Structure information

apelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XZG

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2024.02.004

PUBLICATION DATE

March 27, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
[Pyr<sup>1</sup>]apelin-13 W85 2.60x60 TM2 hydrophobic
[Pyr<sup>1</sup>]apelin-13 Y88 2.63x63 TM2 Van der Waals
[Pyr<sup>1</sup>]apelin-13 Y88 2.63x63 TM2 polar (hydrogen bond)
[Pyr<sup>1</sup>]apelin-13 Y93 ECL1 Van der Waals
[Pyr<sup>1</sup>]apelin-13 S106 3.29x29 TM3 Van der Waals
[Pyr<sup>1</sup>]apelin-13 I109 3.32x32 TM3 hydrophobic
[Pyr<sup>1</sup>]apelin-13 I109 3.32x32 TM3 Van der Waals
[Pyr<sup>1</sup>]apelin-13 F110 3.33x33 TM3 Van der Waals
[Pyr<sup>1</sup>]apelin-13 F110 3.33x33 TM3 hydrophobic
[Pyr<sup>1</sup>]apelin-13 P163 4.59x60 TM4 hydrophobic
[Pyr<sup>1</sup>]apelin-13 P163 4.59x60 TM4 Van der Waals
[Pyr<sup>1</sup>]apelin-13 V164 4.60x61 TM4 Van der Waals
[Pyr<sup>1</sup>]apelin-13 R168 ECL2 polar (charge-assisted hydrogen bond)
[Pyr<sup>1</sup>]apelin-13 C181 45.50x50 ECL2 Van der Waals
[Pyr<sup>1</sup>]apelin-13 Y182 45.51x51 ECL2 hydrophobic
[Pyr<sup>1</sup>]apelin-13 Y182 45.51x51 ECL2 Van der Waals
[Pyr<sup>1</sup>]apelin-13 M183 45.52x52 ECL2 Van der Waals
[Pyr<sup>1</sup>]apelin-13 M183 45.52x52 ECL2 hydrophobic
[Pyr<sup>1</sup>]apelin-13 Y185 ECL2 Van der Waals
[Pyr<sup>1</sup>]apelin-13 E198 5.35x36 TM5 polar (charge-assisted hydrogen bond)
[Pyr<sup>1</sup>]apelin-13 L201 5.38x39 TM5 hydrophobic
[Pyr<sup>1</sup>]apelin-13 L201 5.38x39 TM5 Van der Waals
[Pyr<sup>1</sup>]apelin-13 S205 5.42x43 TM5 Van der Waals
[Pyr<sup>1</sup>]apelin-13 Y264 6.51x51 TM6 polar (hydrogen bond)
[Pyr<sup>1</sup>]apelin-13 Y264 6.51x51 TM6 polar (hydrogen bond)
[Pyr<sup>1</sup>]apelin-13 K268 6.55x55 TM6 polar (charge-assisted hydrogen bond)
[Pyr<sup>1</sup>]apelin-13 Y271 6.58x58 TM6 polar (hydrogen bond)
[Pyr<sup>1</sup>]apelin-13 Y271 6.58x58 TM6 Van der Waals
[Pyr<sup>1</sup>]apelin-13 S275 6.62x62 TM6 Van der Waals
[Pyr<sup>1</sup>]apelin-13 D284 7.28x27 TM7 polar (charge-assisted hydrogen bond)
[Pyr<sup>1</sup>]apelin-13 L285 7.29x28 TM7 Van der Waals
[Pyr<sup>1</sup>]apelin-13 L285 7.29x28 TM7 hydrophobic
[Pyr<sup>1</sup>]apelin-13 F291 7.35x34 TM7 hydrophobic
[Pyr<sup>1</sup>]apelin-13 F291 7.35x34 TM7 Van der Waals
[Pyr<sup>1</sup>]apelin-13 Y299 7.43x42 TM7 Van der Waals
[Pyr<sup>1</sup>]apelin-13 Y299 7.43x42 TM7 hydrophobic

Ligands

[Pyr<sup>1</sup>]apelin-13

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Residue Diagrams

G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7
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ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
2x63 2.63x63 Y88
TM3
3x29 3.29x29 S106
3x32 3.32x32 I109
3x33 3.33x33 F110
TM4
4x60 4.59x60 P163
4x61 4.60x61 V164
ECL2
45x50 45.50x50 C181
45x51 45.51x51 Y182
45x52 45.52x52 M183
TM5
5x36 5.35x36 E198
5x39 5.38x39 L201
5x43 5.42x43 S205
TM6
6x51 6.51x51 Y264
6x55 6.55x55 K268
6x58 6.58x58 Y271
6x62 6.62x62 S275
TM7
7x27 7.28x27 D284
7x28 7.29x28 L285
7x34 7.35x34 F291
7x42 7.43x42 Y299