PDB
9PXU
Resolution
3.4 Å
Released
Nov. 12, 2025
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
naloxone
Function
Agonist (partial)
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
naloxone Y150 3.33x33 TM3 polar (hydrogen bond)
naloxone Y150 3.33x33 TM3 Van der Waals
naloxone M153 3.36x36 TM3 hydrophobic
naloxone M153 3.36x36 TM3 Van der Waals
naloxone K235 5.39x40 TM5 Van der Waals
naloxone W295 6.48x48 TM6 hydrophobic
naloxone W295 6.48x48 TM6 Van der Waals
naloxone I298 6.51x51 TM6 hydrophobic
naloxone V302 6.55x55 TM6 hydrophobic
naloxone V302 6.55x55 TM6 Van der Waals
naloxone W320 7.35x34 TM7 hydrophobic
naloxone W320 7.35x34 TM7 Van der Waals
naloxone I324 7.39x38 TM7 hydrophobic
naloxone I324 7.39x38 TM7 Van der Waals
naloxone Y328 7.43x42 TM7 hydrophobic
naloxone Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x33 3.33x33 Y150
3x36 3.36x36 M153
TM5
5x40 5.39x40 K235
TM6
6x48 6.48x48 W295
6x51 6.51x51 I298
6x55 6.55x55 V302
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328