PDB
8XWM
Resolution
3.7 Å
Released
Jan. 15, 2025
Receptor
CXCR2
Class
A
Species
Homo sapiens
Ligand
CXCL6
Function
Agonist
Reference
10.1016/J.MOLCEL.2025.01.024

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Ligand Amino Acid Generic Number Segment Interaction Type
CXCL6 D35 N-term polar (charge-assisted hydrogen bond)
CXCL6 A36 N-term hydrophobic
CXCL6 A36 N-term Van der Waals
CXCL6 A37 N-term Van der Waals
CXCL6 P38 N-term hydrophobic
CXCL6 P38 N-term Van der Waals
CXCL6 P41 N-term hydrophobic
CXCL6 V187 ECL2 Van der Waals
CXCL6 V187 ECL2 hydrophobic
CXCL6 S189 ECL2 Van der Waals
CXCL6 S189 ECL2 polar (hydrogen bond)
CXCL6 N191 ECL2 Van der Waals
CXCL6 V192 ECL2 hydrophobic
CXCL6 V192 ECL2 Van der Waals
CXCL6 S193 ECL2 polar (hydrogen bond)
CXCL6 S193 ECL2 polar (hydrogen bond with backbone)
CXCL6 S193 ECL2 polar (hydrogen bond)
CXCL6 Y197 45.51x51 ECL2 hydrophobic
CXCL6 Y197 45.51x51 ECL2 Van der Waals
CXCL6 G201 ECL2 Van der Waals
CXCL6 N202 ECL2 polar (hydrogen bond)
CXCL6 N202 ECL2 polar (hydrogen bond with backbone)
CXCL6 N202 ECL2 Van der Waals
CXCL6 N203 5.30x31 TM5 polar (hydrogen bond)
CXCL6 N203 5.30x31 TM5 Van der Waals
CXCL6 R208 5.35x36 TM5 polar (charge-assisted hydrogen bond)
CXCL6 R212 5.39x40 TM5 polar (charge-assisted hydrogen bond)
CXCL6 D274 6.58x58 TM6 Van der Waals
CXCL6 M277 6.61x61 TM6 Van der Waals
CXCL6 R278 6.62x62 TM6 polar (charge-assisted hydrogen bond)
CXCL6 E284 ECL3 Van der Waals
CXCL6 R289 7.28x27 TM7 polar (charge-assisted hydrogen bond)
CXCL6 D293 7.32x31 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R V G R ICL1ECL1 G W I F ECL1ICL2 A T R T L T Q K R Y ICL2ECL2 R T V Y S S N V S P A C Y E D M G N ECL2ICL3 H M G ICL3ECL3 V I Q E ECL3N-term M E D F N M E S D S F E D F W K G E D L S N Y S Y S S T L P P F L L D A A P C E P E S L N-termC-term G L I S K D S L P K D S R P S F V G S S S G H T S T T L C-term E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H L V K F I C L S I W G L S L L L A L P V L L F R N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K L L K H F R H G I L A I
Helix box plot — Download: PNG | SVG S N G L L S L L F V L A Y I I V V F Y K 1 L N L A L A D L L F A L T L P I W A A S 2 C A L L L I G S Y F N V E K L L S V V K 3 V K F I C L S I W G L S L L L A L P V 4 Y C F L M I L L P V I F G F S Q P L I R L 5 F A V V L I F L L C W L P Y N L V L L A 6 L P N L C S H L I G L I E T A D L A R 7

GPCRdb(A)
GPCRdb(A)
CXCR2
ECL2
45x51 45.51x51 Y197
TM5
5x31 5.30x31 N203
5x36 5.35x36 R208
5x40 5.39x40 R212
TM6
6x58 6.58x58 D274
6x61 6.61x61 M277
6x62 6.62x62 R278
TM7
7x27 7.28x27 R289
7x31 7.32x31 D293