GPCRdb

Ligand source activities (1 row/activity)

ChEMBL ID	Receptor	Species	Purchasable	p-value (-log)	Activity Type	Activity Relation	Activity Value	Unit	Assay Type	Assay Description	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles

CHEMBL7753	fpr1_human	Human	No	9.0	EC50	=	1	nM	Funct	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils	558	15	5	6	3.3	COc1ccc(NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)O)cc1
CHEMBL267388	fpr1_human	Human	No	9.0	EC50	=	1	nM	Funct	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils		None	None	None		CSCC[C@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL267179	fpr1_human	Human	Yes	8.0	EC50	=	10	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay		None	None	None		None
CHEMBL4793814	fpr1_human	Human	No	7.0	EC50	=	100	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	359	4	3	3	2.8	COc1ccc([C@@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1
CHEMBL4789579	fpr1_human	Human	No	6.0	EC50	=	1000	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	391	5	3	4	2.4	COc1ccc(NC(=O)N[C@@H]2C(=O)NC[C@H]2c2c(F)cc(OC)cc2F)cc1
CHEMBL4790836	fpr1_human	Human	No	6.0	EC50	=	1000	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	391	4	4	4	2.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1
CHEMBL4549250	fpr1_human	Human	No	5.0	EC50	=	10000	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	427	7	1	6	3.5	COc1ccc(OC)c(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1
CHEMBL4166385	fpr1_human	Human	No	5.0	EC50	=	10300	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	500	9	3	4	4.6	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1
CHEMBL2391281	fpr1_human	Human	No	5.0	EC50	=	10500	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	445	5	1	4	4.2	Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1
CHEMBL562456	fpr1_human	Human	No	5.0	EC50	=	10500	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	408	7	1	7	2.7	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc([N+](=O)[O-])cc3)c2=O)c1
CHEMBL2391257	fpr1_human	Human	No	5.0	EC50	=	10800	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	509	7	1	5	5.3	COc1cccc(Cc2cc(C3CCCCC3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL562910	fpr1_human	Human	No	6.0	EC50	=	1100	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1
CHEMBL562910	fpr1_human	Human	No	6.0	EC50	=	1100	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1
CHEMBL2391452	fpr1_human	Human	No	5.0	EC50	=	11200	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	427	5	1	5	3.6	COc1ccc(-c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1
CHEMBL551590	fpr1_human	Human	No	5.0	EC50	=	11300	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL551590	fpr1_human	Human	No	5.0	EC50	=	11300	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL4448213	fpr1_human	Human	No	4.9	EC50	=	11481.5	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	497	9	1	5	5.3	CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O
CHEMBL4758920	fpr1_human	Human	No	6.9	EC50	=	120	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	395	4	3	3	3.0	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
CHEMBL4760897	fpr1_human	Human	No	5.9	EC50	=	1200	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	401	4	3	4	3.1	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1
CHEMBL4536766	fpr1_human	Human	No	5.9	EC50	=	1230.3	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	397	6	1	5	3.4	COc1ccccc1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O
CHEMBL4551649	fpr1_human	Human	No	6.9	EC50	=	125.9	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O
CHEMBL2391449	fpr1_human	Human	No	4.9	EC50	=	12800	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	442	6	2	6	3.7	COc1ccc(Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1
CHEMBL2391447	fpr1_human	Human	No	4.9	EC50	=	13500	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	484	7	2	7	3.9	COc1ccc(Nc2c(C(C)=O)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1
CHEMBL4442702	fpr1_human	Human	No	5.9	EC50	=	1380.4	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	411	6	1	5	4.0	COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Cl)cc2)c1=O
CHEMBL2391438	fpr1_human	Human	No	4.9	EC50	=	13800	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	461	5	1	4	4.7	Cc1cc(Cc2cccc3ccccc23)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1
CHEMBL4447830	fpr1_human	Human	No	6.8	EC50	=	144.5	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	441	7	1	6	4.0	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1OC
CHEMBL4448213	fpr1_human	Human	No	6.8	EC50	=	147.9	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	497	9	1	5	5.3	CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O
CHEMBL4783963	fpr1_human	Human	No	5.8	EC50	=	1500	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	377	4	3	2	3.1	CCc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1
CHEMBL4172556	fpr1_human	Human	No	5.8	EC50	=	1500	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1
CHEMBL4447830	fpr1_human	Human	No	6.8	EC50	=	154.9	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	441	7	1	6	4.0	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1OC
CHEMBL554291	fpr1_human	Human	No	4.8	EC50	=	15500	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1
CHEMBL1770476	fpr1_human	Human	No	5.8	EC50	=	1584.9	nM	Funct	Agonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assayAgonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay	424	8	2	6	4.6	CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1
CHEMBL539401	fpr1_human	Human	No	5.8	EC50	=	1600	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1
CHEMBL539401	fpr1_human	Human	No	5.8	EC50	=	1600	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1
CHEMBL4447632	fpr1_human	Human	No	6.8	EC50	=	169.8	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	427	7	1	6	3.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1OC
CHEMBL4744835	fpr1_human	Human	No	7.8	EC50	=	17	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F
CHEMBL4763824	fpr1_human	Human	No	5.8	EC50	=	1700	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cccc(F)c2)c(F)c1
CHEMBL4442702	fpr1_human	Human	No	4.8	EC50	=	17378.0	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	411	6	1	5	4.0	COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Cl)cc2)c1=O
CHEMBL4448576	fpr1_human	Human	No	5.8	EC50	=	1778.3	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	443	5	1	4	4.2	Cc1cc(Cc2ccccc2F)c(=O)n(C(C)C(=O)Nc2ccc(Br)cc2)n1
CHEMBL4436651	fpr1_human	Human	No	5.7	EC50	=	1819.7	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	443	5	1	4	4.2	Cc1cc(Cc2ccc(F)cc2)c(=O)n(C(C)C(=O)Nc2ccc(Br)cc2)n1
CHEMBL4517103	fpr1_human	Human	No	5.7	EC50	=	1862.1	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	425	7	1	5	4.4	CCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O
CHEMBL4166447	fpr1_human	Human	No	4.7	EC50	=	18800	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	470	8	4	2	4.9	O=C(Nc1ccc(F)cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1
CHEMBL4753713	fpr1_human	Human	No	6.7	EC50	=	190	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	362	4	3	4	1.8	COc1cnc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1
CHEMBL4781488	fpr1_human	Human	No	5.7	EC50	=	1900	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	378	4	4	3	2.5	CNc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1
CHEMBL266802	fpr1_human	Human	No	8.7	EC50	=	2	nM	Funct	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils		None	None	None		CSCC[C@H](NC(=O)Nc1ccc(C)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL267179	fpr1_human	Human	Yes	7.7	EC50	=	20	nM	Funct	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils		None	None	None		None
CHEMBL4543016	fpr1_human	Human	No	5.7	EC50	=	2089.3	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	443	5	1	4	4.2	Cc1cc(Cc2cccc(F)c2)c(=O)n(C(C)C(=O)Nc2ccc(Br)cc2)n1
CHEMBL549570	fpr1_human	Human	No	4.7	EC50	=	21700	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1
CHEMBL549570	fpr1_human	Human	No	4.7	EC50	=	21700	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1
CHEMBL4447632	fpr1_human	Human	No	6.7	EC50	=	223.9	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	427	7	1	6	3.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1OC
CHEMBL556625	fpr1_human	Human	No	5.7	EC50	=	2238.7	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1
CHEMBL556485	fpr1_human	Human	No	5.6	EC50	=	2300	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1
CHEMBL4176353	fpr1_human	Human	No	5.6	EC50	=	2400	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	452	8	4	2	4.7	O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1
CHEMBL4532583	fpr1_human	Human	Yes	6.6	EC50	=	245.5	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	527	10	1	6	5.3	CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O
CHEMBL4588649	fpr1_human	Human	No	4.6	EC50	=	25118.9	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	411	6	1	5	4.0	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1
CHEMBL3588871	fpr1_human	Human	No	6.6	EC50	=	260	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1
CHEMBL556625	fpr1_human	Human	No	5.6	EC50	=	2600	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1
CHEMBL551589	fpr1_human	Human	No	5.6	EC50	=	2600	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL551589	fpr1_human	Human	No	5.6	EC50	=	2600	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL4440569	fpr1_human	Human	No	5.6	EC50	=	2630.3	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	455	6	1	5	4.1	COc1ccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)cc1
CHEMBL4476616	fpr1_human	Human	No	5.6	EC50	=	2630.3	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	427	7	1	6	3.5	COc1cccc(OC)c1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O
CHEMBL4781596	fpr1_human	Human	Yes	6.6	EC50	=	280	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1
CHEMBL560780	fpr1_human	Human	No	5.6	EC50	=	2800	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1
CHEMBL4784510	fpr1_human	Human	Yes	5.6	EC50	=	2800	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1
CHEMBL4172968	fpr1_human	Human	No	5.6	EC50	=	2800	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	483	9	3	5	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1
CHEMBL4476616	fpr1_human	Human	No	5.6	EC50	=	2818.4	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	427	7	1	6	3.5	COc1cccc(OC)c1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O
CHEMBL4440250	fpr1_human	Human	No	5.6	EC50	=	2818.4	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	439	7	1	5	4.6	COc1ccccc1Cc1cc(C)nn(C(C(=O)Nc2ccc(Cl)cc2)C(C)C)c1=O
CHEMBL4793557	fpr1_human	Human	No	7.5	EC50	=	29	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	365	3	3	2	3.0	O=C(Nc1ccc(F)cc1)N[C@@H]1C(=O)NC[C@H]1c1ccc(Cl)cc1F
CHEMBL4778725	fpr1_human	Human	No	6.5	EC50	=	290	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	382	4	3	5	2.1	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc(C)ns2)c(F)c1
CHEMBL2391440	fpr1_human	Human	No	4.5	EC50	=	29300	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	454	6	2	5	2.6	Cc1cc(Cc2ccc(C(N)=O)cc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1
CHEMBL4744094	fpr1_human	Human	No	8.4	EC50	=	3.9	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	359	4	3	3	2.8	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1
CHEMBL265408	fpr1_human	Human	No	6.5	EC50	=	300	nM	Funct	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils		None	None	None		CCCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL2391446	fpr1_human	Human	No	5.5	EC50	=	3000	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	455	6	1	6	3.2	COc1cccc(C(=O)c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL4749577	fpr1_human	Human	No	5.5	EC50	=	3000	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	417	4	3	4	3.6	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc3ccccc3s2)c(F)c1
CHEMBL7306	fpr1_human	Human	No	5.5	EC50	=	3000	nM	Funct	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils		None	None	None		CSCC[C@H](NC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL4744094	fpr1_human	Human	No	7.5	EC50	=	31	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	359	4	3	3	2.8	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1
CHEMBL379761	fpr1_human	Human	Yes	7.5	EC50	=	32.4	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl
CHEMBL564392	fpr1_human	Human	Yes	5.5	EC50	=	3200	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL560780	fpr1_human	Human	No	5.5	EC50	=	3200	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1
CHEMBL561375	fpr1_human	Human	No	5.5	EC50	=	3200	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	363	6	1	5	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1
CHEMBL560780	fpr1_human	Human	No	5.5	EC50	=	3200	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1
CHEMBL561375	fpr1_human	Human	No	5.5	EC50	=	3200	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	363	6	1	5	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1
CHEMBL4763673	fpr1_human	Human	No	5.5	EC50	=	3200	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	375	4	3	3	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)cc2)c(F)c1
CHEMBL4581644	fpr1_human	Human	Yes	6.5	EC50	=	331.1	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	497	9	1	5	5.3	CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O
CHEMBL4588649	fpr1_human	Human	No	5.5	EC50	=	3388.4	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	411	6	1	5	4.0	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1
CHEMBL551589	fpr1_human	Human	No	5.5	EC50	=	3400	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL4742149	fpr1_human	Human	No	6.5	EC50	=	350	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	386	4	3	4	2.2	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C#N)cc2)c(F)c1
CHEMBL554291	fpr1_human	Human	No	5.4	EC50	=	3600	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1
CHEMBL556485	fpr1_human	Human	No	5.4	EC50	=	3600	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1
CHEMBL554291	fpr1_human	Human	No	5.4	EC50	=	3600	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1
CHEMBL556485	fpr1_human	Human	No	5.4	EC50	=	3600	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1
CHEMBL552396	fpr1_human	Human	No	5.4	EC50	=	3900	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1
CHEMBL552396	fpr1_human	Human	No	5.4	EC50	=	3900	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1
CHEMBL4776349	fpr1_human	Human	No	7.4	EC50	=	40	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	411	4	4	4	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)c(O)c2)c(F)c1
CHEMBL7520	fpr1_human	Human	No	7.4	EC50	=	40	nM	Funct	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils		None	None	None		CSCC[C@H](NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL4784510	fpr1_human	Human	Yes	6.4	EC50	=	400	nM	Funct	Agonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1
CHEMBL4758129	fpr1_human	Human	No	4.4	EC50	=	40000	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	374	3	3	3	2.4	N#Cc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1
CHEMBL4743133	fpr1_human	Human	No	6.4	EC50	=	410	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	377	4	3	3	2.9	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(Cl)c1
CHEMBL2391255	fpr1_human	Human	No	5.4	EC50	=	4200	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	503	7	1	5	3.6	CCc1cc(Cc2cccc(OC)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1
CHEMBL3588871	fpr1_human	Human	No	6.4	EC50	=	430	nM	Funct	Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1
CHEMBL562380	fpr1_human	Human	No	5.4	EC50	=	4300	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1
CHEMBL562380	fpr1_human	Human	No	5.4	EC50	=	4300	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1
CHEMBL4159569	fpr1_human	Human	No	6.4	EC50	=	450	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1
CHEMBL2391256	fpr1_human	Human	No	5.4	EC50	=	4500	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	469	7	1	5	4.4	COc1cccc(Cc2cc(C(C)C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL2391286	fpr1_human	Human	No	5.4	EC50	=	4500	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	417	5	1	5	3.6	Cc1cc(Cc2ccsc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1
CHEMBL4162303	fpr1_human	Human	No	5.3	EC50	=	4700	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	483	9	3	5	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1
CHEMBL552527	fpr1_human	Human	Yes	6.3	EC50	=	500	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay		None	None	None		CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](CCSC)C(N)=O)C(C)C
CHEMBL4784510	fpr1_mouse	Mouse	Yes	6.3	EC50	=	500	nM	Funct	Agonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1
CHEMBL4539397	fpr1_human	Human	No	5.3	EC50	=	5011.9	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	391	7	1	5	3.4	CCc1ccc(NC(=O)Cn2nc(C)cc(Cc3ccccc3OC)c2=O)cc1
CHEMBL379761	fpr1_human	Human	Yes	7.3	EC50	=	51.3	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl
CHEMBL4162930	fpr1_human	Human	No	5.3	EC50	=	5200	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	508	8	3	3	5.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1
CHEMBL4551649	fpr1_human	Human	No	5.3	EC50	=	5248.1	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O
CHEMBL4536334	fpr1_human	Human	No	7.3	EC50	=	55.0	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	483	10	1	6	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O
CHEMBL4173645	fpr1_human	Human	No	5.3	EC50	=	5400	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	508	8	3	3	5.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1
CHEMBL2391277	fpr1_human	Human	No	5.3	EC50	=	5500	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	411	5	1	4	3.5	Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1
CHEMBL4452950	fpr1_human	Human	No	5.3	EC50	=	5623.4	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	415	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3F)c2=O)c1
CHEMBL549570	fpr1_human	Human	No	5.2	EC50	=	5700	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1
CHEMBL2391285	fpr1_human	Human	No	5.2	EC50	=	5800	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	401	5	1	5	3.1	Cc1cc(Cc2ccoc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1
CHEMBL4169807	fpr1_human	Human	No	5.2	EC50	=	5900	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	488	8	3	3	4.7	Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F
CHEMBL4532583	fpr1_human	Human	Yes	8.2	EC50	=	6.5	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	527	10	1	6	5.3	CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O
CHEMBL551589	fpr1_human	Human	No	5.2	EC50	=	6025.6	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL4454594	fpr1_human	Human	Yes	6.2	EC50	=	603	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O
CHEMBL2391254	fpr1_human	Human	No	5.2	EC50	=	6100	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	427	6	1	5	3.2	COc1cccc(Cc2ccnn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL4170201	fpr1_human	Human	No	6.2	EC50	=	630	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1
CHEMBL4549250	fpr1_human	Human	No	5.2	EC50	=	6309.6	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	427	7	1	6	3.5	COc1ccc(OC)c(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1
CHEMBL4551842	fpr1_human	Human	No	5.2	EC50	=	6309.6	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	439	8	1	5	4.8	CCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O
CHEMBL2391280	fpr1_human	Human	No	5.2	EC50	=	6600	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	429	5	1	4	3.7	Cc1cc(Cc2cccc(F)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1
CHEMBL556625	fpr1_human	Human	No	5.2	EC50	=	6700	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1
CHEMBL556625	fpr1_human	Human	No	5.2	EC50	=	6700	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1
CHEMBL2391279	fpr1_human	Human	No	5.2	EC50	=	6900	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	377	5	1	6	2.5	Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc3c(c2)OCO3)n1
CHEMBL4792002	fpr1_human	Human	No	5.2	EC50	=	6900	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	396	4	3	4	2.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cn2)c(F)c1
CHEMBL4751168	fpr1_human	Human	No	7.1	EC50	=	72	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	361	4	3	3	2.4	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F
CHEMBL4755590	fpr1_human	Human	No	7.1	EC50	=	72	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	395	4	4	4	2.2	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(O)c2)c(F)c1
CHEMBL539401	fpr1_human	Human	No	5.1	EC50	=	7200	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1
CHEMBL4473444	fpr1_human	Human	No	5.1	EC50	=	7585.8	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	395	6	1	5	3.5	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3cccc(F)c3)c2=O)c1
CHEMBL4743084	fpr1_human	Human	No	7.1	EC50	=	76	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	357	4	3	3	2.5	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(C)c1
CHEMBL2391442	fpr1_human	Human	No	5.1	EC50	=	7600	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	519	7	1	6	3.4	COc1cc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)cc(OC)c1
CHEMBL552396	fpr1_human	Human	No	5.1	EC50	=	7600	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1
CHEMBL562910	fpr1_human	Human	No	5.1	EC50	=	7700	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1
CHEMBL4583846	fpr1_human	Human	No	5.1	EC50	=	7943.3	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3ccccc3OC)c2=O)cc1
CHEMBL564392	fpr1_human	Human	Yes	6.1	EC50	=	800	nM	Funct	Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL564392	fpr1_human	Human	Yes	6.1	EC50	=	800	nM	Funct	Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL4740375	fpr1_human	Human	No	7.1	EC50	=	81	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	359	4	3	3	2.8	COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1
CHEMBL2391437	fpr1_human	Human	No	5.1	EC50	=	8100	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	417	5	1	5	3.6	Cc1cc(Cc2cccs2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1
CHEMBL2391448	fpr1_human	Human	No	5.1	EC50	=	8100	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	336	3	2	5	1.5	Cc1cc(N)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1
CHEMBL4762030	fpr1_human	Human	No	6.1	EC50	=	820	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	397	4	3	3	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1
CHEMBL4454594	fpr1_human	Human	Yes	7.1	EC50	=	83	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O
CHEMBL4454594	fpr1_human	Human	Yes	7.1	EC50	=	83.2	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O
CHEMBL4164673	fpr1_human	Human	No	6.1	EC50	=	850	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1
CHEMBL4465768	fpr1_human	Human	No	6.1	EC50	=	851.1	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	455	6	1	5	4.1	COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Br)cc2)c1=O
CHEMBL4569975	fpr1_human	Human	No	5.1	EC50	=	8511.4	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	395	6	1	5	3.5	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(F)cc3)c2=O)c1
CHEMBL4745044	fpr1_human	Human	No	7.1	EC50	=	86	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	361	4	3	3	2.4	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1
CHEMBL4454594	fpr1_human	Human	Yes	6.1	EC50	=	891.3	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O
CHEMBL4743917	fpr1_human	Human	No	8.1	EC50	=	9	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	343	4	3	3	2.2	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1
CHEMBL6997	fpr1_human	Human	No	6.1	EC50	=	900	nM	Funct	Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils		None	None	None		CSCC[C@H](NC(=O)Nc1cccc(C)c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL2391258	fpr1_human	Human	No	5.1	EC50	=	9000	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	503	7	1	5	4.9	COc1cccc(Cc2cc(-c3ccccc3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL4793603	fpr1_human	Human	No	6.0	EC50	=	910	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	359	4	3	3	2.8	COc1ccc([C@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1
CHEMBL4536334	fpr1_human	Human	No	7.0	EC50	=	93.3	nM	Bind	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	483	10	1	6	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O
CHEMBL2391439	fpr1_human	Human	No	5.0	EC50	=	9300	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	412	5	1	5	2.9	Cc1cc(Cc2cccnc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1
CHEMBL2391450	fpr1_human	Human	No	5.0	EC50	=	9300	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	470	6	2	6	3.2	COc1cccc(C(=O)Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL4740375	fpr1_human	Human	No	6.0	EC50	=	950	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	359	4	3	3	2.8	COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1
CHEMBL4168567	fpr1_human	Human	No	6.0	EC50	=	950	nM	Funct	Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	482	9	4	3	4.8	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1
CHEMBL3590073	fpr1_human	Human	No	6.0	EC50	=	950	nM	Funct	Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1
CHEMBL2391443	fpr1_human	Human	No	5.0	EC50	=	9500	nM	Funct	Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	493	5	1	4	4.0	Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1
CHEMBL4761554	fpr1_human	Human	No	7.0	EC50	=	96	nM	Bind	Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	439	4	3	3	3.1	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Br)cc2)c(F)c1
CHEMBL551590	fpr1_human	Human	No	5.0	EC50	=	9700	nM	Funct	Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1
CHEMBL4551842	fpr1_human	Human	No	5.0	EC50	=	9772.4	nM	Funct	Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	439	8	1	5	4.8	CCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O
CHEMBL1628710	fpr1_human	Human	No	7.0	IC50	=	100	nM	Funct	Antagonist activity at FPR1Antagonist activity at FPR1		None	None	None		None
CHEMBL6450	fpr1_human	Human	No	7.0	IC50	=	100	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL6997	fpr1_human	Human	No	7.0	IC50	=	100	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CSCC[C@H](NC(=O)Nc1cccc(C)c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL1770298	fpr1_human	Human	No	7.0	IC50	=	100	nM	Bind	Displacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation countingDisplacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation counting	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O
CHEMBL1916276	fpr1_human	Human	No	6.0	IC50	=	1000	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	452	6	2	5	4.3	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)cnn2-c2ccccc2)cc1
CHEMBL1916286	fpr1_human	Human	No	6.0	IC50	=	1000	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	446	6	2	5	4.4	Cc1nn(-c2ccccc2)c(NS(=O)(=O)C2CCCCC2)c1C(=O)N[C@@H](C)C(C)(C)C
CHEMBL1916287	fpr1_human	Human	No	6.0	IC50	=	1000	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	459	6	2	6	3.7	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2cccnc2)c1C(=O)N[C@@H](C)C(C)(C)C
CHEMBL1934267	fpr1_human	Human	No	6.0	IC50	=	1000	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	420	6	2	5	4.0	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)C)cc1
CHEMBL1934423	fpr1_human	Human	No	6.0	IC50	=	1000	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	448	6	2	6	3.4	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOC2)cc1
CHEMBL268823	fpr1_human	Human	No	6.0	IC50	=	1000	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CSCC[C@H](NC(=O)NCC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7214	fpr1_human	Human	No	6.0	IC50	=	1000	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL1770476	fpr1_human	Human	No	6.0	IC50	=	1000	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	424	8	2	6	4.6	CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1
CHEMBL1770484	fpr1_human	Human	No	6.0	IC50	=	1000	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	391	7	2	4	5.3	CCC[C@H](NC(=O)c1oc2ccc(OCC)cc2c1C)c1nc2ccccc2[nH]1
CHEMBL832	fpr1_human	Human	Yes	5.0	IC50	=	10000	nM	Funct	Antagonist activity at FPR1Antagonist activity at FPR1	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1
CHEMBL1916086	fpr1_human	Human	No	5.0	IC50	=	10000	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	446	7	2	5	3.9	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccccc3)cnn2-c2ccccc2)cc1
CHEMBL1916257	fpr1_human	Human	No	5.0	IC50	=	10000	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	440	6	2	6	2.9	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)cnn2-c2ccccc2)cc1
CHEMBL1916263	fpr1_human	Human	No	5.0	IC50	=	10000	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	426	8	2	5	3.9	CCC(CC)NC(=O)c1cn(-c2ccccc2)nc1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1916264	fpr1_human	Human	No	5.0	IC50	=	10000	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	460	8	2	5	4.6	CCC(CC)NC(=O)c1cnn(-c2ccccc2Cl)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1916268	fpr1_human	Human	No	5.0	IC50	=	10000	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	392	8	2	5	3.5	CCC(CC)NC(=O)c1cnn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1934419	fpr1_human	Human	No	5.0	IC50	=	10000	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	510	6	2	7	3.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCS(=O)(=O)CC2)cc1
CHEMBL1770308	fpr1_human	Human	No	5.0	IC50	=	10000	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	388	5	2	3	4.5	Cc1cccc(C)c1NC(=O)C(c1ccccc1)N(C)C(=O)c1ccccc1O
CHEMBL1770469	fpr1_human	Human	Yes	5.0	IC50	=	10000	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	327	6	2	5	2.6	CSCCC(NC(=O)c1cnccn1)c1nc2ccccc2[nH]1
CHEMBL1770470	fpr1_human	Human	No	5.0	IC50	=	10000	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	330	6	2	5	3.1	CSCCC(NC(=O)c1ocnc1C)c1nc2ccccc2[nH]1
CHEMBL1770472	fpr1_human	Human	Yes	5.0	IC50	=	10000	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	339	6	2	3	4.1	CSCCC(NC(=O)c1ccc(C)cc1)c1nc2ccccc2[nH]1
CHEMBL1770482	fpr1_human	Human	No	5.0	IC50	=	10000	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	441	7	2	6	3.5	CCOc1ccc2oc(C(=O)NC(CS(C)(=O)=O)c3nc4ccccc4[nH]3)c(C)c2c1
CHEMBL4558185	fpr1_human	Human	No	6.0	IC50	=	1080	nM	Bind	Antagonist activity at human Gi/o-coupled FPR1 expressed in CHOK1 cells assessed as reduction in WKYMVm-NH2-induced beta-arrestin 2 recruitment incubated for 30 mins followed by WKYMVm-NH2 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gi/o-coupled FPR1 expressed in CHOK1 cells assessed as reduction in WKYMVm-NH2-induced beta-arrestin 2 recruitment incubated for 30 mins followed by WKYMVm-NH2 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay	560	6	1	6	5.4	CC[C@]12C=C(C(=O)OC)n3c(c(CCNC(=O)c4ccc(Br)cc4)c4ccccc43)[C@H]1N(C#N)CCC2
CHEMBL4444413	fpr1_human	Human	No	5.0	IC50	=	10900	nM	Funct	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
CHEMBL4463562	fpr1_human	Human	No	4.9	IC50	=	11700	nM	Funct	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	421	8	3	4	2.8	COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C
CHEMBL1916289	fpr1_human	Human	No	7.9	IC50	=	12.6	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	526	6	2	5	5.3	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c1C(=O)N[C@@H](C)C(C)(C)C
CHEMBL4538076	fpr1_human	Human	No	6.9	IC50	=	120	nM	Funct	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	475	9	3	4	4.1	COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
CHEMBL1916281	fpr1_human	Human	No	6.9	IC50	=	125.9	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1
CHEMBL1770153	fpr1_human	Human	Yes	5.9	IC50	=	1258.9	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	374	5	3	3	4.1	Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccccc1
CHEMBL4547265	fpr1_human	Human	No	4.9	IC50	=	12600	nM	Funct	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	465	8	3	5	3.5	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
CHEMBL3311300	fpr1_human	Human	No	6.9	IC50	=	140	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	893	22	6	8	6.6	CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL4455225	fpr1_human	Human	No	4.8	IC50	=	14500	nM	Funct	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	435	9	3	4	3.2	COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
CHEMBL2372498	fpr1_human	Human	No	5.8	IC50	=	1480	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		CC(C)C[C@@H]1NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@](O)(C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@H](O)[C@H](C)C/C=C/CO)N(C)C(=O)[C@H](C(C)C)N(C)C1=O
CHEMBL2021596	fpr1_human	Human	No	6.8	IC50	=	150	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells	1200	15	4	11	4.5	C/C=C/CC(C)C(C)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@H](C(C)C)C(=O)N1C
CHEMBL2369724	fpr1_human	Human	No	5.8	IC50	=	1570	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@H]([C@H](C)CC)C(=O)N1C
CHEMBL1770297	fpr1_human	Human	Yes	6.8	IC50	=	158.5	nM	Funct	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC
CHEMBL1916277	fpr1_human	Human	No	6.8	IC50	=	158.5	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	466	6	2	5	4.6	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)c(C)nn2-c2ccccc2)cc1
CHEMBL1916280	fpr1_human	Human	No	6.8	IC50	=	158.5	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	426	7	2	5	3.8	CCC(C)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1934426	fpr1_human	Human	No	6.8	IC50	=	158.5	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	488	7	2	6	4.4	Cc1nn(C2CCOCC2)c(NS(=O)(=O)c2ccc(C3CC3)cc2)c1C(=O)N[C@@H](C)C(C)(C)C
CHEMBL1770298	fpr1_human	Human	No	5.8	IC50	=	1584.9	nM	Funct	Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O
CHEMBL1916085	fpr1_human	Human	No	5.8	IC50	=	1584.9	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	452	6	1	5	4.4	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)cnn2-c2ccccc2)cc1
CHEMBL1916262	fpr1_human	Human	No	5.8	IC50	=	1584.9	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	426	8	2	5	3.9	CCC(CC)NC(=O)c1ncn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1934270	fpr1_human	Human	No	5.8	IC50	=	1584.9	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	434	5	2	5	4.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)(C)C)cc1
CHEMBL1770301	fpr1_human	Human	No	5.8	IC50	=	1584.9	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	378	5	3	5	2.9	Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1cn(C)cn1
CHEMBL1916265	fpr1_human	Human	No	4.8	IC50	=	15848.9	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	451	8	2	6	3.8	CCC(CC)NC(=O)c1cnn(-c2ccc(C#N)cc2)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL6997	fpr1_human	Human	No	5.8	IC50	=	1600	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		CSCC[C@H](NC(=O)Nc1cccc(C)c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL4465341	fpr1_human	Human	No	4.8	IC50	=	16500	nM	Funct	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	469	9	3	4	3.4	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
CHEMBL4547265	fpr1_human	Human	No	4.8	IC50	=	17100	nM	Funct	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	465	8	3	5	3.5	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
CHEMBL4556626	fpr1_human	Human	Yes	6.8	IC50	=	180	nM	Funct	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	469	9	3	4	3.4	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
CHEMBL2372478	fpr1_human	Human	No	5.8	IC50	=	1800	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL4543372	fpr1_human	Human	No	4.7	IC50	=	19600	nM	Funct	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	449	10	3	4	3.1	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C
CHEMBL1934413	fpr1_human	Human	No	6.7	IC50	=	199.5	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	432	6	2	5	4.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCC2)cc1
CHEMBL1916082	fpr1_human	Human	No	5.7	IC50	=	1995.3	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	426	8	2	5	3.9	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1916279	fpr1_human	Human	No	5.7	IC50	=	1995.3	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	440	6	2	5	4.1	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCC(C)(C)C)c(C)nn2-c2ccccc2)cc1
CHEMBL1770471	fpr1_human	Human	No	5.7	IC50	=	1995.3	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	365	6	2	4	4.5	CSCCC(NC(=O)c1sccc1Cl)c1nc2ccccc2[nH]1
CHEMBL1916266	fpr1_human	Human	No	4.7	IC50	=	19952.6	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	427	8	2	6	3.3	CCC(CC)NC(=O)c1cnn(-c2ccccn2)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL7753	fpr1_human	Human	No	8.7	IC50	=	2	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils	558	15	5	6	3.3	COc1ccc(NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)O)cc1
CHEMBL266802	fpr1_human	Human	No	8.7	IC50	=	2	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CSCC[C@H](NC(=O)Nc1ccc(C)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL267388	fpr1_human	Human	No	8.7	IC50	=	2	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CSCC[C@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7486	fpr1_human	Human	No	7.7	IC50	=	20	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		Cc1cccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1
CHEMBL267179	fpr1_human	Human	Yes	7.7	IC50	=	20	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		None
CHEMBL415296	fpr1_human	Human	No	7.7	IC50	=	20	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils	862	21	7	6	5.5	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7122	fpr1_human	Human	No	6.7	IC50	=	200	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7486	fpr1_human	Human	No	6.7	IC50	=	200	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		Cc1cccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1
CHEMBL3311030	fpr1_human	Human	Yes	5.7	IC50	=	2000	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL6779	fpr1_human	Human	No	5.7	IC50	=	2000	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	586	14	5	5	3.7	CSCC[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL415299	fpr1_human	Human	No	5.7	IC50	=	2000	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		CSCC[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7181	fpr1_human	Human	No	5.7	IC50	=	2000	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		CNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL266448	fpr1_human	Human	No	5.7	IC50	=	2000	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7034	fpr1_human	Human	No	5.7	IC50	=	2000	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CSCC[C@H](NC(=O)NC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7306	fpr1_human	Human	No	5.7	IC50	=	2000	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CSCC[C@H](NC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL2372474	fpr1_human	Human	No	5.7	IC50	=	2200	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL2372461	fpr1_human	Human	No	5.6	IC50	=	2300	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL4444320	fpr1_human	Human	No	5.6	IC50	=	2400	nM	Funct	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
CHEMBL4455225	fpr1_human	Human	No	4.6	IC50	=	24700	nM	Funct	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	435	9	3	4	3.2	COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
CHEMBL1916284	fpr1_human	Human	No	7.6	IC50	=	25.1	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	508	6	2	5	5.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C(F)(F)F)nn2-c2ccccc2)cc1
CHEMBL1916288	fpr1_human	Human	No	7.6	IC50	=	25.1	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	483	6	2	6	4.2	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C
CHEMBL1916288	fpr1_human	Human	No	7.6	IC50	=	25.1	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	483	6	2	6	4.2	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C
CHEMBL2372504	fpr1_human	Human	No	5.6	IC50	=	2500	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@](O)(C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL1770296	fpr1_human	Human	Yes	5.6	IC50	=	2511.9	nM	Funct	Antagonist activity at FPR1Antagonist activity at FPR1		None	None	None		CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL1934416	fpr1_human	Human	No	5.6	IC50	=	2511.9	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	450	8	2	6	3.7	COCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1545798	fpr1_human	Human	Yes	5.6	IC50	=	2511.9	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	331	6	2	3	4.1	CSCCC(NC(=O)C1CCCCC1)c1nc2ccccc2[nH]1
CHEMBL1770304	fpr1_human	Human	No	5.6	IC50	=	2511.9	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	386	5	3	3	4.0	O=C(NC(C(=O)NC1CCCCC1)c1ccc(Cl)cc1)c1ccccc1O
CHEMBL1770307	fpr1_human	Human	No	5.6	IC50	=	2511.9	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	460	5	3	4	4.3	Cc1cccc(C)c1NC(=O)C(NC(=O)c1nc2ccccc2[nH]c1=O)c1ccc(Cl)cc1
CHEMBL1770474	fpr1_human	Human	Yes	5.6	IC50	=	2511.9	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	415	8	1	4	5.3	CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccccc1
CHEMBL1934266	fpr1_human	Human	No	4.6	IC50	=	25118.9	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	406	8	2	5	3.8	CCC(CC)NC(=O)c1c(C)nn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1770298	fpr1_mouse	Mouse	No	4.6	IC50	=	25118.9	nM	Funct	Antagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assay	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O
CHEMBL2372477	fpr1_human	Human	No	5.6	IC50	=	2520	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C)C(=O)N1C
CHEMBL4463562	fpr1_human	Human	No	4.6	IC50	=	25300	nM	Funct	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	421	8	3	4	2.8	COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C
CHEMBL4543372	fpr1_human	Human	No	4.6	IC50	=	27700	nM	Funct	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	449	10	3	4	3.1	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C
CHEMBL1934424	fpr1_human	Human	No	8.4	IC50	=	4.0	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	490	7	2	6	4.6	CO[C@H]1CC[C@@H](n2nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c2NS(=O)(=O)c2ccc(C)cc2)CC1
CHEMBL7520	fpr1_human	Human	No	7.5	IC50	=	30	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CSCC[C@H](NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL415296	fpr1_human	Human	No	6.5	IC50	=	300	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils	862	21	7	6	5.5	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL265408	fpr1_human	Human	No	6.5	IC50	=	300	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CCCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL266089	fpr1_human	Human	No	6.5	IC50	=	300	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		C=C(C)NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7363	fpr1_human	Human	No	6.5	IC50	=	300	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CCCCNC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL2372488	fpr1_human	Human	No	6.5	IC50	=	300	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@](O)(C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL266448	fpr1_human	Human	No	5.5	IC50	=	3000	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		CCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7214	fpr1_human	Human	No	5.5	IC50	=	3000	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		CCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL415299	fpr1_human	Human	No	5.5	IC50	=	3000	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CSCC[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7181	fpr1_human	Human	No	5.5	IC50	=	3000	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL2372495	fpr1_human	Human	No	5.5	IC50	=	3000	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL1934415	fpr1_human	Human	No	7.5	IC50	=	31.6	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	460	6	2	5	5.0	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCCC2)cc1
CHEMBL1770297	fpr1_human	Human	Yes	7.5	IC50	=	31.6	nM	Bind	Displacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation countingDisplacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation counting	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC
CHEMBL4465341	fpr1_human	Human	No	4.5	IC50	=	31300	nM	Funct	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	469	9	3	4	3.4	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
CHEMBL1916255	fpr1_human	Human	No	6.5	IC50	=	316.2	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	440	9	2	5	4.3	CCCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1934417	fpr1_human	Human	No	6.5	IC50	=	316.2	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	464	9	2	6	4.1	COCCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1934422	fpr1_human	Human	No	6.5	IC50	=	316.2	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	462	6	2	6	3.8	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOCC2)cc1
CHEMBL1770298	fpr1_human	Human	No	6.5	IC50	=	316.2	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O
CHEMBL1770475	fpr1_human	Human	Yes	6.5	IC50	=	316.2	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	440	8	1	5	5.2	CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccc(C#N)cc1
CHEMBL1770297	fpr1_human	Human	Yes	5.5	IC50	=	3162.3	nM	Funct	Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC
CHEMBL1916275	fpr1_human	Human	No	5.5	IC50	=	3162.3	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	466	6	1	5	4.7	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)c(C)nn2-c2ccccc2)cc1
CHEMBL1934269	fpr1_human	Human	No	5.5	IC50	=	3162.3	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	460	6	2	5	4.0	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2CC(F)(F)F)cc1
CHEMBL1934421	fpr1_human	Human	No	5.5	IC50	=	3162.3	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	543	7	2	6	4.7	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCN(CC(F)(F)F)CC2)cc1
CHEMBL1770477	fpr1_human	Human	No	5.5	IC50	=	3162.3	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	424	8	2	6	4.6	CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncccc4[nH]3)c(C)c2c1
CHEMBL2372506	fpr1_human	Human	No	5.5	IC50	=	3250	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL4452346	fpr1_human	Human	No	5.5	IC50	=	3300	nM	Funct	Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	475	9	3	4	3.7	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1
CHEMBL2372456	fpr1_human	Human	No	5.5	IC50	=	3400	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CCC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](CCC)C(=O)N(C)[C@H](CC(C)C)C(=O)NC(C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL4444413	fpr1_human	Human	No	4.4	IC50	=	37400	nM	Funct	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
CHEMBL1934418	fpr1_human	Human	No	7.4	IC50	=	39.8	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	478	6	2	6	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCSCC2)cc1
CHEMBL1770298	fpr1_human	Human	No	6.4	IC50	=	398.1	nM	Funct	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O
CHEMBL1770298	fpr1_human	Human	No	6.4	IC50	=	398.1	nM	Funct	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O
CHEMBL1770298	fpr1_human	Human	No	6.4	IC50	=	398.1	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O
CHEMBL1934271	fpr1_human	Human	No	6.4	IC50	=	398.1	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	448	8	2	5	4.8	CCC(CC)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1916084	fpr1_human	Human	No	5.4	IC50	=	3981.1	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	438	6	2	5	4.0	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)cnn2-c2ccccc2)cc1
CHEMBL1916261	fpr1_human	Human	No	5.4	IC50	=	3981.1	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	427	8	2	6	3.3	CCC(CC)NC(=O)c1nnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1770309	fpr1_human	Human	Yes	5.4	IC50	=	3981.1	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	379	6	2	4	4.8	CSCCC(NC(=O)c1oc2ccccc2c1C)c1nc2ccccc2[nH]1
CHEMBL1770310	fpr1_human	Human	Yes	5.4	IC50	=	3981.1	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	329	6	2	4	3.7	CSCCC(NC(=O)c1occc1C)c1nc2ccccc2[nH]1
CHEMBL1770468	fpr1_human	Human	No	5.4	IC50	=	3981.1	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	341	6	3	4	3.5	CSCCC(NC(=O)c1ccccc1O)c1nc2ccccc2[nH]1
CHEMBL268823	fpr1_human	Human	No	5.4	IC50	=	4000	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		CSCC[C@H](NC(=O)NCC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311137	fpr1_human	Human	No	6.4	IC50	=	420	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	889	22	6	8	6.0	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL4556626	fpr1_human	Human	Yes	6.4	IC50	=	450	nM	Funct	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	469	9	3	4	3.4	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
CHEMBL162488	fpr1_human	Human	No	7.3	IC50	=	50	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)Nc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL162488	fpr1_human	Human	No	6.3	IC50	=	500	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)Nc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7122	fpr1_human	Human	No	6.3	IC50	=	500	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7034	fpr1_human	Human	No	5.3	IC50	=	5000	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		CSCC[C@H](NC(=O)NC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL1770297	fpr1_human	Human	Yes	6.3	IC50	=	501.2	nM	Funct	Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC
CHEMBL1770297	fpr1_human	Human	Yes	6.3	IC50	=	501.2	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC
CHEMBL1916272	fpr1_human	Human	No	6.3	IC50	=	501.2	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	440	8	2	5	4.2	CCC(CC)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1916283	fpr1_human	Human	No	6.3	IC50	=	501.2	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1
CHEMBL1770297	fpr1_human	Human	Yes	6.3	IC50	=	501.2	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC
CHEMBL1770295	fpr1_human	Human	Yes	5.3	IC50	=	5011.9	nM	Funct	Antagonist activity at FPR1Antagonist activity at FPR1	376	3	1	5	2.3	CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C
CHEMBL1916259	fpr1_human	Human	No	5.3	IC50	=	5011.9	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	412	8	2	5	3.6	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1
CHEMBL1916260	fpr1_human	Human	No	5.3	IC50	=	5011.9	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	404	8	2	5	3.5	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)C1CCCC1
CHEMBL1916267	fpr1_human	Human	No	5.3	IC50	=	5011.9	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	440	9	2	5	4.0	CCC(CC)NC(=O)c1cnn(Cc2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1916270	fpr1_human	Human	No	5.3	IC50	=	5011.9	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	479	9	2	7	4.2	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1
CHEMBL1916278	fpr1_human	Human	No	5.3	IC50	=	5011.9	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	454	6	2	6	3.2	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)c(C)nn2-c2ccccc2)cc1
CHEMBL1770303	fpr1_human	Human	No	5.3	IC50	=	5011.9	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	380	5	3	3	4.2	O=C(NC(C(=O)Nc1ccccc1)c1ccc(Cl)cc1)c1ccccc1O
CHEMBL1770466	fpr1_human	Human	Yes	5.3	IC50	=	5011.9	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	325	6	2	3	3.8	CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2[nH]1
CHEMBL1770478	fpr1_human	Human	No	5.3	IC50	=	5011.9	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	425	8	2	7	4.0	CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncncc4[nH]3)c(C)c2c1
CHEMBL4452346	fpr1_human	Human	No	6.3	IC50	=	540	nM	Funct	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	475	9	3	4	3.7	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1
CHEMBL2370883	fpr1_human	Human	No	5.3	IC50	=	5500	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)C1NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](C(C)C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H]([C@@H](C)O)NC1=O
CHEMBL2372486	fpr1_human	Human	No	6.3	IC50	=	560	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@](O)(C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL2372507	fpr1_human	Human	No	6.2	IC50	=	570	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@](O)(C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL4444320	fpr1_human	Human	No	5.2	IC50	=	5800	nM	Funct	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
CHEMBL2372505	fpr1_human	Human	No	6.2	IC50	=	590	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL7226	fpr1_human	Human	No	6.2	IC50	=	600	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		CSCC[C@H](NC(=O)NCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7363	fpr1_human	Human	No	6.2	IC50	=	600	nM	Funct	Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils		None	None	None		CCCCNC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL1770481	fpr1_human	Human	No	6.2	IC50	=	631.0	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	409	7	2	5	4.9	CCOc1ccc2oc(C(=O)N[C@H](CSC)c3nc4ccccc4[nH]3)c(C)c2c1
CHEMBL2372473	fpr1_human	Human	No	5.2	IC50	=	6300	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		CC/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](CCCCN)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL1916258	fpr1_human	Human	No	5.2	IC50	=	6309.6	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	426	8	2	5	3.9	CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1C
CHEMBL1916273	fpr1_human	Human	No	5.2	IC50	=	6309.6	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	412	6	2	5	3.4	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C)c(C)nn2-c2ccccc2)cc1
CHEMBL1934268	fpr1_human	Human	No	5.2	IC50	=	6309.6	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	406	6	2	5	3.5	CCn1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1
CHEMBL1770479	fpr1_human	Human	No	5.2	IC50	=	6309.6	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	391	7	2	4	5.0	CSCCC(NC(=O)c1sccc1Cl)c1ncc(-c2ccccc2)[nH]1
CHEMBL2372476	fpr1_human	Human	No	5.2	IC50	=	6330	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		CC[C@@H]1NC(=O)[C@H](CC2CCCCC2)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](C(C)C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)CN(C)C1=O
CHEMBL2370885	fpr1_human	Human	No	5.2	IC50	=	6450	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)C1NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](C(C)C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O
CHEMBL4538076	fpr1_human	Human	No	6.2	IC50	=	670	nM	Funct	Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry	475	9	3	4	4.1	COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
CHEMBL2372466	fpr1_human	Human	No	5.2	IC50	=	7000	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		CC/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL2372487	fpr1_human	Human	No	6.1	IC50	=	750	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@](O)(C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL1916271	fpr1_human	Human	No	7.1	IC50	=	79.4	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	519	8	1	7	5.1	CCN(C(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1)C1CCCCC1
CHEMBL1916282	fpr1_human	Human	No	7.1	IC50	=	79.4	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1
CHEMBL1916282	fpr1_human	Human	No	7.1	IC50	=	79.4	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1
CHEMBL1934414	fpr1_human	Human	No	7.1	IC50	=	79.4	nM	Funct	Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay	446	6	2	5	4.6	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCC2)cc1
CHEMBL1770300	fpr1_human	Human	No	7.1	IC50	=	79.4	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	402	5	3	3	4.7	Cc1cccc(C(NC(=O)c2ccccc2O)C(=O)Nc2c(C)cccc2C)c1C
CHEMBL1916087	fpr1_human	Human	No	6.1	IC50	=	794.3	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	474	7	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccc(C)cc3C)cnn2-c2ccccc2)cc1
CHEMBL1916274	fpr1_human	Human	No	6.1	IC50	=	794.3	nM	Funct	Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay	452	6	2	5	4.4	Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)c(C)nn2-c2ccccc2)cc1
CHEMBL1770299	fpr1_human	Human	Yes	6.1	IC50	=	794.3	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	408	5	3	3	4.8	Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccc(Cl)cc1
CHEMBL1770302	fpr1_human	Human	No	6.1	IC50	=	794.3	nM	Funct	Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF	380	5	3	3	4.3	Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)C1CCCCC1
CHEMBL6450	fpr1_human	Human	No	6.1	IC50	=	800	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL7226	fpr1_human	Human	No	6.1	IC50	=	800	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils		None	None	None		CSCC[C@H](NC(=O)NCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL6779	fpr1_human	Human	No	6.1	IC50	=	900	nM	Bind	Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils	586	14	5	5	3.7	CSCC[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL2372485	fpr1_human	Human	No	5.0	IC50	=	9200	nM	Bind	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells		None	None	None		C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
CHEMBL3311130	fpr1_human	Human	No	7.0	Kd	=	100	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	781	20	6	8	4.3	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](COC(C)(C)C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311298	fpr1_human	Human	No	6.9	Kd	=	120	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O
CHEMBL1916288	fpr1_human	Human	No	6.9	Kd	=	125.9	nM	Funct	Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level	483	6	2	6	4.2	Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C
CHEMBL3311144	fpr1_human	Human	No	6.9	Kd	=	130	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CSCC[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311292	fpr1_human	Human	No	6.9	Kd	=	130	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)O
CHEMBL3311294	fpr1_human	Human	No	6.9	Kd	=	130	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C(=O)O)[C@@H](C)OC(C)(C)C
CHEMBL3311037	fpr1_human	Human	No	6.9	Kd	=	140	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	795	20	6	8	4.7	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311140	fpr1_human	Human	No	6.9	Kd	=	140	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	870	24	7	8	5.1	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)c1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311139	fpr1_human	Human	No	6.8	Kd	=	150	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	877	24	7	8	5.3	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)C1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311291	fpr1_human	Human	No	6.8	Kd	=	150	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311297	fpr1_human	Human	No	6.8	Kd	=	150	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
CHEMBL3311299	fpr1_human	Human	No	6.8	Kd	=	150	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O
CHEMBL3311137	fpr1_human	Human	No	7.8	Kd	=	16	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	889	22	6	8	6.0	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311031	fpr1_human	Human	No	6.8	Kd	=	170	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311293	fpr1_human	Human	No	6.8	Kd	=	180	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](COC(C)(C)C)C(=O)O
CHEMBL1934424	fpr1_human	Human	No	7.7	Kd	=	20.0	nM	Funct	Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry	490	7	2	6	4.6	CO[C@H]1CC[C@@H](n2nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c2NS(=O)(=O)c2ccc(C)cc2)CC1
CHEMBL3311134	fpr1_human	Human	No	6.7	Kd	=	190	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311300	fpr1_human	Human	No	8.7	Kd	=	2.1	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	893	22	6	8	6.6	CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311036	fpr1_human	Human	No	6.7	Kd	=	200	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311142	fpr1_human	Human	No	6.7	Kd	=	200	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311030	fpr1_human	Human	Yes	6.6	Kd	=	230	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311143	fpr1_human	Human	No	7.6	Kd	=	25	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3309281	fpr1_human	Human	No	6.6	Kd	=	260	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C(=O)O)C(C)C
CHEMBL3311032	fpr1_human	Human	No	6.6	Kd	=	260	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311033	fpr1_human	Human	No	6.6	Kd	=	280	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL267179	fpr1_human	Human	Yes	8.5	Kd	=	3	nM	Bind	Binding affinity to human FPR1 receptorBinding affinity to human FPR1 receptor		None	None	None		None
CHEMBL3311035	fpr1_human	Human	No	6.5	Kd	=	350	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)O
CHEMBL1916282	fpr1_human	Human	No	6.4	Kd	=	398.1	nM	Funct	Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level	454	6	2	5	4.5	Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1
CHEMBL3311034	fpr1_human	Human	No	6.4	Kd	=	420	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311289	fpr1_human	Human	No	6.3	Kd	=	510	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311301	fpr1_human	Human	No	8.2	Kd	=	6.9	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	900	22	6	8	7.3	CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC1CCCCC1)C(=O)O
CHEMBL3311133	fpr1_human	Human	No	7.2	Kd	=	62	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	857	21	6	8	5.9	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311131	fpr1_human	Human	No	7.2	Kd	=	66	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	791	20	6	7	5.5	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311296	fpr1_human	Human	No	7.2	Kd	=	68	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccc(OC(C)(C)C)cc1)C(=O)O
CHEMBL3311136	fpr1_human	Human	No	7.2	Kd	=	69	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	925	20	6	10	6.5	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311138	fpr1_human	Human	No	6.1	Kd	=	730	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311132	fpr1_human	Human	No	7.1	Kd	=	75	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	819	20	6	7	5.4	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3311295	fpr1_human	Human	No	7.1	Kd	=	77	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC1CCCCC1)C(=O)O
CHEMBL1934426	fpr1_human	Human	No	6.1	Kd	=	794.3	nM	Funct	Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry	488	7	2	6	4.4	Cc1nn(C2CCOCC2)c(NS(=O)(=O)c2ccc(C3CC3)cc2)c1C(=O)N[C@@H](C)C(C)(C)C
CHEMBL3311288	fpr1_human	Human	No	6.1	Kd	=	830	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method		None	None	None		CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)OC(C)(C)C
CHEMBL3311135	fpr1_human	Human	No	7.1	Kd	=	90	nM	Funct	Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method	852	21	6	9	4.7	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1cn(C=O)c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL1329101	fpr1_human	Human	Yes	7.0	Ki	=	100	nM	Funct	Antagonist activity at FPR1Antagonist activity at FPR1	376	3	0	6	4.1	CCc1cc2c(cc1OC(=O)C)oc(c(c2=O)c1nc2c(n1C)cccc2)C
CHEMBL1487404	fpr1_human	Human	Yes	4.9	Ki	=	11500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	386	3	0	2	4.8	O=C1C(C23CC4CC(CC(C4)C2)C3)C(=O)N(c2ccccc2)N1c1ccccc1
CHEMBL1371060	fpr1_human	Human	No	4.9	Ki	=	11600	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	401	5	1	5	4.0	Cc1ccc(C2C(C(=O)c3ccc(Cl)cc3)=C(O)C(=O)N2CC2CCCO2)o1
CHEMBL1520286	fpr1_human	Human	Yes	4.9	Ki	=	12000	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	355	3	1	5	4.1	CCC(=O)Nc1c(C#N)c2nc3ccccc3nc2n1-c1ccccc1C
CHEMBL1611036	fpr1_human	Human	Yes	4.9	Ki	=	12400	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	349	5	1	5	3.7	O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1ccco1)c1ccco1
CHEMBL1599624	fpr1_human	Human	No	4.9	Ki	=	12500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	314	1	1	6	4.0	Cc1ccsc1C1C2=C(O)CC(C)(C)CC2=Nc2ncnn21
CHEMBL1438893	fpr1_human	Human	No	4.9	Ki	=	13500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	385	8	1	6	3.2	CCOc1cccc(C(=O)C2=C(O)C(=O)N(CCOC)C2c2ccc(C)o2)c1
CHEMBL1483985	fpr1_human	Human	Yes	4.9	Ki	=	13600	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	360	5	1	5	3.5	O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1ccncc1)c1ccco1
CHEMBL1561325	fpr1_human	Human	Yes	4.9	Ki	=	13800	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	449	10	1	7	4.2	CCCOc1ccc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCCn2ccnc2)cc1
CHEMBL1392442	fpr1_human	Human	No	4.9	Ki	=	14100	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	299	1	1	4	3.6	Cc1nn2c(O)c3c(nc2c1-c1ccc(Cl)cc1)CCC3
CHEMBL832	fpr1_human	Human	Yes	4.8	Ki	=	14400	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1
CHEMBL1367025	fpr1_human	Human	Yes	4.8	Ki	=	14500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	341	7	1	5	2.9	COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1ccccc1
CHEMBL1450917	fpr1_human	Human	Yes	4.8	Ki	=	14700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	419	7	1	5	3.7	COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1ccc(Br)cc1
CHEMBL1540596	fpr1_human	Human	Yes	4.8	Ki	=	14700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	345	2	2	5	3.2	O=C(NC1CCCC1)c1sc(=S)n2c1[nH]c(=O)c1ccccc12
CHEMBL1548838	fpr1_human	Human	Yes	4.8	Ki	=	15300	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	404	7	1	6	3.9	CCOc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2Cc2cccnc2)cc1
CHEMBL1563387	fpr1_human	Human	No	4.7	Ki	=	18300	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	341	5	1	7	2.5	CCOC(=O)Cc1cc(O)n2nc(C)c(-c3ccc(OC)cc3)c2n1
CHEMBL1588313	fpr1_human	Human	Yes	4.7	Ki	=	18400	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	382	7	2	4	3.5	CCN(C(=O)Cc1c(C(=O)O)[nH]c2ccccc12)c1cc(OC)ccc1OC
CHEMBL1417363	fpr1_human	Human	No	4.7	Ki	=	19000	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	345	4	1	6	3.2	CCOC(=O)Cc1cc(O)n2nc(C)c(-c3ccc(Cl)cc3)c2n1
CHEMBL1420005	fpr1_human	Human	Yes	4.7	Ki	=	19000	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	439	8	1	7	4.2	COc1ccc(CCN2C(=O)C(O)=C(C(=O)c3ccco3)C2c2cccs2)cc1OC
CHEMBL1517379	fpr1_human	Human	Yes	4.7	Ki	=	19400	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	392	5	0	7	4.7	COc1ccccc1Oc1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O
CHEMBL1509433	fpr1_human	Human	Yes	4.7	Ki	=	19600	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	333	4	2	5	3.1	CCCCNC(=O)c1sc(=S)n2c1[nH]c(=O)c1ccccc12
CHEMBL1441874	fpr1_human	Human	Yes	4.7	Ki	=	19700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	433	3	0	5	5.2	COc1ccc2ccccc2c1C1CC(=O)N2CN(C3CCCCC3)CSC2=C1C#N
CHEMBL1541719	fpr1_human	Human	Yes	4.7	Ki	=	19700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	433	7	2	6	4.1	COc1cc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCc2ccccc2)ccc1O
CHEMBL1602770	fpr1_human	Human	No	4.7	Ki	=	19700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	353	6	2	5	2.3	COc1ccccc1C1C(C(=O)c2ccccc2)=C(O)C(=O)N1CCO
CHEMBL1459454	fpr1_human	Human	No	4.7	Ki	=	20400	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	265	1	1	4	2.9	Cc1nn2c(O)c3c(nc2c1-c1ccccc1)CCC3
CHEMBL1336347	fpr1_human	Human	Yes	4.7	Ki	=	20500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	406	6	0	7	5.1	CCOc1ccccc1Oc1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O
CHEMBL1320528	fpr1_human	Human	No	4.7	Ki	=	20800	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	468	7	2	8	1.7	COC(=O)c1[nH]c(C)c(C(=O)C2=C(O)C(=O)N(CCN3CCOCC3)C2c2cccnc2)c1C
CHEMBL1466140	fpr1_human	Human	No	4.7	Ki	=	21100	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	411	7	1	6	3.7	CCOc1ccc(C(=O)C2=C(O)C(=O)N(CC3CCCO3)C2c2ccc(C)o2)cc1
CHEMBL1538195	fpr1_human	Human	Yes	4.7	Ki	=	21400	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	379	8	2	7	2.4	O=C(C1=C(O)C(=O)N(CCOCCO)C1c1cccs1)c1cccs1
CHEMBL1304907	fpr1_human	Human	No	4.7	Ki	=	21700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	216	1	1	5	1.5	CCc1c(C)nc2c(C#N)c(C)nn2c1O
CHEMBL3194619	fpr1_human	Human	No	4.6	Ki	=	22800	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	298	2	0	5	2.1	CC(=O)SCC(=O)/N=c1\sc2cc(F)ccc2n1C
CHEMBL1300796	fpr1_human	Human	Yes	4.6	Ki	=	22900	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	339	3	1	5	4.1	Cc1cccc(-n2nc3c(c2NC(=O)c2ccco2)CSC3)c1C
CHEMBL1351384	fpr1_human	Human	No	4.6	Ki	=	23200	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	476	7	1	8	3.0	Cc1ccc(C2C(C(=O)c3cnn(-c4ccccc4)c3C)=C(O)C(=O)N2CCN2CCOCC2)o1
CHEMBL1299357	fpr1_human	Human	Yes	4.6	Ki	=	24200	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	321	5	1	5	3.6	CCCCn1c(NC(=O)CC)c(C#N)c2nc3ccccc3nc21
CHEMBL1411390	fpr1_human	Human	No	4.6	Ki	=	24600	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	367	6	2	5	2.7	COc1ccccc1C1C(C(=O)c2ccccc2)=C(O)C(=O)N1CC(C)O
CHEMBL3185931	fpr1_human	Human	Yes	4.6	Ki	=	26400	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	456	9	1	8	2.6	COc1ccc(OC)c(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCCN2CCOCC2)c1
CHEMBL1529795	fpr1_human	Human	Yes	4.6	Ki	=	27000	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	455	8	1	8	4.1	COc1cc(C2C(C(=O)c3cccs3)=C(O)C(=O)N2Cc2ccco2)cc(OC)c1OC
CHEMBL1519083	fpr1_human	Human	No	4.6	Ki	=	27400	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	264	2	1	5	2.2	Cc1nc2c(C#N)cnn2c(O)c1Cc1ccccc1
CHEMBL1342311	fpr1_human	Human	No	4.5	Ki	=	29600	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	395	7	1	6	3.0	COCCCN1C(=O)C(O)=C(C(=O)c2ccccc2)C1c1ccc2c(c1)OCO2
CHEMBL1301382	fpr1_human	Human	Yes	4.5	Ki	=	29700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	417	10	3	8	1.7	COCc1cc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCOCCO)ccc1O
CHEMBL1334790	fpr1_human	Human	Yes	4.5	Ki	=	30300	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	240	6	1	5	2.0	C=CCn1c(SCCCC)nc(O)cc1=O
CHEMBL1530728	fpr1_human	Human	Yes	4.5	Ki	=	30400	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	447	8	2	6	4.5	CCOc1cc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCc2ccccc2)ccc1O
CHEMBL1866204	fpr1_human	Human	Yes	4.5	Ki	=	30500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	360	5	1	5	3.5	O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1cccnc1)c1ccco1
CHEMBL1370753	fpr1_human	Human	Yes	4.5	Ki	=	31200	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	419	7	1	5	3.7	COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1cccc(Br)c1
CHEMBL1731167	fpr1_human	Human	Yes	4.5	Ki	=	31700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	279	5	1	3	3.0	CCc1ccccc1NC(=O)C(C#N)Cc1cccnc1
CHEMBL1384171	fpr1_human	Human	No	4.5	Ki	=	32000	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	397	7	1	6	3.4	CCOc1ccc(C(=O)C2=C(O)C(=O)N(CC3CCCO3)C2c2ccco2)cc1
CHEMBL517444	fpr1_human	Human	Yes	4.5	Ki	=	32500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	486	3	2	7	4.5	COc1cc(-n2nc(C)c3c2OC(N)=C(C#N)C3c2ccccc2)c(Cl)c(Br)c1O
CHEMBL1323550	fpr1_human	Human	Yes	4.5	Ki	=	32900	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	467	8	1	7	4.6	COc1ccc(-n2c(Cc3cccn3C)nnc2SCC(=O)Nc2ccc(Cl)cc2)cc1
CHEMBL1526212	fpr1_human	Human	No	5.5	Ki	=	3400	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	419	7	1	6	4.1	COc1ccc(OC)c(C2C(C(=O)c3ccccc3)=C(O)C(=O)N2Cc2ccco2)c1
CHEMBL1309430	fpr1_human	Human	Yes	4.5	Ki	=	34100	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	463	6	2	8	3.7	O=C(O)CCCNc1cc(N2CCC3(CC2)OCCO3)c2noc3c2c1C(=O)c1ccccc1-3
CHEMBL1327566	fpr1_human	Human	Yes	4.5	Ki	=	35200	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	365	5	1	5	4.1	O=C(C1=C(O)C(=O)N(Cc2ccco2)C1c1ccccc1)c1cccs1
CHEMBL1407375	fpr1_human	Human	Yes	4.5	Ki	=	35500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	359	6	2	6	3.2	CCC(Sc1nc(O)c2c(n1)CCC2)C(=O)Nc1cccc(OC)c1
CHEMBL2140184	fpr1_human	Human	Yes	4.4	Ki	=	36400	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	363	4	1	3	3.6	O=C(NCc1cccnc1)C1c2ccccc2C(=O)N1C1CCCCCC1
CHEMBL1587683	fpr1_human	Human	Yes	4.4	Ki	=	36600	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	460	6	1	8	4.5	COc1ccc(OC)c(C2C(C(=O)c3cc4ccccc4o3)=C(O)C(=O)N2c2cc(C)on2)c1
CHEMBL1521564	fpr1_human	Human	No	4.4	Ki	=	36800	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	311	4	1	6	2.5	CCOC(=O)Cc1cc(O)n2nc(C)c(-c3ccccc3)c2n1
CHEMBL1539091	fpr1_human	Human	Yes	4.4	Ki	=	36900	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	433	8	1	6	4.1	COc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCc2ccccc2)cc1OC
CHEMBL1487874	fpr1_human	Human	Yes	4.4	Ki	=	37000	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	454	4	1	5	3.6	Cc1c(C(=O)NC2CCCc3ccccc32)oc2ccc(S(=O)(=O)N3CCOCC3)cc12
CHEMBL1529812	fpr1_human	Human	Yes	4.4	Ki	=	37600	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	478	6	1	7	4.6	CCC(SC1=Nc2ccccc2C2=NC(CC(C)C)C(=O)N12)C(=O)Nc1ccc2c(c1)OCO2
CHEMBL1603724	fpr1_human	Human	No	4.4	Ki	=	38600	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	397	7	2	6	2.7	COc1ccc(C2C(C(=O)c3ccccc3)=C(O)C(=O)N2CC(C)O)c(OC)c1
CHEMBL1424261	fpr1_human	Human	Yes	4.4	Ki	=	40500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	439	7	1	8	4.3	C=CCOc1ccc(C2C(C(=O)c3cccs3)=C(O)C(=O)N2c2nnc(C)s2)cc1
CHEMBL1333773	fpr1_human	Human	Yes	4.4	Ki	=	40600	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	359	2	2	5	3.6	O=C(NC1CCCCC1)c1sc(=S)n2c1[nH]c(=O)c1ccccc12
CHEMBL1501475	fpr1_human	Human	Yes	4.4	Ki	=	40700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	474	8	3	7	3.4	CCCCCNC(=O)c1ccc2c(=O)[nH]c3c(C(=O)NCC4CCCO4)sc(=S)n3c2c1
CHEMBL1741640	fpr1_human	Human	Yes	4.4	Ki	=	40900	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	377	4	1	3	4.0	O=C(NCc1cccnc1)C1c2ccccc2C(=O)N1C1CCCCCCC1
CHEMBL1453327	fpr1_human	Human	Yes	4.4	Ki	=	41200	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	442	5	3	4	4.9	Cc1sc(NC(=O)C2CCCCC2C(=O)O)c(C(N)=O)c1-c1ccc(C(C)(C)C)cc1
CHEMBL1569039	fpr1_human	Human	Yes	4.4	Ki	=	41500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	433	7	2	7	2.6	CC(C)OC(=O)c1cc(NC(=O)C2C3CCC(O3)C2C(=O)O)cc(C(=O)OC(C)C)c1
CHEMBL267179	fpr1_human	Human	Yes	7.4	Ki	=	42	nM	Bind	Displacement of [3H]-fMLP from FPR in human neutrophilsDisplacement of [3H]-fMLP from FPR in human neutrophils		None	None	None		None
CHEMBL1323117	fpr1_human	Human	Yes	4.4	Ki	=	42700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	432	8	1	6	4.6	CCCOc1ccc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2Cc2cccnc2)cc1
CHEMBL1585547	fpr1_human	Human	No	4.4	Ki	=	43000	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	447	7	1	7	3.9	COC(=O)c1ccc(C2C(C(=O)c3ccc(OC)cc3)=C(O)C(=O)N2Cc2ccco2)cc1
CHEMBL1313648	fpr1_human	Human	Yes	4.4	Ki	=	43100	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	230	3	1	3	4.1	Cc1ccc(Nc2nc(C3CC3)cs2)cc1
CHEMBL1312768	fpr1_human	Human	Yes	4.3	Ki	=	45700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	307	4	1	5	3.2	CCCCn1c(NC(C)=O)c(C#N)c2nc3ccccc3nc21
CHEMBL1307438	fpr1_human	Human	Yes	4.3	Ki	=	47700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	474	5	2	8	3.8	COc1cc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2c2cc(C)on2)cc(Br)c1O
CHEMBL1367155	fpr1_human	Human	No	4.3	Ki	=	47900	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	367	1	3	6	4.6	Cc1ccc(C2C3=C(O)CC(C)(C)CC3=Nc3nc(S)nc(O)c32)cc1
CHEMBL1607212	fpr1_human	Human	Yes	4.3	Ki	=	49600	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	316	4	1	6	2.6	COc1ccc(OC)c(C(=O)c2nc3c(n2O)CCCCC3)c1
CHEMBL3191155	fpr1_human	Human	No	4.3	Ki	=	49800	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	401	5	1	5	3.4	CCC(CC)C(=O)/N=c1\c2cnn(-c3ccccc3)c2[nH]c(=O)n1-c1ccccc1
CHEMBL1339330	fpr1_human	Human	No	5.3	Ki	=	5000	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	473	7	2	8	2.4	COC(=O)c1[nH]c(C)c(C(=O)C2=C(O)C(=O)N(CCN3CCOCC3)C2c2cccs2)c1C
CHEMBL1538337	fpr1_human	Human	No	4.3	Ki	=	50000	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	278	2	1	5	2.5	Cc1nc2c(C#N)c(C)nn2c(O)c1Cc1ccccc1
CHEMBL1568452	fpr1_human	Human	Yes	4.3	Ki	=	50000	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	383	5	1	10	1.4	CC(C)OC(=O)c1nnn(-c2nonc2N)c1CN1CCc2ccccc2C1
CHEMBL101	fpr1_human	Human	Yes	5.3	Ki	=	5300	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	308	5	0	2	3.8	CCCCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O
CHEMBL1368337	fpr1_human	Human	No	4.3	Ki	=	53700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	315	1	1	4	4.1	Cc1nn2c(O)c3c(nc2c1-c1cccc2ccccc12)CCC3
CHEMBL1535358	fpr1_human	Human	Yes	4.3	Ki	=	54800	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	354	5	1	6	2.4	O=C(C1=C(O)C(=O)N(CC2CCCO2)C1c1cccnc1)c1ccco1
CHEMBL1477329	fpr1_human	Human	No	5.3	Ki	=	5500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	365	6	1	4	3.9	COc1ccccc1C1C(C(=O)c2ccccc2)=C(O)C(=O)N1CC(C)C
CHEMBL1537448	fpr1_human	Human	Yes	4.3	Ki	=	56000	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	419	8	1	6	4.3	COCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1cccc(Oc2ccccc2)c1
CHEMBL1723342	fpr1_human	Human	Yes	4.2	Ki	=	57100	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	437	9	1	7	4.0	CCOc1ccc(C2C(C(=O)c3cccs3)=C(O)C(=O)N2CCCn2ccnc2)cc1
CHEMBL1389122	fpr1_human	Human	No	4.2	Ki	=	57500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	489	8	2	8	3.6	COc1cc(C2C(C(=O)c3ccc4c(c3)CC(C)O4)=C(O)C(=O)N2CCCn2ccnc2)ccc1O
CHEMBL1496459	fpr1_human	Human	No	4.2	Ki	=	57700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	424	6	1	7	4.5	CCOc1ccc(C(=O)C2=C(O)C(=O)N(c3nc(C)c(C)s3)C2c2ccco2)cc1
CHEMBL1562262	fpr1_human	Human	Yes	4.2	Ki	=	60700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	447	7	1	7	3.1	O=C(C1=C(O)C(=O)N(CCCN2CCOCC2)C1c1ccccn1)c1cc2ccccc2o1
CHEMBL1303183	fpr1_human	Human	Yes	4.2	Ki	=	61100	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	440	7	2	9	4.0	CCc1nnc(NC(=O)CSc2nnc(-c3cc4ccccc4cc3O)n2CC)s1
CHEMBL1309064	fpr1_human	Human	Yes	4.2	Ki	=	63300	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	481	9	2	8	3.7	COc1ccccc1-n1c(CNC(=O)c2ccco2)nnc1SCC(=O)Nc1ccc(F)cc1
CHEMBL1546060	fpr1_human	Human	Yes	4.2	Ki	=	63300	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	443	6	2	6	4.0	CCOC(=O)c1c(NC(=O)C2C3CCC(O3)C2C(=O)O)sc(C)c1-c1ccc(C)cc1
CHEMBL1223	fpr1_human	Human	Yes	5.1	Ki	=	7800	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	334	4	2	4	0.9	CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O
CHEMBL29	fpr1_human	Human	Yes	5.1	Ki	=	7800	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	334	4	2	4	0.9	CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O
CHEMBL1487270	fpr1_human	Human	Yes	5.1	Ki	=	8500	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	325	8	0	3	2.7	CC(C)CN(CC(C)C)C(=O)CS(=O)(=O)Cc1ccccc1
CHEMBL1388022	fpr1_human	Human	Yes	5.1	Ki	=	9000	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	376	4	0	6	4.6	COc1ccccc1-c1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O
CHEMBL1560619	fpr1_human	Human	Yes	5.0	Ki	=	9300	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	498	7	2	10	4.0	COc1ccc(Cl)cc1-n1c(=S)sc2c(O)nc(SCC(=O)NCC3CCCO3)nc21
CHEMBL1517647	fpr1_human	Human	Yes	5.0	Ki	=	9700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	416	8	1	6	4.0	C=CCOc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2Cc2cccnc2)cc1
CHEMBL1528253	fpr1_human	Human	No	5.0	Ki	=	9700	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	482	8	2	8	2.1	COC(=O)c1[nH]c(C)c(C(=O)C2=C(O)C(=O)N(CCCN3CCOCC3)C2c2ccccn2)c1C
CHEMBL1344524	fpr1_human	Human	Yes	5.0	Ki	=	9900	nM	Funct	PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)	421	9	1	7	3.5	CCOc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCCn2ccnc2)cc1
CHEMBL267179	fpr1_human	Human	Yes	10.2	pEC50	=			Funct	UnclassifiedUnclassified		None	None	None		None
CHEMBL395493	fpr1_mouse	Mouse	No	3.9	pEC50	=			Funct	UnclassifiedUnclassified		None	None	None		None
CHEMBL267179	fpr1_mouse	Mouse	Yes	4.7	pEC50	=			Funct	UnclassifiedUnclassified		None	None	None		None
CHEMBL1290578	fpr1_human	Human	No	5.6	pEC50	=			Funct	UnclassifiedUnclassified	358	6	2	6	3.2	COc1ccc2c(c1)nc([nH]2)SCC(=O)Nc1ccc(cc1)[N+](=O)[O-]
CHEMBL160	fpr1_human	Human	Yes	6.3	pEC50	=			Funct	UnclassifiedUnclassified		None	None	None		None
CHEMBL4784510	fpr1_mouse	Mouse	Yes	6.3	pEC50	=			Funct	UnclassifiedUnclassified	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1
CHEMBL4784510	fpr1_human	Human	Yes	6.4	pEC50	=			Funct	UnclassifiedUnclassified	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1
CHEMBL1290251	fpr1_human	Human	No	7.4	pEC50	=			Funct	UnclassifiedUnclassified	404	7	1	6	3.8	COc1cc(/C=N/NC(=O)c2ccc3c(c2)OCO3)ccc1OCc1ccccc1
CHEMBL379761	fpr1_mouse	Mouse	Yes	8.7	pEC50	=			Funct	UnclassifiedUnclassified	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl
CHEMBL395493	fpr1_human	Human	No	4.3	pIC50	=			Funct	UnclassifiedUnclassified		None	None	None		None
CHEMBL832	fpr1_human	Human	Yes	5.0	pIC50	=			Funct	UnclassifiedUnclassified	404	6	0	3	3.8	O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1
CHEMBL1770295	fpr1_human	Human	Yes	5.3	pIC50	=			Funct	UnclassifiedUnclassified	376	3	1	5	2.3	CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C
CHEMBL1770297	fpr1_human	Human	Yes	6.3	pIC50	=			Funct	UnclassifiedUnclassified	423	8	2	5	5.2	CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC
CHEMBL1770298	fpr1_human	Human	No	6.5	pIC50	=			Funct	UnclassifiedUnclassified	394	5	3	4	4.5	Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O
CHEMBL240597	fpr1_human	Human	Yes	4.0	pKi	=			Funct	UnclassifiedUnclassified	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C
CHEMBL406393	fpr1_human	Human	Yes	4.0	pKi	=			Funct	UnclassifiedUnclassified	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C
CHEMBL1329101	fpr1_human	Human	Yes	7.0	pKi	=			Funct	UnclassifiedUnclassified	376	3	0	6	4.1	CCc1cc2c(cc1OC(=O)C)oc(c(c2=O)c1nc2c(n1C)cccc2)C

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