PDB
9KFJ
Resolution
3.1 Å
Released
Aug. 13, 2025
Receptor
RXFP3
Class
A
Species
Homo sapiens
Ligand
CHEMBL4522365
Function
Agonist
Reference
10.1038/S42003-025-08220-7

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4522365 W138 2.60x60 TM2 hydrophobic
CHEMBL4522365 F146 ECL1 hydrophobic
CHEMBL4522365 C247 45.50x50 ECL2 Van der Waals
CHEMBL4522365 C247 45.50x50 ECL2 polar (hydrogen bond with backbone)
CHEMBL4522365 K271 5.42x43 TM5 polar (charge-assisted hydrogen bond)
CHEMBL4522365 W339 6.48x48 TM6 Van der Waals
CHEMBL4522365 W339 6.48x48 TM6 hydrophobic
CHEMBL4522365 Q367 7.31x30 TM7 Van der Waals
CHEMBL4522365 F371 7.35x34 TM7 hydrophobic
CHEMBL4522365 F371 7.35x34 TM7 Van der Waals
CHEMBL4522365 V375 7.39x38 TM7 hydrophobic
CHEMBL4522365 V375 7.39x38 TM7 Van der Waals
CHEMBL4522365 H379 7.43x42 TM7 Van der Waals

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ICL1 Q G W R ICL1ECL1 D F K W P F ECL1ICL2 A L K S H R T R G H G R G D C C G R S L G D S ICL2ECL2 T T V K V M G E E L C L V R F P D K L L G R D ECL2ICL3 G G R P ICL3ECL3 A V P F ECL3N-term M Q M A D A A T I A T M N K A A G G D K L A E L F S L V P D L L E A A N T S G N A S L Q L P D L W W E L G L E L P D G A P P G H P P G S G G A E S A D T E N-termC-term R I A S P S I T S M R P F T A T T K P E H E D Q G L Q A P A P P H A A A E P D L L Y Y P P G V V V Y S G G R Y D L L P S S S A Y C-term A R V R I L I S V V Y W V V C A L G L A G N L L V L Y L M K S M K S S I N L F V T N L A L T D F Q F V L T L P F W A V E N A L G K A M C K I V S M V T S M N M Y A S V F F L T A M S V T R Y H S V A S C C F S A K A L C V W I W A L A A L A S L P S A I F S R Q F W L G L Y H S Q K V L L G F V L P L G I I I L C Y L L L V R F I A D R R A A G T K G G A A V A T G A S A R R L S K V T K S V T I V V L S F F L C W L P N Q A L T T W S I L I K F N S Q E Y F L C Q V Y A F P V S V C L A H S N S C L N P V L Y C L V R R E L K S F R K A L L W
Helix box plot — Download: PNG | SVG L N G A L G L A C V V W Y V V S I L I R 1 T N L A L T D F Q F V L T L P F W A V E 2 A T L F F V S A Y M N M S T V M S V I K 3 A K A L C V W I W A L A A L A S L P S 4 Y C L I I I G L P L V F G L L V K Q S H Y 5 T I V V L S F F L C W L P N Q A L T T W 6 V P N L C S N S H A L C V S V P F A Y 7

GPCRdb(A)
GPCRdb(A)
RXFP3
TM2
2x60 2.60x60 W138
ECL2
45x50 45.50x50 C247
TM5
5x43 5.42x43 K271
TM6
6x48 6.48x48 W339
TM7
7x30 7.31x30 Q367
7x34 7.35x34 F371
7x38 7.39x38 V375
7x42 7.43x42 H379