GBR-12909


SMILES C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl
InChIKey MIBSKSYCRFWIRU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 10
Molecular weight (Da) 522.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pKi 6.13 6.13 6.13 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.33 5.33 5.33 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 6.79 6.79 6.79 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.44 5.44 5.44 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 7.74 7.74 7.74 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 6.0 6.0 6.0 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 6.57 6.57 6.57 PDSP Ki database
H1 HRH1 Human Histamine A pKi 8.03 8.03 8.03 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 6.96 6.96 6.96 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database