Structure information

GPR119

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ZRK

SPECIES

Homo sapiens

RESOLUTION

2.820

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

June 19, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
GSK-1292263 L61 2.60x60 TM2 polar (hydrogen bond)
GSK-1292263 Q65 ECL1 Van der Waals
GSK-1292263 M82 3.29x29 TM3 polar (hydrogen bond)
GSK-1292263 V85 3.32x32 TM3 polar (hydrogen bond)
GSK-1292263 T86 3.33x33 TM3 Van der Waals
GSK-1292263 T86 3.33x33 TM3 polar (hydrogen bond with backbone)
GSK-1292263 A89 3.36x36 TM3 Van der Waals
GSK-1292263 A90 3.37x37 TM3 polar (hydrogen bond)
GSK-1292263 A90 3.37x37 TM3 polar (hydrogen bond with backbone)
GSK-1292263 V93 3.40x40 TM3 polar (hydrogen bond)
GSK-1292263 L94 3.41x41 TM3 Van der Waals
GSK-1292263 I136 4.56x56 TM4 Van der Waals
GSK-1292263 S156 45.51x51 ECL2 polar (hydrogen bond)
GSK-1292263 F157 45.52x52 ECL2 polar (hydrogen bond)
GSK-1292263 F157 45.52x52 ECL2 polar (hydrogen bond with backbone)
GSK-1292263 L169 5.43x44 TM5 polar (hydrogen bond)
GSK-1292263 G173 5.47x47 TM5 Van der Waals
GSK-1292263 F174 5.48x48 TM5 Van der Waals
GSK-1292263 F174 5.48x48 TM5 polar (hydrogen bond with backbone)
GSK-1292263 A177 5.51x51 TM5 Van der Waals
GSK-1292263 W238 6.48x48 TM6 polar (hydrogen bond)
GSK-1292263 F241 6.51x51 TM6 hydrophobic
GSK-1292263 F241 6.51x51 TM6 Van der Waals
GSK-1292263 L242 6.52x52 TM6 Van der Waals
GSK-1292263 E261 7.35x34 TM7 polar (hydrogen bond with backbone)
GSK-1292263 E261 7.35x34 TM7 Van der Waals
GSK-1292263 W265 7.39x38 TM7 polar (hydrogen bond)
GSK-1292263 W265 7.39x38 TM7 polar (hydrogen bond)
GSK-1292263 W265 7.39x38 TM7 aromatic (face-to-face)

Ligands

GSK-1292263

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Residue Diagrams

T N T A I I L S A L V A L I V G F S F S 1 L N L A V A D T L I G V A I S G L L T D 2 L M V T L V S A A A S S T V F A M R L S 3 A G A C I A G L W L V S Y L I G F L P L 4 F F V F L L M A P F F G V C S L T L V F H 5 S V L I G S F A L S W T P F L I T G I V 6 L P N L L S N G V G L L W L Y R E L V 7
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ICL1 I H K N D ICL1ECL1 S P S ECL1ICL2 P F R Y L K I M ICL2ECL2 P M F Q Q T A Y K G Q C S F F A V ECL2ICL3 A M A G G Y ICL3ECL3 Q E C H L ECL3C-term G V K K V L T S F L L F L S A R N C G P E R P R E S S C H I V T I S S S E F D G C-term M E S S F S F G V I L A V L A S L I I A T N T L V A V A V L L L G V S L C F T L N L A V A D T L I G V A I S G L L T D Q L S R P T Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q S G F V A G A C I A G L W L V S Y L I G F L P L G I F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G R S P R T P S D F K A L R T V S V L I G S F A L S W T P F L I T G I V Q V A C Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E L Y H V R L Q M A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR119
TM2
2x60 2.60x60 L61
TM3
3x29 3.29x29 M82
3x32 3.32x32 V85
3x33 3.33x33 T86
3x36 3.36x36 A89
3x37 3.37x37 A90
3x40 3.40x40 V93
3x41 3.41x41 L94
TM4
4x56 4.56x56 I136
ECL2
45x51 45.51x51 S156
45x52 45.52x52 F157
TM5
5x44 5.43x44 L169
5x47 5.47x47 G173
5x48 5.48x48 F174
5x51 5.51x51 A177
TM6
6x48 6.48x48 W238
6x51 6.51x51 F241
6x52 6.52x52 L242
TM7
7x34 7.35x34 E261
7x38 7.39x38 W265