PDB
9KFK
Resolution
3.0 Å
Released
Aug. 13, 2025
Receptor
RXFP4
Class
A
Species
Homo sapiens
Ligands
Relaxin-3 (chain B)
Relaxin-3 (chain A)
Function
Agonist
Agonist
Reference
10.1038/S42003-025-08220-7
Relaxin-3 (chain B) Relaxin-3 (chain A)

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Ligand Amino Acid Generic Number Segment Interaction Type
Relaxin-3 (chain B) W97 2.60x60 TM2 hydrophobic
Relaxin-3 (chain B) E100 2.63x63 TM2 polar (charge-assisted hydrogen bond)
Relaxin-3 (chain B) D104 ECL1 polar (charge-assisted hydrogen bond)
Relaxin-3 (chain B) F105 ECL1 hydrophobic
Relaxin-3 (chain B) T121 3.32x32 TM3 Van der Waals
Relaxin-3 (chain B) V122 3.33x33 TM3 Van der Waals
Relaxin-3 (chain B) V122 3.33x33 TM3 hydrophobic
Relaxin-3 (chain B) V125 3.36x36 TM3 Van der Waals
Relaxin-3 (chain B) V125 3.36x36 TM3 hydrophobic
Relaxin-3 (chain A) E184 ECL2 polar (charge-assisted hydrogen bond)
Relaxin-3 (chain A) V185 ECL2 Van der Waals
Relaxin-3 (chain B) C186 ECL2 Van der Waals
Relaxin-3 (chain A) C186 ECL2 Van der Waals
Relaxin-3 (chain B) C186 ECL2 hydrophobic
Relaxin-3 (chain B) V188 ECL2 hydrophobic
Relaxin-3 (chain B) V188 ECL2 Van der Waals
Relaxin-3 (chain B) L190 ECL2 Van der Waals
Relaxin-3 (chain B) L190 ECL2 hydrophobic
Relaxin-3 (chain B) C191 45.50x50 ECL2 Van der Waals
Relaxin-3 (chain B) C191 45.50x50 ECL2 polar (hydrogen bond with backbone)
Relaxin-3 (chain B) L192 45.51x51 ECL2 hydrophobic
Relaxin-3 (chain B) L192 45.51x51 ECL2 Van der Waals
Relaxin-3 (chain A) L192 45.51x51 ECL2 Van der Waals
Relaxin-3 (chain A) L193 45.52x52 ECL2 Van der Waals
Relaxin-3 (chain B) L193 45.52x52 ECL2 Van der Waals
Relaxin-3 (chain A) R194 ECL2 polar (charge-assisted hydrogen bond)
Relaxin-3 (chain A) F195 ECL2 polar (hydrogen bond with backbone)
Relaxin-3 (chain A) F195 ECL2 Van der Waals
Relaxin-3 (chain A) S197 ECL2 Van der Waals
Relaxin-3 (chain B) L201 5.35x36 TM5 Van der Waals
Relaxin-3 (chain B) L201 5.35x36 TM5 hydrophobic
Relaxin-3 (chain B) Q205 5.39x40 TM5 polar (hydrogen bond)
Relaxin-3 (chain B) Q205 5.39x40 TM5 polar (hydrogen bond)
Relaxin-3 (chain B) R208 5.42x43 TM5 polar (charge-assisted hydrogen bond)
Relaxin-3 (chain B) W259 6.48x48 TM6 hydrophobic
Relaxin-3 (chain B) W259 6.48x48 TM6 Van der Waals
Relaxin-3 (chain B) W279 ECL3 Van der Waals
Relaxin-3 (chain B) Q287 7.31x30 TM7 polar (hydrogen bond)
Relaxin-3 (chain B) F291 7.35x34 TM7 hydrophobic
Relaxin-3 (chain B) F291 7.35x34 TM7 Van der Waals
Relaxin-3 (chain B) H299 7.43x42 TM7 Van der Waals
Relaxin-3 (chain B) H299 7.43x42 TM7 aromatic (face-to-edge)

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Snake plot — Download: PNG | SVG
ICL1 R A R A P ICL1ECL1 F H W P F ECL1ICL2 A A G P G T H L ICL2ECL2 V E G E V C G V R L C L L R F P S R ECL2ICL3 Q R ICL3ECL3 V P W N S ECL3N-term M P T L N T S A S P P T F F W A N A S G G S V L S A D D A P M P V K N-termC-term L R L R L W P Q G G G W V Q Q V A L K Q V G R R W V A S N P R E S R P S T L L T N L D R G T P G C-term F L A L R L M V A L A Y G L V G A I G L L G N L A V L W V L S N C G P P S D T F V F N L A L A D L G L A L T L P F W A A E S A L D G G A L C K M V L T A T V L N V Y A S I F L I T A L S V A R Y W V V A M S L F W A R I A T L A V W A A A A L V T V P T A V F G Y W L G A Y Q L Q R V V L A F M V P L G V I T T S Y L L L L A F L Q R R R R Q D S R V V A R S V R I L V A S F F L C W F P N H V V T L W G V L V K F D L T F Y T I Q T Y V F P V T T C L A H S N S C L N P V L Y C L L R R E L A G P R Q A T F R D
Helix box plot — Download: PNG | SVG L N G L L G I A G V L G Y A L A V M L R 1 F N L A L A D L G L A L T L P F W A A E 2 A T I L F I S A Y V N L V T A T L V M K 3 A R I A T L A V W A A A A L V T V P T 4 Y S T T I V G L P V M F A L V V R Q L Q Y 5 R I L V A S F F L C W F P N H V V T L W 6 V P N L C S N S H A L C T T V P F V Y 7

GPCRdb(A)
GPCRdb(A)
RXFP4
TM2
2x60 2.60x60 W97
2x63 2.63x63 E100
TM3
3x32 3.32x32 T121
3x33 3.33x33 V122
3x36 3.36x36 V125
ECL2
45x50 45.50x50 C191
45x51 45.51x51 L192
45x52 45.52x52 L193
TM5
5x36 5.35x36 L201
5x40 5.39x40 Q205
5x43 5.42x43 R208
TM6
6x48 6.48x48 W259
TM7
7x30 7.31x30 Q287
7x34 7.35x34 F291
7x42 7.43x42 H299