Femoxetine


SMILES CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3
InChIKey OJSFTALXCYKKFQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 311.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.18 8.18 8.18 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.2 8.2 8.2 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.19 8.19 8.19 Drug Central
D2 DRD2 Human Dopamine A pKi 8.21 8.21 8.21 Drug Central
H1 HRH1 Human Histamine A pKi 8.27 8.27 8.27 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.64 5.64 5.64 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.23 6.23 6.23 PDSP Ki database
H1 HRH1 Human Histamine A pKi 5.38 5.38 5.38 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.5 5.5 5.5 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.03 5.03 5.03 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.43 5.43 5.43 PDSP Ki database
5-HT2C A0A4W2GLI9 Hybrid cattle 5-Hydroxytryptamine A pKi 5.72 5.72 5.72 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.04 7.04 7.04 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.82 6.82 6.82 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.66 6.66 6.66 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.33 6.33 6.33 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.4 6.4 6.4 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.15 8.15 8.15 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.17 8.17 8.17 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database