CORYNANTHINE


SMILES COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O
InChIKey BLGXFZZNTVWLAY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Molecular weight (Da) 354.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.15 5.35 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.5 5.66 5.8 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.0 6.58 7.8 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.0 6.14 7.7 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.0 6.05 6.6 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.94 5.94 5.94 PDSP Ki database
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 5.36 5.36 5.36 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.6 7.28 7.8 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.54 7.9 8.39 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.77 5.98 6.19 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 7.23 7.38 7.45 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.55 9.35 10.4 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 6.88 8.7 9.49 PDSP Ki database
α2B ADA2B Rat Adrenoceptors A pKi 7.0 8.57 9.35 PDSP Ki database
α2C ADA2C North American opossum Adrenoceptors A pKi 7.7 8.9 10.1 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 7.11 8.66 9.49 PDSP Ki database
α1D ADA1D Rat Adrenoceptors A pKi 6.6 6.6 6.6 PDSP Ki database
α1B ADA1B Rat Adrenoceptors A pKi 6.29 6.29 6.29 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.46 5.46 5.46 PDSP Ki database
α2A ADA2A Pig Adrenoceptors A pKi 9.43 9.43 9.43 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.82 5.82 5.82 PDSP Ki database
5-HT1D 5HT1D Dog 5-Hydroxytryptamine A pKi 8.28 8.28 8.28 PDSP Ki database
α2A ADA2A Mouse Adrenoceptors A pKi 7.44 7.44 7.44 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database