-concentrating hormone (Human) C184 45.50x50 ECL2 hydrophobic
melanin-concentrating hormone (Human) A185 45.51x51 ECL2 hydrophobic
melanin-concentrating hormone (Human) A185 45.51x51 ECL2 Van der Waals
melanin-concentrating hormone (Human) F186 45.52x52 ECL2 Van der Waals
melanin-concentrating hormone (Human) F186 45.52x52 ECL2 polar (hydrogen bond with backbone)
melanin-concentrating hormone (Human) L188 ECL2 hydrophobic
melanin-concentrating hormone (Human) L188 ECL2 Van der Waals
melanin-concentrating hormone (Human) T189 ECL2 Van der Waals
melanin-concentrating hormone (Human) P191 5.32x33 TM5 hydrophobic
melanin-concentrating hormone (Human) P191 5.32x33 TM5 Van der Waals
melanin-concentrating hormone (Human) V194 5.35x36 TM5 Van der Waals
melanin-concentrating hormone (Human) V194 5.35x36 TM5 hydrophobic
melanin-concentrating hormone (Human) Y197 5.38x39 TM5 hydrophobic
melanin-concentrating hormone (Human) Y267 6.51x51 TM6 Van der Waals
melanin-concentrating hormone (Human) Q271 6.55x55 TM6 polar (hydrogen bond)
melanin-concentrating hormone (Human) N274 6.58x58 TM6 polar (hydrogen bond)
melanin-concentrating hormone (Human) N274 6.58x58 TM6 Van der Waals
melanin-concentrating hormone (Human) Q279 ECL3 Van der Waals
melanin-concentrating hormone (Human) P280 ECL3 Van der Waals
melanin-concentrating hormone (Human) P280 ECL3 hydrophobic
melanin-concentrating hormone (Human) F284 7.31x30 TM7 Van der Waals
melanin-concentrating hormone (Human) Y285 7.32x31 TM7 Van der Waals
melanin-concentrating hormone (Human) Y285 7.32x31 TM7 polar (hydrogen bond)
melanin-concentrating hormone (Human) Y288 7.35x34 TM7 polar (hydrogen bond)
melanin-concentrating hormone (Human) I292 7.39x38 TM7 hydrophobic
melanin-concentrating hormone (Human) I292 7.39x38 TM7 Van der Waals
melanin-concentrating hormone (Human) S295 7.42x41 TM7 polar (hydrogen bond)
melanin-concentrating hormone (Human) Y296 7.43x42 TM7 polar (hydrogen bond)

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ICL1 R K K ICL1ECL1 G E W V F ECL1ICL2 P F R L T R W R ICL2ECL2 K V I K F K D G V E S C A F D L T ECL2ICL3 D A R C C ICL3ECL3 E Q P ECL3N-term M N P F H A S C W N T S A E L L N K S W N K E F A Y Q T A S N-termC-term R A T E K E I N N M G N T L K S H F C-term V V D T V I L P S M I G I I C S T G L V G N I L I V F T I I R S T V P D I Y I C N L A V A D L V H I V G M P F L I H Q W A R G G G P L C T I I T S L D T C N Q F A C S A I M T V M S V D R Y F A L V Q T R Y K T I R I N L G L W A A S F I L A L P V W V Y S S P D D V L W Y T L Y L T I T T F F F P L P L I L V C Y I L I L C Y T W E M Y Q Q N K N P S V P K Q R V M K L T K M V L V L V V V F I L S A A P Y H V I Q L V N L Q M T L A F Y V G Y Y L S I C L S Y A S S S I N P F L Y I L L S G N L P Q F Q K R I Q R
Helix box plot — Download: PNG | SVG I N G V L G T S C I I G I M S P L I V T 1 C N L A V A D L V H I V G M P F L I H Q 2 V T M I A S C A F Q N C T D L S T I I T 3 T I R I N L G L W A A S F I L A L P V 4 Y C V L I L P L P F F F T T I T L Y L T Y 5 L V L V V V F I L S A A P Y H V I Q L V 6 F P N I S S S A Y S L C I S L Y Y G V 7

GPCRdb(A)
GPCRdb(A)
MCH2 receptor
TM2
2x53 2.53x53 H82
2x63 2.63x63 Q92
2x64 2.64x64 W93
2x67 2.67x67 G96
TM3
3x32 3.32x32 D113
3x36 3.36x36 Q117
ECL2
45x50 45.50x50 C184
45x51 45.51x51 A185
45x52 45.52x52 F186
TM5
5x33 5.32x33 P191
5x36 5.35x36 V194
5x39 5.38x39 Y197
TM6
6x51 6.51x51 Y267
6x55 6.55x55 Q271
6x58 6.58x58 N274
TM7
7x30 7.31x30 F284
7x31 7.32x31 Y285
7x34 7.35x34 Y288
7x38 7.39x38 I292
7x41 7.42x41 S295
7x42 7.43x42 Y296