PDB
9M4T
Resolution
3.2 Å
Released
July 2, 2025
Receptor
α1A
Class
A
Species
Homo sapiens
Ligand
silodosin
Function
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
silodosin S83 2.61x60 TM2 polar (hydrogen bond with backbone)
silodosin S83 2.61x60 TM2 polar (hydrogen bond)
silodosin F86 2.64x63 TM2 polar (hydrogen bond)
silodosin E87 2.65x64 TM2 polar (charge-assisted hydrogen bond)
silodosin G90 2.68x67 TM2 polar (hydrogen bond)
silodosin W102 3.28x28 TM3 Van der Waals
silodosin W102 3.28x28 TM3 aromatic (edge-to-face)
silodosin D106 3.32x32 TM3 polar (hydrogen bond with backbone)
silodosin D106 3.32x32 TM3 polar (charge-assisted hydrogen bond)
silodosin V107 3.33x33 TM3 polar (hydrogen bond with backbone)
silodosin V107 3.33x33 TM3 Van der Waals
silodosin C110 3.36x36 TM3 polar (hydrogen bond)
silodosin T111 3.37x37 TM3 polar (hydrogen bond)
silodosin Q177 45.51x51 ECL2 Van der Waals
silodosin I178 45.52x52 ECL2 polar (hydrogen bond)
silodosin Y184 5.38x39 TM5 polar (hydrogen bond)
silodosin V185 5.39x40 TM5 polar (hydrogen bond)
silodosin S188 5.42x43 TM5 polar (hydrogen bond)
silodosin A189 5.43x44 TM5 Van der Waals
silodosin S192 5.46x461 TM5 polar (hydrogen bond)
silodosin W285 6.48x48 TM6 hydrophobic
silodosin W285 6.48x48 TM6 Van der Waals
silodosin F288 6.51x51 TM6 aromatic (edge-to-face)
silodosin F288 6.51x51 TM6 polar (hydrogen bond)
silodosin F289 6.52x52 TM6 Van der Waals
silodosin F289 6.52x52 TM6 aromatic (edge-to-face)
silodosin M292 6.55x55 TM6 polar (hydrogen bond)
silodosin F312 7.39x38 TM7 hydrophobic
silodosin F312 7.39x38 TM7 Van der Waals
silodosin W313 7.40x39 TM7 polar (hydrogen bond)
silodosin Y316 7.43x42 TM7 polar (hydrogen bond)

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ICL1 R H L H ICL1ECL1 Y W A F ECL1ICL2 P L R Y P T I V ICL2ECL2 R Q P A P E D E T I C Q I N E ECL2ICL3 K T D K S D S E Q V T L R I H R K N A P A G G S G M A S A K T K T H F S V R ICL3ECL3 P D F K P ECL3N-term M V F L S G N A S D S S N C T Q P P A N-termC-term I Q C L C R K Q S S K H A L G Y T L H P P S Q A V E G Q H K D M V R I P V G S R E T F Y R I S K T D G V C E W K F F S S M P R G S A R I T V S K D Q S S C T T A R V R S K S F L Q V C C C V G P S T P S L D K N H Q V P T I K V H T I S L S E N G E E V C-term P V N I S K A I L L G V I L G G L I L F G V L G N I L V I L S V A C H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y T Q R R G L M A L L C V W A L S L V I S I G P L F G W E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E S R G L K S G L L L K F S R E K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F S E T V F K I V F W L G Y L N S C I N P I I Y P C S S Q E F Q N F K K A V L R
Helix box plot — Download: PNG | SVG I N G L V G F L I L G G L I V G L L I A 1 V N L A V A D L L L T T S V L P F S A I F 2 I C L G M I S A T C C L V D V A A W I N 3 G L M A L L C V W A L S L V I S I G P L 4 Y M V L I I A L P L Y F S G L A S F L V Y 5 G I V V G C F V L C W L P F F L V M P I 6 I P N I C S N L Y G L W F V I K F V T 7

GPCRdb(A)
GPCRdb(A)
α1A-adrenoceptor
TM2
2x60 2.61x60 S83
2x63 2.64x63 F86
2x64 2.65x64 E87
2x67 2.68x67 G90
TM3
3x28 3.28x28 W102
3x32 3.32x32 D106
3x33 3.33x33 V107
3x36 3.36x36 C110
3x37 3.37x37 T111
ECL2
45x51 45.51x51 Q177
45x52 45.52x52 I178
TM5
5x39 5.38x39 Y184
5x40 5.39x40 V185
5x43 5.42x43 S188
5x44 5.43x44 A189
5x461 5.46x461 S192
TM6
6x48 6.48x48 W285
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 M292
TM7
7x38 7.39x38 F312
7x39 7.40x39 W313
7x42 7.43x42 Y316