GW9508
SMILES | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 |
InChIKey | DGENZVKCTGIDRZ-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 3 |
Hydrogen bond donors | 2 |
Rotatable bonds | 8 |
Molecular weight (Da) | 347.2 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Structure pdb | 8H4K |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pKi | 7.92 | 7.92 | 7.92 | Guide to Pharmacology |
mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pKi | 7.92 | 7.92 | 7.92 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pIC50 | 7.77 | 7.77 | 7.77 | Guide to Pharmacology |
mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pIC50 | 7.92 | 7.92 | 7.92 | Guide to Pharmacology |
mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pIC50 | 7.77 | 7.77 | 7.77 | ChEMBL |