Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

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 DOI
172447279 195129 None 0 Human Functional pEC50 = 9.8 9.8 - 1
Agonist activity at human BB1 in human HEK293T cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB1 in human HEK293T cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay
ChEMBL 1103 32 13 12 -0.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O 10.1021/acs.jmedchem.3c00323
CHEMBL5397144 195129 None 0 Human Functional pEC50 = 9.8 9.8 - 1
Agonist activity at human BB1 in human HEK293T cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB1 in human HEK293T cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay
ChEMBL 1103 32 13 12 -0.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O 10.1021/acs.jmedchem.3c00323
CHEMBL525577 218143 None 0 Human Functional pEC50 = 9.3 9.3 -9 3
Agonist activity at recombinant neuromedin B receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant neuromedin B receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O 10.1016/j.bmcl.2008.09.033
CHEMBL403317 214990 None 22 Human Functional pEC50 = 6.9 6.9 -169 4
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CN)[C@@H](C)O)C(N)=O 10.1021/jm0210921
44333515 4747 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL103756 4747 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
90663970 106847 None 0 Human Functional pEC50 = 4.8 4.8 -12 3
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL 553 14 5 4 2.5 NC(=O)CC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1021/jm0210921
CHEMBL3144503 106847 None 0 Human Functional pEC50 = 4.8 4.8 -12 3
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL 553 14 5 4 2.5 NC(=O)CC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1021/jm0210921
44333515 4747 None 0 Human Functional pEC50 = 7.8 7.8 - 1
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL103756 4747 None 0 Human Functional pEC50 = 7.8 7.8 - 1
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
90663965 106842 None 0 Human Functional pEC50 = 4.7 4.7 -13 3
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL 587 14 5 4 3.2 NC(=O)CC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1021/jm0210921
CHEMBL3144498 106842 None 0 Human Functional pEC50 = 4.7 4.7 -13 3
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL 587 14 5 4 3.2 NC(=O)CC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1021/jm0210921
44333515 4747 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL103756 4747 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
44300286 96612 None 0 Human Functional pEC50 = 6.5 6.5 -3 3
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL 1106 31 11 12 2.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)O 10.1021/jm0210921
CHEMBL262992 96612 None 0 Human Functional pEC50 = 6.5 6.5 -3 3
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL 1106 31 11 12 2.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)O 10.1021/jm0210921
CHEMBL438926 216272 None 15 Human Functional pEC50 = 5.5 5.5 -93 3
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm0210921
44334117 107551 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 605 8 4 3 7.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL318548 107551 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 605 8 4 3 7.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
3622597 197871 None 14 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assayAntagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assay
ChEMBL 384 1 2 3 6.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL552189 197871 None 14 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assayAntagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assay
ChEMBL 384 1 2 3 6.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44250209 198943 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assayAntagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assay
ChEMBL 426 1 2 3 6.8 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563374 198943 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assayAntagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assay
ChEMBL 426 1 2 3 6.8 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL403317 214990 None 22 Human Functional pKi = 10.2 10.2 -169 4
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CN)[C@@H](C)O)C(N)=O 10.1016/s0960-894x(98)00462-4
621 3035 None 27 Human Functional pKi = 9.8 9.8 117 6
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10.1016/s0960-894x(98)00462-4
9937534 3035 None 27 Human Functional pKi = 9.8 9.8 117 6
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10.1016/s0960-894x(98)00462-4
CHEMBL329650 3035 None 27 Human Functional pKi = 9.8 9.8 117 6
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10.1016/s0960-894x(98)00462-4
626 3036 None 31 Human Functional pKi = 9.8 9.8 125 2
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 10.1016/s0960-894x(98)00462-4
9829828 3036 None 31 Human Functional pKi = 9.8 9.8 125 2
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 10.1016/s0960-894x(98)00462-4
CHEMBL405908 3036 None 31 Human Functional pKi = 9.8 9.8 125 2
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 10.1016/s0960-894x(98)00462-4
44321212 111491 None 0 Human Functional pKi = 9.5 9.5 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 598 10 4 6 6.1 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccc([N+](=O)[O-])cc2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL327388 111491 None 0 Human Functional pKi = 9.5 9.5 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 598 10 4 6 6.1 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccc([N+](=O)[O-])cc2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321034 111576 None 0 Human Functional pKi = 9.5 9.5 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 534 8 4 4 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(C#N)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL327840 111576 None 0 Human Functional pKi = 9.5 9.5 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 534 8 4 4 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(C#N)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321211 208637 None 0 Human Functional pKi = 9.4 9.4 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 553 9 4 4 6.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccccc2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL86370 208637 None 0 Human Functional pKi = 9.4 9.4 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 553 9 4 4 6.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccccc2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321244 208519 None 0 Human Functional pKi = 9.4 9.4 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 613 11 4 6 6.2 COc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1OC 10.1016/s0960-894x(98)00462-4
CHEMBL85400 208519 None 0 Human Functional pKi = 9.4 9.4 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 613 11 4 6 6.2 COc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1OC 10.1016/s0960-894x(98)00462-4
44321006 106007 None 0 Human Functional pKi = 9.3 9.3 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 583 10 4 5 6.2 COc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
CHEMBL312926 106007 None 0 Human Functional pKi = 9.3 9.3 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 583 10 4 5 6.2 COc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
44321039 168266 None 0 Human Functional pKi = 9.3 9.3 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 596 10 4 5 6.3 CN(C)c1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
CHEMBL433143 168266 None 0 Human Functional pKi = 9.3 9.3 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 596 10 4 5 6.3 CN(C)c1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
44321245 208510 None 0 Human Functional pKi = 9.2 9.2 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 597 11 4 5 6.6 CCOc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
CHEMBL85291 208510 None 0 Human Functional pKi = 9.2 9.2 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 597 11 4 5 6.6 CCOc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
44321158 208873 None 0 Human Functional pKi = 9.2 9.2 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 569 9 5 5 5.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccc(O)cc2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL87846 208873 None 0 Human Functional pKi = 9.2 9.2 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 569 9 5 5 5.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccc(O)cc2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321246 106122 None 0 Human Functional pKi = 9.0 9.0 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL313346 106122 None 0 Human Functional pKi = 9.0 9.0 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321117 106028 None 0 Human Functional pKi = 8.8 8.8 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 595 10 4 4 7.3 CC(C)c1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
CHEMBL313030 106028 None 0 Human Functional pKi = 8.8 8.8 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 595 10 4 4 7.3 CC(C)c1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
44321035 209173 None 0 Human Functional pKi = 6.7 6.7 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL89813 209173 None 0 Human Functional pKi = 6.7 6.7 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
101835328 704 None 34 Human Functional pKi = 8.7 8.7 -6 3
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
16133800 704 None 34 Human Functional pKi = 8.7 8.7 -6 3
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
16201612 704 None 34 Human Functional pKi = 8.7 8.7 -6 3
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
616 704 None 34 Human Functional pKi = 8.7 8.7 -6 3
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
91898967 704 None 34 Human Functional pKi = 8.7 8.7 -6 3
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
CHEMBL437027 704 None 34 Human Functional pKi = 8.7 8.7 -6 3
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
DB11724 704 None 34 Human Functional pKi = 8.7 8.7 -6 3
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
44321083 111541 None 0 Human Functional pKi = 8.7 8.7 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 577 8 4 3 7.0 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL327678 111541 None 0 Human Functional pKi = 8.7 8.7 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 577 8 4 3 7.0 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL314375 213639 None 0 Human Functional pKi = 8.7 8.7 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(C)C)C(N)=O 10.1016/s0960-894x(98)00462-4
44321084 107181 None 0 Human Functional pKi = 8.6 8.6 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 543 8 4 3 6.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL316085 107181 None 0 Human Functional pKi = 8.6 8.6 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 543 8 4 3 6.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321037 209311 None 1 Human Functional pKi = 8.5 8.5 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 577 8 4 3 6.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL90614 209311 None 1 Human Functional pKi = 8.5 8.5 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 577 8 4 3 6.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321085 208761 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 509 8 4 3 5.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccccc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL87079 208761 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 509 8 4 3 5.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccccc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321036 209164 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 583 10 4 5 6.2 COc1ccccc1C1(CNC(=O)[C@](C)(Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc([N+](=O)[O-])cc2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL89734 209164 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 583 10 4 5 6.2 COc1ccccc1C1(CNC(=O)[C@](C)(Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc([N+](=O)[O-])cc2)CCCCC1 10.1016/s0960-894x(98)00462-4
5311352 3033 None 9 Human Functional pKi = 8.2 8.2 -2 2
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/s0960-894x(98)00462-4
620 3033 None 9 Human Functional pKi = 8.2 8.2 -2 2
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/s0960-894x(98)00462-4
CHEMBL86828 3033 None 9 Human Functional pKi = 8.2 8.2 -2 2
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/s0960-894x(98)00462-4
612 1776 None 0 Human Functional pKi = 8.0 8.0 - 1
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
CHEMBL413196 1776 None 0 Human Functional pKi = 8.0 8.0 - 1
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
44321157 208898 None 0 Human Functional pKi = 8.0 8.0 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 551 9 4 3 6.8 CC(C)c1ccc(NC(=O)N[C@@](C)(Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
CHEMBL88010 208898 None 0 Human Functional pKi = 8.0 8.0 - 0
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 551 9 4 3 6.8 CC(C)c1ccc(NC(=O)N[C@@](C)(Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
6176 573 None 0 Human Functional pIC50 = 5.2 5.2 -3388 5
UnclassifiedUnclassified
Guide to Pharmacology 895 23 7 8 4.8 CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C 20096642
6176 573 None 0 Human Functional pIC50 = 5.2 5.2 -3388 5
UnclassifiedUnclassified
Guide to Pharmacology 895 23 7 8 4.8 CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C 23892571
73755180 573 None 0 Human Functional pIC50 = 5.2 5.2 -3388 5
UnclassifiedUnclassified
Guide to Pharmacology 895 23 7 8 4.8 CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C 20096642
73755180 573 None 0 Human Functional pIC50 = 5.2 5.2 -3388 5
UnclassifiedUnclassified
Guide to Pharmacology 895 23 7 8 4.8 CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C 23892571
3889 2131 None 0 Rat Functional pIC50 = 5.8 5.8 -3311 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11463790
635 1450 None 0 Rat Functional pIC50 = 6 6.0 -2 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7901752
6172 1451 None 0 Human Functional pIC50 = 6.3 6.3 10 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19463875
635 1450 None 0 Human Functional pIC50 = 6.4 6.4 2 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19463875
155817490 2307 None 0 Human Functional pIC50 = 6.5 6.5 -2 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
6168 2307 None 0 Human Functional pIC50 = 6.5 6.5 -2 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
155817491 1778 None 0 Rat Functional pIC50 = 6.6 6.6 -1288 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6175 1778 None 0 Rat Functional pIC50 = 6.6 6.6 -1288 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
155817490 2307 None 0 Rat Functional pIC50 = 6.8 6.8 -1 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6168 2307 None 0 Rat Functional pIC50 = 6.8 6.8 -1 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
155817491 1778 None 0 Human Functional pIC50 = 6.9 6.9 -758 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6175 1778 None 0 Human Functional pIC50 = 6.9 6.9 -758 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
621 3035 None 27 Rat Functional pIC50 = 7.4 7.4 -117 6
UnclassifiedUnclassified
Guide to Pharmacology 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10454496
9937534 3035 None 27 Rat Functional pIC50 = 7.4 7.4 -117 6
UnclassifiedUnclassified
Guide to Pharmacology 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10454496
CHEMBL329650 3035 None 27 Rat Functional pIC50 = 7.4 7.4 -117 6
UnclassifiedUnclassified
Guide to Pharmacology 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10454496
155817489 3115 None 0 Rat Functional pIC50 = 7.7 7.7 -8 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6166 3115 None 0 Rat Functional pIC50 = 7.7 7.7 -8 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
22146595 3290 None 0 Human Functional pIC50 = 8.6 8.6 -2 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
618 3290 None 0 Human Functional pIC50 = 8.6 8.6 -2 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
101835328 704 None 34 Human Functional pIC50 = 8.6 8.6 -6 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
16133800 704 None 34 Human Functional pIC50 = 8.6 8.6 -6 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
16201612 704 None 34 Human Functional pIC50 = 8.6 8.6 -6 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
616 704 None 34 Human Functional pIC50 = 8.6 8.6 -6 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
91898967 704 None 34 Human Functional pIC50 = 8.6 8.6 -6 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
CHEMBL437027 704 None 34 Human Functional pIC50 = 8.6 8.6 -6 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
DB11724 704 None 34 Human Functional pIC50 = 8.6 8.6 -6 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
155817489 3115 None 0 Human Functional pIC50 = 8.6 8.6 8 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6166 3115 None 0 Human Functional pIC50 = 8.6 8.6 8 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
155817488 3327 None 0 Rat Functional pIC50 = 9.0 9.0 -4 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
57340152 3327 None 0 Rat Functional pIC50 = 9.0 9.0 -4 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6165 3327 None 0 Rat Functional pIC50 = 9.0 9.0 -4 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
621 3035 None 27 Human Functional pIC50 = 9.5 9.5 117 6
UnclassifiedUnclassified
Guide to Pharmacology 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 19463875
9937534 3035 None 27 Human Functional pIC50 = 9.5 9.5 117 6
UnclassifiedUnclassified
Guide to Pharmacology 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 19463875
CHEMBL329650 3035 None 27 Human Functional pIC50 = 9.5 9.5 117 6
UnclassifiedUnclassified
Guide to Pharmacology 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 19463875
626 3036 None 31 Human Functional pIC50 = 9.5 9.5 125 2
UnclassifiedUnclassified
Guide to Pharmacology 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 19463875
9829828 3036 None 31 Human Functional pIC50 = 9.5 9.5 125 2
UnclassifiedUnclassified
Guide to Pharmacology 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 19463875
CHEMBL405908 3036 None 31 Human Functional pIC50 = 9.5 9.5 125 2
UnclassifiedUnclassified
Guide to Pharmacology 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 19463875
632 1478 None 0 Human Functional pIC50 = 9.6 9.6 -4 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6163 2769 None 0 Human Functional pIC50 = 9.6 9.6 67 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
155817488 3327 None 0 Human Functional pIC50 = 9.7 9.7 4 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
57340152 3327 None 0 Human Functional pIC50 = 9.7 9.7 4 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6165 3327 None 0 Human Functional pIC50 = 9.7 9.7 4 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
3840 1481 None 0 Human Functional pIC50 > 5 5.0 -7762 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19463875
624 2130 None 0 Rat Functional pIC50 > 5 5.0 -7943 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11463790
49871766 2557 None 36 Human Functional pIC50 > 5 5.0 -6165 5
UnclassifiedUnclassified
Guide to Pharmacology 444 6 2 4 4.5 FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F 21036912
49871766 2557 None 36 Human Functional pIC50 > 5 5.0 -6165 5
UnclassifiedUnclassified
Guide to Pharmacology 444 6 2 4 4.5 FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F 23892571
6170 2557 None 36 Human Functional pIC50 > 5 5.0 -6165 5
UnclassifiedUnclassified
Guide to Pharmacology 444 6 2 4 4.5 FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F 21036912
6170 2557 None 36 Human Functional pIC50 > 5 5.0 -6165 5
UnclassifiedUnclassified
Guide to Pharmacology 444 6 2 4 4.5 FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F 23892571
CHEMBL1672354 2557 None 36 Human Functional pIC50 > 5 5.0 -6165 5
UnclassifiedUnclassified
Guide to Pharmacology 444 6 2 4 4.5 FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F 21036912
CHEMBL1672354 2557 None 36 Human Functional pIC50 > 5 5.0 -6165 5
UnclassifiedUnclassified
Guide to Pharmacology 444 6 2 4 4.5 FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F 23892571


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
117745230 142619 None 0 Rat Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1523 40 17 21 -3.0 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)O)C(N)=O nan
CHEMBL3890803 142619 None 0 Rat Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1523 40 17 21 -3.0 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)O)C(N)=O nan
CHEMBL3944194 214934 None 0 Rat Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(N)=O nan
134145000 150376 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1501 43 16 22 -3.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NCc1ccc(C(=O)C(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3952732 150376 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1501 43 16 22 -3.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NCc1ccc(C(=O)C(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
134156977 154069 None 0 Rat Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1604 43 17 21 -2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CC[C@H](CNC(=O)[C@H]2CC[C@H](CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)CC2)CC1)C(C)C)C(N)=O nan
CHEMBL3983862 154069 None 0 Rat Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1604 43 17 21 -2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CC[C@H](CNC(=O)[C@H]2CC[C@H](CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)CC2)CC1)C(C)C)C(N)=O nan
626 3036 None 31 Human Binding pIC50 = 9.2 9.2 5 2
Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3
ChEMBL 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 10.1016/s0960-894x(98)00462-4
9829828 3036 None 31 Human Binding pIC50 = 9.2 9.2 5 2
Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3
ChEMBL 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 10.1016/s0960-894x(98)00462-4
CHEMBL405908 3036 None 31 Human Binding pIC50 = 9.2 9.2 5 2
Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3
ChEMBL 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 10.1016/s0960-894x(98)00462-4
CHEMBL403317 214990 None 22 Rat Binding pIC50 = 9.2 9.2 - 2
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CN)[C@@H](C)O)C(N)=O nan
117745218 150213 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1536 41 17 21 -3.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c(Cl)c1)C(C)C)C(N)=O nan
CHEMBL3951222 150213 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1536 41 17 21 -3.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c(Cl)c1)C(C)C)C(N)=O nan
117745209 152990 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1516 42 17 21 -4.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(C(=O)NCCNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3974709 152990 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1516 42 17 21 -4.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(C(=O)NCCNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
11389266 161899 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL 1303 44 17 18 -2.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCC(=O)Nc1ccc(CC(CNCCN)CNCCN)cc1)C(C)C)C(N)=O 10.1021/jm049437y
CHEMBL414307 161899 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL 1303 44 17 18 -2.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCC(=O)Nc1ccc(CC(CNCCN)CNCCN)cc1)C(C)C)C(N)=O 10.1021/jm049437y
CHEMBL413893 215559 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(N)=O 10.1021/jm049437y
117745205 150518 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1502 41 17 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)c1ccc(NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3953912 150518 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1502 41 17 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)c1ccc(NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
87217693 151362 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1489 41 16 21 -3.2 COc1cc(C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)ccc1CNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 nan
CHEMBL3960359 151362 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1489 41 16 21 -3.2 COc1cc(C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)ccc1CNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 nan
134153902 152644 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1592 42 17 21 -1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(-c2ccc(NC(=O)CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)cc2C)cc1)C(C)C)C(N)=O nan
CHEMBL3971676 152644 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1592 42 17 21 -1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(-c2ccc(NC(=O)CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)cc2C)cc1)C(C)C)C(N)=O nan
87217854 144334 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1516 41 16 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(N(C)C(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3904706 144334 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1516 41 16 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(N(C)C(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
16154477 150462 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1502 41 17 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3953323 150462 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1502 41 17 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
87217796 149035 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1502 41 17 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1cccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c1)C(C)C)C(N)=O nan
CHEMBL3941990 149035 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1502 41 17 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1cccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c1)C(C)C)C(N)=O nan
CHEMBL2371725 212577 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL None None None CSCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C(CNCCN)CNCCN)C(C)C)C(N)=O 10.1021/jm049437y
134131431 142462 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1583 40 15 23 -3.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)Cn1c(=O)n(C2CCN(C(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)CC2)c2ccccc21)C(C)C)C(N)=O nan
CHEMBL3889538 142462 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1583 40 15 23 -3.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)Cn1c(=O)n(C2CCN(C(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)CC2)c2ccccc21)C(C)C)C(N)=O nan
87217644 143804 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1489 42 16 21 -3.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(OCCNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3900523 143804 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1489 42 16 21 -3.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(OCCNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
134154031 152946 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1517 48 21 23 -8.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3974250 152946 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1517 48 21 23 -8.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
44333639 4729 None 0 Human Binding pIC50 = 5 5.0 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 526 7 4 5 4.6 CC(C)(CNC(=O)C1(NC(=O)Nc2ccc([N+](=O)[O-])cc2)CCc2[nH]c3ccccc3c2C1)c1ccccn1 10.1016/j.bmcl.2004.04.045
CHEMBL103594 4729 None 0 Human Binding pIC50 = 5 5.0 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 526 7 4 5 4.6 CC(C)(CNC(=O)C1(NC(=O)Nc2ccc([N+](=O)[O-])cc2)CCc2[nH]c3ccccc3c2C1)c1ccccn1 10.1016/j.bmcl.2004.04.045
45271538 197768 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 398 1 1 3 6.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2C 10.1016/j.bmcl.2009.05.124
CHEMBL551511 197768 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 398 1 1 3 6.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2C 10.1016/j.bmcl.2009.05.124
45273304 198361 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 386 1 3 4 5.4 CC1(C)CC(=O)C2=C(C1)Nc1ccc(O)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL559093 198361 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 386 1 3 4 5.4 CC1(C)CC(=O)C2=C(C1)Nc1ccc(O)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
45273305 198933 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 413 2 3 4 4.8 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(N)=O)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL563295 198933 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 413 2 3 4 4.8 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(N)=O)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
45272454 198971 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 342 1 2 3 5.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CCC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563540 198971 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 342 1 2 3 5.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CCC1=O)N2 10.1016/j.bmcl.2009.05.124
45267289 198984 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 414 2 3 4 5.4 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(=O)O)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL563633 198984 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 414 2 3 4 5.4 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(=O)O)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
44333866 164395 None 0 Human Binding pIC50 = 6 6.0 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 641 8 4 3 8.5 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cc(F)ccc3c2C1F 10.1016/j.bmcl.2004.04.045
CHEMBL421216 164395 None 0 Human Binding pIC50 = 6 6.0 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 641 8 4 3 8.5 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cc(F)ccc3c2C1F 10.1016/j.bmcl.2004.04.045
CHEMBL2371724 212576 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C(CNCCN)CNCCN)C(C)C)C(N)=O 10.1021/jm049437y
45267292 198445 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 362 2 2 4 5.2 COc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC(C)(C)C2 10.1016/j.bmcl.2009.05.124
CHEMBL559859 198445 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 362 2 2 4 5.2 COc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC(C)(C)C2 10.1016/j.bmcl.2009.05.124
44334408 5014 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 589 6 4 3 6.6 O=C(Nc1ccc(C(F)(F)F)cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL105068 5014 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 589 6 4 3 6.6 O=C(Nc1ccc(C(F)(F)F)cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
134157223 153668 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1495 42 16 22 -5.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CN1CCN(CCNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(C)C)C(N)=O nan
CHEMBL3980433 153668 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1495 42 16 22 -5.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CN1CCN(CCNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(C)C)C(N)=O nan
134147546 149722 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1614 52 18 24 -6.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCCOCCNC(=O)CN1CCN(C(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)CC1)C(C)C)C(N)=O nan
CHEMBL3947283 149722 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1614 52 18 24 -6.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCCOCCNC(=O)CN1CCN(C(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)CC1)C(C)C)C(N)=O nan
134135762 144589 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1599 50 20 24 -7.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CN1CCN(CCNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)CC1)C(C)C)C(N)=O nan
CHEMBL3906914 144589 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1599 50 20 24 -7.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CN1CCN(CCNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)CC1)C(C)C)C(N)=O nan
4604199 197313 None 19 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 350 1 2 3 5.4 Cc1ccc2c(c1)NC(c1ccccc1F)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL549567 197313 None 19 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 350 1 2 3 5.4 Cc1ccc2c(c1)NC(c1ccccc1F)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
45269876 197872 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 454 2 2 4 6.6 CC1(C)CC(=O)C2=C(C1)Nc1ccc(OC(F)(F)F)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL552191 197872 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 454 2 2 4 6.6 CC1(C)CC(=O)C2=C(C1)Nc1ccc(OC(F)(F)F)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
45271526 198848 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 395 1 2 4 5.6 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C#N)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL562708 198848 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 395 1 2 4 5.6 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C#N)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
134149621 148718 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1449 45 16 19 -2.2 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
CHEMBL3939368 148718 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1449 45 16 19 -2.2 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
45273323 198155 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 356 1 2 3 5.4 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CCCC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL556898 198155 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 356 1 2 3 5.4 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CCCC1=O)N2 10.1016/j.bmcl.2009.05.124
134151148 151670 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1535 41 16 20 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1cccc(-c2ccc(CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)cc2)c1)C(C)C)C(N)=O nan
CHEMBL3963362 151670 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1535 41 16 20 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1cccc(-c2ccc(CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)cc2)c1)C(C)C)C(N)=O nan
5311352 3033 None 9 Rat Binding pIC50 = 6.8 6.8 - 1
Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
620 3033 None 9 Rat Binding pIC50 = 6.8 6.8 - 1
Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
CHEMBL86828 3033 None 9 Rat Binding pIC50 = 6.8 6.8 - 1
Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
45267295 198446 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 440 4 1 3 7.2 CCCCN1c2cc(C)ccc2NC2=C(C(=O)CC(C)(C)C2)C1c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL559860 198446 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 440 4 1 3 7.2 CCCCN1c2cc(C)ccc2NC2=C(C(=O)CC(C)(C)C2)C1c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
134152521 151626 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1360 37 15 19 -3.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
CHEMBL3963000 151626 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1360 37 15 19 -3.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
45270715 198975 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 398 1 1 3 6.0 Cc1ccc2c(c1)N(C)C(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563564 198975 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 398 1 1 3 6.0 Cc1ccc2c(c1)N(C)C(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
134151766 153248 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1397 40 16 20 -4.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
CHEMBL3976771 153248 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1397 40 16 20 -4.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
45270716 194884 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 412 2 1 3 6.4 CCN1c2cc(C)ccc2NC2=C(C(=O)CC(C)(C)C2)C1c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL538178 194884 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 412 2 1 3 6.4 CCN1c2cc(C)ccc2NC2=C(C(=O)CC(C)(C)C2)C1c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
44334409 5015 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 665 10 4 7 6.0 CCOC(=O)c1cc(NC(=O)NC2(C(=O)NCC3(c4ccccn4)CCCCC3)CCc3[nH]c4ccccc4c3C2)cc(C(=O)OCC)c1 10.1016/j.bmcl.2004.04.045
CHEMBL105069 5015 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 665 10 4 7 6.0 CCOC(=O)c1cc(NC(=O)NC2(C(=O)NCC3(c4ccccn4)CCCCC3)CCc3[nH]c4ccccc4c3C2)cc(C(=O)OCC)c1 10.1016/j.bmcl.2004.04.045
44333537 111640 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 689 9 4 4 8.8 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cccc(OC(F)(F)F)c3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL328166 111640 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 689 9 4 4 8.8 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cccc(OC(F)(F)F)c3c2C1 10.1016/j.bmcl.2004.04.045
134133036 144628 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1586 51 23 23 -7.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3907272 144628 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1586 51 23 23 -7.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
11434815 96989 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL 1285 44 17 17 -2.2 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCC(=O)Nc1ccc(CC(CNCCN)CNCCN)cc1)C(C)C)C(N)=O 10.1021/jm049437y
CHEMBL266079 96989 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL 1285 44 17 17 -2.2 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCC(=O)Nc1ccc(CC(CNCCN)CNCCN)cc1)C(C)C)C(N)=O 10.1021/jm049437y
134135229 144310 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1558 51 21 23 -7.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3904512 144310 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1558 51 21 23 -7.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
87217489 145044 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1516 41 17 21 -3.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c(C)c1)C(C)C)C(N)=O nan
CHEMBL3910471 145044 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1516 41 17 21 -3.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c(C)c1)C(C)C)C(N)=O nan
87217658 153413 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1754 44 17 22 -0.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](NC(=O)CNC(=O)CN5CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC5)CC[C@]4(C)[C@H]3CC(=O)[C@@]21C)C(C)C)C(N)=O nan
CHEMBL3978233 153413 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1754 44 17 22 -0.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](NC(=O)CNC(=O)CN5CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC5)CC[C@]4(C)[C@H]3CC(=O)[C@@]21C)C(C)C)C(N)=O nan
87217674 148123 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1465 40 16 20 -3.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CC[C@H](CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(C)C)C(N)=O nan
CHEMBL3934601 148123 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1465 40 16 20 -3.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CC[C@H](CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(C)C)C(N)=O nan
117745216 143102 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1517 42 18 22 -4.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NNC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3894747 143102 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1517 42 18 22 -4.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NNC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
134153217 152521 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1457 46 19 21 -6.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3970735 152521 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1457 46 19 21 -6.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
45269883 197997 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 378 2 2 4 5.9 CSc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC(C)(C)C2 10.1016/j.bmcl.2009.05.124
CHEMBL554477 197997 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 378 2 2 4 5.9 CSc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC(C)(C)C2 10.1016/j.bmcl.2009.05.124
45270721 197881 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 462 3 2 4 6.8 COc1ccc(C2CC(=O)C3=C(C2)Nc2ccc(C)cc2NC3c2c(F)cccc2Cl)cc1 10.1016/j.bmcl.2009.05.124
CHEMBL552257 197881 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 462 3 2 4 6.8 COc1ccc(C2CC(=O)C3=C(C2)Nc2ccc(C)cc2NC3c2c(F)cccc2Cl)cc1 10.1016/j.bmcl.2009.05.124
CHEMBL3894546 214885 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
44333806 4590 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 683 8 4 3 8.6 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cc(Br)ccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL102647 4590 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 683 8 4 3 8.6 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cc(Br)ccc3c2C1 10.1016/j.bmcl.2004.04.045
45269877 198327 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 400 2 2 4 5.7 COc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL558803 198327 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 400 2 2 4 5.7 COc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44334154 5094 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 563 7 4 4 5.8 CC(=O)c1cccc(NC(=O)NC2(C(=O)NCC3(c4ccccn4)CCCCC3)CCc3[nH]c4ccccc4c3C2)c1 10.1016/j.bmcl.2004.04.045
CHEMBL105543 5094 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 563 7 4 4 5.8 CC(=O)c1cccc(NC(=O)NC2(C(=O)NCC3(c4ccccn4)CCCCC3)CCc3[nH]c4ccccc4c3C2)c1 10.1016/j.bmcl.2004.04.045
134147351 149664 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1558 51 21 23 -7.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3946856 149664 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1558 51 21 23 -7.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
45269049 198864 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 392 1 2 3 6.4 Cc1ccc2c(c1)NC(c1ccccc1Cl)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL562834 198864 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 392 1 2 3 6.4 Cc1ccc2c(c1)NC(c1ccccc1Cl)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44333515 4747 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL103756 4747 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
45267305 198535 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 404 2 2 4 6.5 CSc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC1(CCCC1)C2 10.1016/j.bmcl.2009.05.124
CHEMBL560655 198535 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 404 2 2 4 6.5 CSc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC1(CCCC1)C2 10.1016/j.bmcl.2009.05.124
45269034 198969 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 400 1 2 3 6.2 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563531 198969 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 400 1 2 3 6.2 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
45272445 197619 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 368 1 2 3 5.5 Cc1ccc2c(c1)NC(c1c(F)cccc1F)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL550367 197619 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 368 1 2 3 5.5 Cc1ccc2c(c1)NC(c1c(F)cccc1F)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
45269043 198788 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 410 1 2 3 6.5 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL562376 198788 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 410 1 2 3 6.5 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
2876782 199069 None 11 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 366 1 2 3 5.9 Cc1ccc2c(c1)NC(c1ccccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL564151 199069 None 11 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 366 1 2 3 5.9 Cc1ccc2c(c1)NC(c1ccccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44333515 4747 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL103756 4747 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
10124999 153520 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1467 45 16 20 -2.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
CHEMBL3979188 153520 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1467 45 16 20 -2.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
87237371 149024 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1772 44 19 23 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@H](NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)C[C@H]1C[C@H]3O)C(C)C)C(N)=O nan
CHEMBL3941920 149024 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1772 44 19 23 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@H](NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)C[C@H]1C[C@H]3O)C(C)C)C(N)=O nan
CHEMBL3967904 214959 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H]1CCCN1)C(C)C)C(N)=O nan
117745207 144155 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1494 40 16 21 -4.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)C1CCN(C(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(C)C)C(N)=O nan
CHEMBL3903246 144155 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1494 40 16 21 -4.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)C1CCN(C(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(C)C)C(N)=O nan
87217686 151570 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1756 44 18 22 -0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](NC(=O)CNC(=O)CN5CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC5)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C)C(C)C)C(N)=O nan
CHEMBL3962308 151570 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1756 44 18 22 -0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](NC(=O)CNC(=O)CN5CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC5)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C)C(C)C)C(N)=O nan
44250209 198943 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 426 1 2 3 6.8 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563374 198943 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 426 1 2 3 6.8 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
3622597 197871 None 14 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 384 1 2 3 6.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL552189 197871 None 14 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 384 1 2 3 6.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
45273328 198855 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 422 2 2 4 6.4 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(c3ccco3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL562770 198855 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 422 2 2 4 6.4 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(c3ccco3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44334155 5192 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 605 7 4 4 6.5 O=C(Nc1ccc(OC(F)(F)F)cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL106065 5192 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 605 7 4 4 6.5 O=C(Nc1ccc(OC(F)(F)F)cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
44334117 107551 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 605 8 4 3 7.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL318548 107551 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 605 8 4 3 7.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
134143221 145573 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1603 54 20 24 -7.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCCOCCNC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3914573 145573 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1603 54 20 24 -7.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCCOCCNC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
44333815 159320 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 563 8 4 3 6.7 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL409885 159320 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 563 8 4 3 6.7 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
5311352 3033 None 9 Human Binding pIC50 = 6.5 6.5 - 1
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/j.bmcl.2004.04.045
620 3033 None 9 Human Binding pIC50 = 6.5 6.5 - 1
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/j.bmcl.2004.04.045
CHEMBL86828 3033 None 9 Human Binding pIC50 = 6.5 6.5 - 1
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/j.bmcl.2004.04.045
44333512 4697 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 673 8 4 3 8.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cccc(C(F)(F)F)c3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL103430 4697 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 673 8 4 3 8.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cccc(C(F)(F)F)c3c2C1 10.1016/j.bmcl.2004.04.045
45273296 199086 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 438 1 2 3 6.7 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(F)(F)F)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL564278 199086 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 438 1 2 3 6.7 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(F)(F)F)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
44334136 5032 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 527 6 4 3 5.4 O=C(NC1CCCCC1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL105154 5032 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 527 6 4 3 5.4 O=C(NC1CCCCC1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
44317781 208165 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 565 8 4 3 7.0 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC(C)(C)c2ccccn2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL82410 208165 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 565 8 4 3 7.0 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC(C)(C)c2ccccn2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
45272451 197646 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 370 1 2 3 5.6 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL550558 197646 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 370 1 2 3 5.6 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
134137917 147859 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1411 41 16 20 -4.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
CHEMBL3932563 147859 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1411 41 16 20 -4.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
45272456 197649 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 444 1 2 3 6.9 Cc1ccc2c(c1)NC(c1c(F)cccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL550567 197649 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 444 1 2 3 6.9 Cc1ccc2c(c1)NC(c1c(F)cccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
45271543 197828 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 475 3 2 4 6.8 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(c3ccc(N(C)C)cc3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL551917 197828 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 475 3 2 4 6.8 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(c3ccc(N(C)C)cc3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44334156 108301 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 549 6 4 3 6.2 Cc1cccc(C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL319705 108301 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 549 6 4 3 6.2 Cc1cccc(C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
45269039 198733 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 377 2 2 5 5.1 Cc1ccc2c(c1)NC(c1ccccc1[N+](=O)[O-])C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL561979 198733 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 377 2 2 5 5.1 Cc1ccc2c(c1)NC(c1ccccc1[N+](=O)[O-])C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
134139924 146681 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1599 54 21 23 -5.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3923123 146681 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1599 54 21 23 -5.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
87217835 150264 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1459 40 16 20 -3.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3951758 150264 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1459 40 16 20 -3.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
134146430 149322 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1600 53 21 23 -6.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3944228 149322 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1600 53 21 23 -6.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
44334387 4699 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 580 7 4 5 5.8 Cc1cc([N+](=O)[O-])ccc1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL103439 4699 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 580 7 4 5 5.8 Cc1cc([N+](=O)[O-])ccc1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
45273329 198228 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 458 2 2 4 7.4 Cc1ccc2c(c1)NC(c1ccccc1SC(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL557707 198228 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 458 2 2 4 7.4 Cc1ccc2c(c1)NC(c1ccccc1SC(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL3982672 214981 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CC1CCCCC1)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
44333532 4343 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 619 8 4 3 8.2 Cc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL101026 4343 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 619 8 4 3 8.2 Cc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
2883854 198667 None 7 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 332 1 2 3 5.2 Cc1ccc2c(c1)NC(c1ccccc1)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL561518 198667 None 7 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 332 1 2 3 5.2 Cc1ccc2c(c1)NC(c1ccccc1)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
134157363 153962 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1400 44 18 20 -6.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3982939 153962 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1400 44 18 20 -6.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
44333533 4172 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 633 8 4 3 8.7 Cc1ccc2[nH]c3c(c2c1)C(C)C(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL100065 4172 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 633 8 4 3 8.7 Cc1ccc2[nH]c3c(c2c1)C(C)C(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
25025860 569 None 23 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation counting
ChEMBL 333 7 1 2 5.2 CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C 10.1016/j.bmcl.2010.02.076
6188 569 None 23 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation counting
ChEMBL 333 7 1 2 5.2 CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C 10.1016/j.bmcl.2010.02.076
CHEMBL1091720 569 None 23 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation counting
ChEMBL 333 7 1 2 5.2 CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C 10.1016/j.bmcl.2010.02.076
CHEMBL3901298 214899 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(C)C)C(N)=O nan
CHEMBL3929807 214921 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC1CCCCC1)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
44333533 4172 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 633 8 4 3 8.7 Cc1ccc2[nH]c3c(c2c1)C(C)C(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL100065 4172 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 633 8 4 3 8.7 Cc1ccc2[nH]c3c(c2c1)C(C)C(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
44334388 4700 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 566 7 4 5 5.5 O=C(Nc1ccc([N+](=O)[O-])cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL103440 4700 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 566 7 4 5 5.5 O=C(Nc1ccc([N+](=O)[O-])cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
45273322 199005 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 398 2 2 3 6.3 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C(C)C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563752 199005 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 398 2 2 3 6.3 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C(C)C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
4078100 199076 None 11 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 404 1 2 3 6.4 CC1(C)CC(=O)C2=C(C1)Nc1ccc(Cl)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL564193 199076 None 11 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 404 1 2 3 6.4 CC1(C)CC(=O)C2=C(C1)Nc1ccc(Cl)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
44333754 5116 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 551 7 4 4 5.6 COc1ccccc1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL105627 5116 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 551 7 4 4 5.6 COc1ccccc1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
134144355 150580 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1774 47 17 22 -0.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)C(Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
CHEMBL3954412 150580 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1774 47 17 22 -0.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)C(Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
134137019 142760 None 0 Rat Binding pIC50 = 8 8.0 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1518 41 18 22 -4.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c(O)c1)C(C)C)C(N)=O nan
CHEMBL3891981 142760 None 0 Rat Binding pIC50 = 8 8.0 - 0
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1518 41 18 22 -4.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c(O)c1)C(C)C)C(N)=O nan
44250209 198943 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 426 1 2 3 6.8 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563374 198943 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 426 1 2 3 6.8 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44301562 201956 None 0 Human Binding pKi = 6.0 6.0 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 494 10 4 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL59187 201956 None 0 Human Binding pKi = 6.0 6.0 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 494 10 4 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
44322391 107116 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 502 9 4 2 6.8 CC(C)c1cccc(C(C)C)c1NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL315660 107116 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 502 9 4 2 6.8 CC(C)c1cccc(C(C)C)c1NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
21255272 209085 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 4 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL89153 209085 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 4 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
57402754 67779 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 550 8 4 2 7.7 CC(C)c1cccc(C(C)C)c1NC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCc2ccccc21 10.1016/0960-894X(96)00481-7
CHEMBL1907865 67779 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 550 8 4 2 7.7 CC(C)c1cccc(C(C)C)c1NC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCc2ccccc21 10.1016/0960-894X(96)00481-7
101835328 704 None 34 Human Binding pKi = 8.7 8.7 -7 5
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
16133800 704 None 34 Human Binding pKi = 8.7 8.7 -7 5
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
16201612 704 None 34 Human Binding pKi = 8.7 8.7 -7 5
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
616 704 None 34 Human Binding pKi = 8.7 8.7 -7 5
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
91898967 704 None 34 Human Binding pKi = 8.7 8.7 -7 5
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
CHEMBL437027 704 None 34 Human Binding pKi = 8.7 8.7 -7 5
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
DB11724 704 None 34 Human Binding pKi = 8.7 8.7 -7 5
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
CHEMBL269432 213247 None 0 Human Binding pKi = 8.7 8.7 -2 2
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None CC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)O)C(C)C 10.1016/0960-894X(96)00481-7
44322247 208931 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 3 2 6.9 CC(C)c1cccc(C(C)C)c1N(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL88174 208931 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 3 2 6.9 CC(C)c1cccc(C(C)C)c1N(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
10432902 100677 None 0 Human Binding pKi = 5.6 5.6 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 431 9 4 4 3.1 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
CHEMBL291924 100677 None 0 Human Binding pKi = 5.6 5.6 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 431 9 4 4 3.1 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
44301871 100802 None 3 Human Binding pKi = 5.6 5.6 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 441 9 3 3 4.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL292766 100802 None 3 Human Binding pKi = 5.6 5.6 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 441 9 3 3 4.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
44301546 100678 None 0 Human Binding pKi = 5.6 5.6 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 431 9 4 4 3.1 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
CHEMBL291925 100678 None 0 Human Binding pKi = 5.6 5.6 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 431 9 4 4 3.1 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
44301784 203313 None 0 Human Binding pKi = 5.6 5.6 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 460 10 4 3 4.7 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL60125 203313 None 0 Human Binding pKi = 5.6 5.6 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 460 10 4 3 4.7 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
40875375 202505 None 0 Human Binding pKi = 5.6 5.6 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 480 9 4 3 4.8 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL59561 202505 None 0 Human Binding pKi = 5.6 5.6 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 480 9 4 3 4.8 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
21255275 208762 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 502 8 4 2 7.0 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL87090 208762 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 502 8 4 2 7.0 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCCC1 10.1016/0960-894X(96)00481-7
44322304 209169 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 550 8 4 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCc2ccccc2C1 10.1016/0960-894X(96)00481-7
CHEMBL89795 209169 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 550 8 4 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCc2ccccc2C1 10.1016/0960-894X(96)00481-7
44301769 201778 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 446 9 4 3 4.3 CC(C)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL59055 201778 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 446 9 4 3 4.3 CC(C)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
10484081 100696 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 625 12 3 5 6.8 CC(C)CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1 10.1016/S0960-894X(97)00346-6
CHEMBL292119 100696 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 625 12 3 5 6.8 CC(C)CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1 10.1016/S0960-894X(97)00346-6
44322245 106040 None 0 Human Binding pKi = 5.4 5.4 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 434 7 4 2 5.3 CNC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)Nc1c(C(C)C)cccc1C(C)C 10.1016/0960-894X(96)00481-7
CHEMBL313114 106040 None 0 Human Binding pKi = 5.4 5.4 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 434 7 4 2 5.3 CNC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)Nc1c(C(C)C)cccc1C(C)C 10.1016/0960-894X(96)00481-7
44301371 101015 None 0 Human Binding pKi = 5.4 5.4 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 470 9 5 4 3.6 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
CHEMBL294165 101015 None 0 Human Binding pKi = 5.4 5.4 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 470 9 5 4 3.6 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
44301825 100870 None 0 Human Binding pKi = 5.4 5.4 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 397 9 4 4 2.9 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
CHEMBL293240 100870 None 0 Human Binding pKi = 5.4 5.4 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 397 9 4 4 2.9 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
10000877 101662 None 0 Human Binding pKi = 5.4 5.4 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 397 9 4 4 2.9 CC(C)CCNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
CHEMBL298816 101662 None 0 Human Binding pKi = 5.4 5.4 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 397 9 4 4 2.9 CC(C)CCNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
44322461 155959 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 610 9 4 4 7.5 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1COC(C)(C)OC1c1ccccc1 10.1016/0960-894X(96)00481-7
CHEMBL406037 155959 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 610 9 4 4 7.5 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1COC(C)(C)OC1c1ccccc1 10.1016/0960-894X(96)00481-7
44301870 205147 None 0 Human Binding pKi = 5.4 5.4 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 407 9 3 3 3.8 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL61615 205147 None 0 Human Binding pKi = 5.4 5.4 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 407 9 3 3 3.8 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00346-6
44322341 105993 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 4 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C)C1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL312851 105993 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 4 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C)C1CCCCC1 10.1016/0960-894X(96)00481-7
44322126 106247 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 524 10 4 2 6.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1016/0960-894X(96)00481-7
CHEMBL313829 106247 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 524 10 4 2 6.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1016/0960-894X(96)00481-7
44302017 201787 None 0 Human Binding pKi = 5.3 5.3 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 446 9 4 3 4.3 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL59060 201787 None 0 Human Binding pKi = 5.3 5.3 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 446 9 4 3 4.3 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
21255273 111652 None 0 Human Binding pKi = 6.3 6.3 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 3 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)CC1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL328230 111652 None 0 Human Binding pKi = 6.3 6.3 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 3 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)CC1CCCCC1 10.1016/0960-894X(96)00481-7
44301554 204886 None 0 Human Binding pKi = 5.3 5.3 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 484 10 5 4 3.6 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]cn1)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL61098 204886 None 0 Human Binding pKi = 5.3 5.3 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 484 10 5 4 3.6 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]cn1)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
5311352 3033 None 9 Human Binding pKi = 8.2 8.2 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
620 3033 None 9 Human Binding pKi = 8.2 8.2 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
CHEMBL86828 3033 None 9 Human Binding pKi = 8.2 8.2 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
5311352 3033 None 9 Human Binding pKi = 8.2 8.2 - 1
Binding affinity against human NMB receptor was determinedBinding affinity against human NMB receptor was determined
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
620 3033 None 9 Human Binding pKi = 8.2 8.2 - 1
Binding affinity against human NMB receptor was determinedBinding affinity against human NMB receptor was determined
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
CHEMBL86828 3033 None 9 Human Binding pKi = 8.2 8.2 - 1
Binding affinity against human NMB receptor was determinedBinding affinity against human NMB receptor was determined
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
40652201 201547 None 0 Human Binding pKi = 5.2 5.2 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 407 9 3 3 4.2 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL58852 201547 None 0 Human Binding pKi = 5.2 5.2 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 407 9 3 3 4.2 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
44322460 209607 None 0 Human Binding pKi = 6.2 6.2 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 534 8 4 4 5.8 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1COC(C)(C)OC1 10.1016/0960-894X(96)00481-7
CHEMBL92274 209607 None 0 Human Binding pKi = 6.2 6.2 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 534 8 4 4 5.8 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1COC(C)(C)OC1 10.1016/0960-894X(96)00481-7
44322303 112441 None 0 Human Binding pKi = 8.1 8.1 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 592 10 4 2 8.6 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL329561 112441 None 0 Human Binding pKi = 8.1 8.1 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 592 10 4 2 8.6 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CCCCC1 10.1016/0960-894X(96)00481-7
21255282 107141 None 0 Human Binding pKi = 7.1 7.1 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 550 8 4 2 7.7 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCc2ccccc21 10.1016/0960-894X(96)00481-7
CHEMBL315859 107141 None 0 Human Binding pKi = 7.1 7.1 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 550 8 4 2 7.7 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCc2ccccc21 10.1016/0960-894X(96)00481-7
57391433 67713 None 0 Human Binding pKi = 7.1 7.1 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 578 9 4 2 8.4 CC(C)c1cccc(C(C)C)c1NC(=O)N[C@@](C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCCC1c1ccccc1 10.1016/0960-894X(96)00481-7
CHEMBL1907682 67713 None 0 Human Binding pKi = 7.1 7.1 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 578 9 4 2 8.4 CC(C)c1cccc(C(C)C)c1NC(=O)N[C@@](C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCCC1c1ccccc1 10.1016/0960-894X(96)00481-7
21255267 111712 None 0 Human Binding pKi = 6.1 6.1 1 2
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 3 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)N(C)C(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL328591 111712 None 0 Human Binding pKi = 6.1 6.1 1 2
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 3 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)N(C)C(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
44301939 203401 None 0 Human Binding pKi = 5.1 5.1 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 475 12 5 4 3.8 NCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL60176 203401 None 0 Human Binding pKi = 5.1 5.1 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 475 12 5 4 3.8 NCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL525577 218143 None 0 Human Binding pKi = 8.1 8.1 -24 3
Binding affinity to neuromedin B receptorBinding affinity to neuromedin B receptor
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O 10.1016/j.bmcl.2008.09.033
44301811 102058 None 0 Human Binding pKi = 5.1 5.1 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 461 11 5 4 3.4 NCCCCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL301636 102058 None 0 Human Binding pKi = 5.1 5.1 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 461 11 5 4 3.4 NCCCCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
44322273 209076 None 0 Human Binding pKi = 7.0 7.0 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 610 9 4 4 7.5 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H]1COC(C)(C)OC1c1ccccc1 10.1016/0960-894X(96)00481-7
CHEMBL89075 209076 None 0 Human Binding pKi = 7.0 7.0 - 1
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 610 9 4 4 7.5 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H]1COC(C)(C)OC1c1ccccc1 10.1016/0960-894X(96)00481-7
44301807 163303 None 0 Human Binding pKi = 6.0 6.0 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 533 10 5 3 5.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL418299 163303 None 0 Human Binding pKi = 6.0 6.0 - 1
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 533 10 5 3 5.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
5311352 3033 None 9 Human Binding pKd = 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C None
620 3033 None 9 Human Binding pKd = 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C None
CHEMBL86828 3033 None 9 Human Binding pKd = 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C None
5281668 2202 None 0 Rat Binding pKi = 5.2 5.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 760 9 8 11 8.8 CC(=CCc1c(O)ccc(c1O)C(=O)[C@H]1[C@@H](CC(=C[C@@H]1c1c(O)cc(c2c1oc(c1ccc(cc1O)O)c(c2=O)CC=C(C)C)O)C)c1ccc(cc1O)O)C 7646517
622 2202 None 0 Rat Binding pKi = 5.2 5.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 760 9 8 11 8.8 CC(=CCc1c(O)ccc(c1O)C(=O)[C@H]1[C@@H](CC(=C[C@@H]1c1c(O)cc(c2c1oc(c1ccc(cc1O)O)c(c2=O)CC=C(C)C)O)C)c1ccc(cc1O)O)C 7646517
CHEMBL506234 2202 None 0 Rat Binding pKi = 5.2 5.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 760 9 8 11 8.8 CC(=CCc1c(O)ccc(c1O)C(=O)[C@H]1[C@@H](CC(=C[C@@H]1c1c(O)cc(c2c1oc(c1ccc(cc1O)O)c(c2=O)CC=C(C)C)O)C)c1ccc(cc1O)O)C 7646517
155817488 3327 None 0 Rat Binding pKi = 6.3 6.3 -14 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
155817488 3327 None 0 Rat Binding pKi = 6.3 6.3 -14 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
57340152 3327 None 0 Rat Binding pKi = 6.3 6.3 -14 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
57340152 3327 None 0 Rat Binding pKi = 6.3 6.3 -14 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
6165 3327 None 0 Rat Binding pKi = 6.3 6.3 -14 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
6165 3327 None 0 Rat Binding pKi = 6.3 6.3 -14 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
612 1776 None 0 Rat Binding pKi = 6.4 6.4 -288 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
612 1776 None 0 Rat Binding pKi = 6.4 6.4 -288 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
612 1776 None 0 Rat Binding pKi = 6.4 6.4 -288 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
612 1776 None 0 Rat Binding pKi = 6.4 6.4 -288 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
CHEMBL413196 1776 None 0 Rat Binding pKi = 6.4 6.4 -288 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
CHEMBL413196 1776 None 0 Rat Binding pKi = 6.4 6.4 -288 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
CHEMBL413196 1776 None 0 Rat Binding pKi = 6.4 6.4 -288 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
CHEMBL413196 1776 None 0 Rat Binding pKi = 6.4 6.4 -288 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
635 1450 None 0 Rat Binding pKi = 6.9 6.9 1 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
155817489 3115 None 0 Rat Binding pKi = 7.3 7.3 5 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
155817489 3115 None 0 Rat Binding pKi = 7.3 7.3 5 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
6166 3115 None 0 Rat Binding pKi = 7.3 7.3 5 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
6166 3115 None 0 Rat Binding pKi = 7.3 7.3 5 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
615 3102 None 0 Rat Binding pKi = 7.3 7.3 -58 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
615 3102 None 0 Rat Binding pKi = 7.3 7.3 -58 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
615 3102 None 0 Rat Binding pKi = 7.3 7.3 -58 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
101835328 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
101835328 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
16133800 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
16133800 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
16201612 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
16201612 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
616 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
616 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
91898967 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
91898967 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
CHEMBL437027 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
CHEMBL437027 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
DB11724 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
DB11724 704 None 34 Human Binding pKi = 7.5 7.5 -7 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
101835328 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
101835328 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
16133800 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
16133800 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
16201612 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
16201612 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
616 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
616 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
91898967 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
91898967 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
CHEMBL437027 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
CHEMBL437027 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
DB11724 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
DB11724 704 None 34 Rat Binding pKi = 7.6 7.6 -24 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
22146595 3290 None 0 Rat Binding pKi = 7.9 7.9 -6 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
22146595 3290 None 0 Rat Binding pKi = 7.9 7.9 -6 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
618 3290 None 0 Rat Binding pKi = 7.9 7.9 -6 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
618 3290 None 0 Rat Binding pKi = 7.9 7.9 -6 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
14235547 2329 None 0 Rat Binding pKi = 8.2 8.2 -1 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
14235547 2329 None 0 Rat Binding pKi = 8.2 8.2 -1 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
617 2329 None 0 Rat Binding pKi = 8.2 8.2 -1 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
617 2329 None 0 Rat Binding pKi = 8.2 8.2 -1 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
632 1478 None 0 Human Binding pKi = 8.8 8.8 -1 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
632 1478 None 0 Human Binding pKi = 8.8 8.8 -1 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
4345957 2768 None 0 Human Binding pKi = 9.2 9.2 89 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18055507
4345957 2768 None 0 Human Binding pKi = 9.2 9.2 89 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
4345957 2768 None 0 Human Binding pKi = 9.2 9.2 89 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 25976083
613 2768 None 0 Human Binding pKi = 9.2 9.2 89 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18055507
613 2768 None 0 Human Binding pKi = 9.2 9.2 89 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
613 2768 None 0 Human Binding pKi = 9.2 9.2 89 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 25976083
155817490 2307 None 0 Rat Binding pKi > 5 5.0 -23 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
155817490 2307 None 0 Rat Binding pKi > 5 5.0 -23 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
6168 2307 None 0 Rat Binding pKi > 5 5.0 -23 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
6168 2307 None 0 Rat Binding pKi > 5 5.0 -23 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344