PDB
9XJW
Resolution
2.5 Å
Released
May 27, 2026
Receptor
GPR119
Class
A
Species
Homo sapiens
Ligand
AS1269574
Function
Agonist (partial)
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
AS1269574 A89 3.36x36 TM3 hydrophobic
AS1269574 V93 3.40x40 TM3 hydrophobic
AS1269574 L94 3.41x41 TM3 hydrophobic
AS1269574 I136 4.56x56 TM4 hydrophobic
AS1269574 L169 5.43x44 TM5 hydrophobic
AS1269574 F174 5.48x48 TM5 hydrophobic
AS1269574 W238 6.48x48 TM6 hydrophobic
AS1269574 L242 6.52x52 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 I H K N D ICL1ECL1 S P S ECL1ICL2 P F R Y L K I M ICL2ECL2 P M F Q Q T A Y K G Q C S F F A V ECL2ICL3 A M A G G Y ICL3ECL3 Q E C H L ECL3C-term G V K K V L T S F L L F L S A R N C G P E R P R E S S C H I V T I S S S E F D G C-term M E S S F S F G V I L A V L A S L I I A T N T L V A V A V L L L G V S L C F T L N L A V A D T L I G V A I S G L L T D Q L S R P T Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q S G F V A G A C I A G L W L V S Y L I G F L P L G I F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G R S P R T P S D F K A L R T V S V L I G S F A L S W T P F L I T G I V Q V A C Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E L Y H V R L Q M A L
Helix box plot — Download: PNG | SVG T N T A I I L S A L V A L I V G F S F S 1 L N L A V A D T L I G V A I S G L L T D 2 L M V T L V S A A A S S T V F A M R L S 3 A G A C I A G L W L V S Y L I G F L P L 4 F F V F L L M A P F F G V C S L T L V F H 5 S V L I G S F A L S W T P F L I T G I V 6 L P N L L S N G V G L L W L Y R E L V 7

GPCRdb(A)
GPCRdb(A)
GPR119
TM3
3x36 3.36x36 A89
3x40 3.40x40 V93
3x41 3.41x41 L94
TM4
4x56 4.56x56 I136
TM5
5x44 5.43x44 L169
5x48 5.48x48 F174
TM6
6x48 6.48x48 W238
6x52 6.52x52 L242