Ligand source activities (1 row/activity)





Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Potency)
# tested GPCRs
(Potency)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
44263999 203382 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL 558 15 5 6 3.3 COc1ccc(NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)O)cc1 10.1021/jm950908d
CHEMBL7753 203382 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL 558 15 5 6 3.3 COc1ccc(NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)O)cc1 10.1021/jm950908d
CHEMBL267388 208973 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
1022 1639 50 None 4897 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None None 10.1021/jm900592h
443295 1639 50 None 4897 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None None 10.1021/jm900592h
CHEMBL267179 1639 50 None 4897 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None None 10.1021/jm900592h
145952664 161883 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 500 9 3 4 4.6 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4166385 161883 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 500 9 3 4 4.6 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
71698968 90246 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 445 5 1 4 4.2 Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391281 90246 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 445 5 1 4 4.2 Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
44232677 194672 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 408 7 1 7 2.7 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc([N+](=O)[O-])cc3)c2=O)c1 10.1021/jm900592h
CHEMBL562456 194672 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 408 7 1 7 2.7 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc([N+](=O)[O-])cc3)c2=O)c1 10.1021/jm900592h
71698530 90241 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 509 7 1 5 5.3 COc1cccc(Cc2cc(C3CCCCC3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391257 90241 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 509 7 1 5 5.3 COc1cccc(Cc2cc(C3CCCCC3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
44233646 194749 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
CHEMBL562910 194749 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
44233646 194749 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
CHEMBL562910 194749 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
164916035 191752 0 None -16 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5207056 191752 0 None -16 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
71698446 90278 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 427 5 1 5 3.6 COc1ccc(-c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
CHEMBL2391452 90278 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 427 5 1 5 3.6 COc1ccc(-c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
44232924 193653 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551590 193653 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44232924 193653 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551590 193653 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
122487974 169846 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 497 9 1 5 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4448213 169846 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 497 9 1 5 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O 10.1021/acs.jmedchem.8b01912
168279295 190452 0 None -91 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187135 190452 0 None -91 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
71699142 90275 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 442 6 2 6 3.7 COc1ccc(Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
CHEMBL2391449 90275 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 442 6 2 6 3.7 COc1ccc(Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
71698365 90273 0 None -7 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 484 7 2 7 3.9 COc1ccc(Nc2c(C(C)=O)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
CHEMBL2391447 90273 0 None -7 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 484 7 2 7 3.9 COc1ccc(Nc2c(C(C)=O)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
71699061 90266 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 461 5 1 4 4.7 Cc1cc(Cc2cccc3ccccc23)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391438 90266 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 461 5 1 4 4.7 Cc1cc(Cc2cccc3ccccc23)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
146597625 190668 1 None -47 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 420 5 2 6 3.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5190385 190668 1 None -47 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 420 5 2 6 3.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
168286767 191086 0 None -53 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5196551 191086 0 None -53 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
145949892 162270 0 None -2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4172556 162270 0 None -2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
168279956 190489 0 None -4 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187563 190489 0 None -4 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
168283359 190218 0 None -5 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5183856 190218 0 None -5 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
155519369 169810 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 441 7 1 6 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1OC 10.1021/acs.jmedchem.8b01912
CHEMBL4447830 169810 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 441 7 1 6 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1OC 10.1021/acs.jmedchem.8b01912
44233647 193862 0 None -1 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
CHEMBL554291 193862 0 None -1 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
54580795 61147 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assayAgonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay
ChEMBL 424 8 2 6 4.6 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
CHEMBL1770476 61147 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assayAgonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay
ChEMBL 424 8 2 6 4.6 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
44236330 193162 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL539401 193162 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
44236330 193162 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL539401 193162 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
168292800 191464 0 None -3 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5202577 191464 0 None -3 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
155516247 169462 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4442702 169462 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL5076914 212698 4 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 expressed in HEK293-A cells assessed as ERK phosphorylation level incubated for 5 mins by ELISA assayAgonist activity at human FPR1 expressed in HEK293-A cells assessed as ERK phosphorylation level incubated for 5 mins by ELISA assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(c2ccccc2)C1=O 10.1016/j.ejmech.2021.113805
168282160 190256 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184490 190256 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
168278342 190557 0 None 1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5188537 190557 0 None 1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
145953127 161889 0 None -9 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 470 8 4 2 4.9 O=C(Nc1ccc(F)cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4166447 161889 0 None -9 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 470 8 4 2 4.9 O=C(Nc1ccc(F)cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL266802 208955 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1ccc(C)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
1022 1639 50 None 4897 3 Human 7.7 pEC50 = 7.7 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None None 10.1021/jm950908d
443295 1639 50 None 4897 3 Human 7.7 pEC50 = 7.7 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None None 10.1021/jm950908d
CHEMBL267179 1639 50 None 4897 3 Human 7.7 pEC50 = 7.7 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None None 10.1021/jm950908d
44233648 193397 0 None -2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL549570 193397 0 None -2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
44233648 193397 0 None -2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL549570 193397 0 None -2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
168280238 190360 0 None -6 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185921 190360 0 None -6 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
155519289 169797 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 427 7 1 6 3.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1OC 10.1021/acs.jmedchem.8b01912
CHEMBL4447632 169797 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 427 7 1 6 3.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1OC 10.1021/acs.jmedchem.8b01912
44232675 193990 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
CHEMBL556485 193990 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
145978177 162511 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 452 8 4 2 4.7 O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4176353 162511 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 452 8 4 2 4.7 O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
168283038 190333 0 None -16 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185462 190333 0 None -16 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
122487986 175401 0 None 1 2 Human 4.6 pEC50 = 4.6 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL4588649 175401 0 None 1 2 Human 4.6 pEC50 = 4.6 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
122181231 121193 0 None -3 3 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL3588871 121193 0 None -3 3 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.ejmech.2017.09.023
44236328 194003 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL556625 194003 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
44236326 193652 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551589 193652 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44236326 193652 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551589 193652 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
168281748 190291 0 None -6 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184913 190291 0 None -6 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
168283383 190250 0 None -3 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184396 190250 0 None -3 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
44233644 194416 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL560780 194416 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
145952485 162303 0 None -2 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4172968 162303 0 None -2 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
155538591 171839 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 427 7 1 6 3.5 COc1cccc(OC)c1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4476616 171839 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 427 7 1 6 3.5 COc1cccc(OC)c1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
168282231 190368 0 None -16 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185982 190368 0 None -16 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
168291793 191334 0 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5200365 191334 0 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
71699063 90269 0 None -1 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 454 6 2 5 2.6 Cc1cc(Cc2ccc(C(N)=O)cc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391440 90269 0 None -1 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 454 6 2 5 2.6 Cc1cc(Cc2ccc(C(N)=O)cc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL265408 208902 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None CCCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
71698362 90272 0 None -3 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 455 6 1 6 3.2 COc1cccc(C(=O)c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391446 90272 0 None -3 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 455 6 1 6 3.2 COc1cccc(C(=O)c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL7306 214095 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
24776341 3188 33 None -20 4 Human 7.5 pEC50 = 7.5 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
5831 3188 33 None -20 4 Human 7.5 pEC50 = 7.5 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
CHEMBL379761 3188 33 None -20 4 Human 7.5 pEC50 = 7.5 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
164916036 190991 0 None -147 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5195186 190991 0 None -147 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
44232925 194974 2 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL564392 194974 2 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44233644 194416 0 None 1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL560780 194416 0 None 1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
44233645 194511 0 None -5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 363 6 1 5 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 10.1021/jm900592h
CHEMBL561375 194511 0 None -5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 363 6 1 5 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 10.1021/jm900592h
44233644 194416 0 None 1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL560780 194416 0 None 1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
44233645 194511 0 None -5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 363 6 1 5 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 10.1021/jm900592h
CHEMBL561375 194511 0 None -5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 363 6 1 5 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 10.1021/jm900592h
168283929 190506 0 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187763 190506 0 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
44236326 193652 0 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551589 193652 0 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44233647 193862 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
CHEMBL554291 193862 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
44232675 193990 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
CHEMBL556485 193990 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
44233647 193862 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
CHEMBL554291 193862 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
44232675 193990 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
CHEMBL556485 193990 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
44236329 193776 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL552396 193776 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
44236329 193776 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL552396 193776 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL7520 214098 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
11024 681 14 None -794 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
122583088 681 14 None -794 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL4784510 681 14 None -794 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
11024 681 14 None -794 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acsmedchemlett.2c00079
122583088 681 14 None -794 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acsmedchemlett.2c00079
CHEMBL4784510 681 14 None -794 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acsmedchemlett.2c00079
168296342 191849 0 None -2 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5208434 191849 0 None -2 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
71698528 90239 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 503 7 1 5 3.6 CCc1cc(Cc2cccc(OC)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391255 90239 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 503 7 1 5 3.6 CCc1cc(Cc2cccc(OC)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1 10.1016/j.ejmech.2013.03.066
168274924 189675 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5175543 189675 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
168273654 189732 0 None -6 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5176452 189732 0 None -6 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
122181231 121193 0 None -3 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3588871 121193 0 None -3 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
44233905 194659 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
CHEMBL562380 194659 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
44233905 194659 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
CHEMBL562380 194659 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
168281597 190676 0 None -50 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5190571 190676 0 None -50 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
145956361 161462 0 None 2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4159569 161462 0 None 2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
71698529 90240 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 469 7 1 5 4.4 COc1cccc(Cc2cc(C(C)C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391256 90240 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 469 7 1 5 4.4 COc1cccc(Cc2cc(C(C)C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
71699059 90248 0 None 3 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 417 5 1 5 3.6 Cc1cc(Cc2ccsc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391286 90248 0 None 3 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 417 5 1 5 3.6 Cc1cc(Cc2ccsc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
146597621 190743 0 None -33 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 419 5 2 5 4.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)on2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5191583 190743 0 None -33 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 419 5 2 5 4.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)on2)c(F)c1 10.1021/acsmedchemlett.2c00079
145956762 161619 0 None -1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4162303 161619 0 None -1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
163322252 191283 3 None -26 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5199629 191283 3 None -26 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
457933 213946 20 None -501 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](CCSC)C(N)=O)C(C)C 10.1021/jm900592h
CHEMBL552527 213946 20 None -501 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](CCSC)C(N)=O)C(C)C 10.1021/jm900592h
11024 681 14 None -524 4 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
122583088 681 14 None -524 4 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL4784510 681 14 None -524 4 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
145958736 161667 0 None -6 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4162930 161667 0 None -6 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
155555898 173795 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4551649 173795 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O 10.1021/acs.jmedchem.8b01912
146035589 173157 0 None -1 2 Human 7.3 pEC50 = 7.3 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 483 10 1 6 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4536334 173157 0 None -1 2 Human 7.3 pEC50 = 7.3 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 483 10 1 6 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
145951856 162341 0 None -8 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4173645 162341 0 None -8 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
71698880 90243 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 411 5 1 4 3.5 Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391277 90243 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 411 5 1 4 3.5 Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
162425412 190474 0 None -21 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 386 5 2 6 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccccc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5187399 190474 0 None -21 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 386 5 2 6 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccccc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
168278240 190507 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187767 190507 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
44233648 193397 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL549570 193397 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
71698972 90247 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 401 5 1 5 3.1 Cc1cc(Cc2ccoc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391285 90247 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 401 5 1 5 3.1 Cc1cc(Cc2ccoc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
145955803 162096 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 488 8 3 3 4.7 Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F 10.1016/j.ejmech.2017.09.023
CHEMBL4169807 162096 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 488 8 3 3 4.7 Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F 10.1016/j.ejmech.2017.09.023
154706263 172997 2 None - 1 Human 8.2 pEC50 = 8.2 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 527 10 1 6 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4532583 172997 2 None - 1 Human 8.2 pEC50 = 8.2 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 527 10 1 6 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
146035588 170329 2 None -5 2 Human 6.2 pEC50 = 6.2 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4454594 170329 2 None -5 2 Human 6.2 pEC50 = 6.2 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
71698527 90238 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 427 6 1 5 3.2 COc1cccc(Cc2ccnn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391254 90238 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 427 6 1 5 3.2 COc1cccc(Cc2ccnn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
145956276 162126 0 None 1 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4170201 162126 0 None 1 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
122488043 173694 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 427 7 1 6 3.5 COc1ccc(OC)c(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL4549250 173694 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 427 7 1 6 3.5 COc1ccc(OC)c(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
71698967 90245 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 429 5 1 4 3.7 Cc1cc(Cc2cccc(F)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391280 90245 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 429 5 1 4 3.7 Cc1cc(Cc2cccc(F)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
44236328 194003 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL556625 194003 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
44236328 194003 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL556625 194003 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
168269851 189373 0 None -3 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5170711 189373 0 None -3 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
168278228 190486 0 None -3 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187530 190486 0 None -3 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
71698966 90244 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 377 5 1 6 2.5 Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc3c(c2)OCO3)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391279 90244 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 377 5 1 6 2.5 Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc3c(c2)OCO3)n1 10.1016/j.ejmech.2013.03.066
168284664 190917 0 None -7 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 488 5 2 3 4.9 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)Cc2cc(F)ccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5193947 190917 0 None -7 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 488 5 2 3 4.9 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)Cc2cc(F)ccc21 10.1021/acs.jmedchem.1c02203
44236330 193162 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL539401 193162 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
71699065 90270 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 519 7 1 6 3.4 COc1cc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)cc(OC)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391442 90270 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 519 7 1 6 3.4 COc1cc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)cc(OC)c1 10.1016/j.ejmech.2013.03.066
44236329 193776 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL552396 193776 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
44233646 194749 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
CHEMBL562910 194749 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
164916034 191094 0 None -6 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5196771 191094 0 None -6 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
44232925 194974 2 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL564392 194974 2 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44232925 194974 2 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL564392 194974 2 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
71699060 90265 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 417 5 1 5 3.6 Cc1cc(Cc2cccs2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391437 90265 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 417 5 1 5 3.6 Cc1cc(Cc2cccs2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
71698442 90274 0 None 3 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 336 3 2 5 1.5 Cc1cc(N)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391448 90274 0 None 3 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 336 3 2 5 1.5 Cc1cc(N)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
145963525 161773 0 None 2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4164673 161773 0 None 2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
146035588 170329 2 None -5 2 Human 6.1 pEC50 = 6.1 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4454594 170329 2 None -5 2 Human 6.1 pEC50 = 6.1 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL6997 214089 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1cccc(C)c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
71698531 90242 0 None -2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 503 7 1 5 4.9 COc1cccc(Cc2cc(-c3ccccc3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391258 90242 0 None -2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 503 7 1 5 4.9 COc1cccc(Cc2cc(-c3ccccc3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
168272319 189981 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5180261 189981 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
71699062 90267 0 None -3 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 412 5 1 5 2.9 Cc1cc(Cc2cccnc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391439 90267 0 None -3 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 412 5 1 5 2.9 Cc1cc(Cc2cccnc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
71699143 90277 0 None -3 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 470 6 2 6 3.2 COc1cccc(C(=O)Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391450 90277 0 None -3 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 470 6 2 6 3.2 COc1cccc(C(=O)Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
145954612 162020 0 None -2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 482 9 4 3 4.8 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4168567 162020 0 None -2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 482 9 4 3 4.8 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
122181322 121349 0 None -1 3 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590073 121349 0 None -1 3 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
71699139 90271 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 493 5 1 4 4.0 Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391443 90271 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 493 5 1 4 4.0 Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1 10.1016/j.ejmech.2013.03.066
44232924 193653 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551590 193653 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
155555363 173802 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 439 8 1 5 4.8 CCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4551842 173802 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 439 8 1 5 4.8 CCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL1628710 55981 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL None None None None 10.1016/j.bmcl.2011.03.049
CHEMBL6450 214077 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
57399909 67944 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 452 6 2 5 4.3 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916276 67944 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 452 6 2 5 4.3 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57398259 67953 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 446 6 2 5 4.4 Cc1nn(-c2ccccc2)c(NS(=O)(=O)C2CCCCC2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
CHEMBL1916286 67953 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 446 6 2 5 4.4 Cc1nn(-c2ccccc2)c(NS(=O)(=O)C2CCCCC2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
57394708 67954 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 459 6 2 6 3.7 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2cccnc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
CHEMBL1916287 67954 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 459 6 2 6 3.7 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2cccnc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
57396213 69228 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 420 6 2 5 4.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934267 69228 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 420 6 2 5 4.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)C)cc1 10.1016/j.bmcl.2011.10.090
57390868 69252 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 448 6 2 6 3.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934423 69252 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 448 6 2 6 3.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOC2)cc1 10.1016/j.bmcl.2011.10.090
54580795 61147 0 None - 1 Human 6.0 pIC50 = 6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 424 8 2 6 4.6 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
CHEMBL1770476 61147 0 None - 1 Human 6.0 pIC50 = 6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 424 8 2 6 4.6 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
54580798 61153 0 None - 1 Human 6.0 pIC50 = 6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 391 7 2 4 5.3 CCC[C@H](NC(=O)c1oc2ccc(OCC)cc2c1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770484 61153 0 None - 1 Human 6.0 pIC50 = 6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 391 7 2 4 5.3 CCC[C@H](NC(=O)c1oc2ccc(OCC)cc2c1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
2528 3644 81 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 10.1016/j.bmcl.2011.03.049
5342 3644 81 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 10.1016/j.bmcl.2011.03.049
5826 3644 81 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 10.1016/j.bmcl.2011.03.049
CHEMBL832 3644 81 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 10.1016/j.bmcl.2011.03.049
DB01138 3644 81 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 10.1016/j.bmcl.2011.03.049
57394598 67908 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 446 7 2 5 3.9 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccccc3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916086 67908 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 446 7 2 5 3.9 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccccc3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57401587 67925 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 6 2 6 2.9 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916257 67925 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 6 2 6 2.9 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57394706 67931 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1cn(-c2ccccc2)nc1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916263 67931 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1cn(-c2ccccc2)nc1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57401680 67932 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 460 8 2 5 4.6 CCC(CC)NC(=O)c1cnn(-c2ccccc2Cl)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916264 67932 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 460 8 2 5 4.6 CCC(CC)NC(=O)c1cnn(-c2ccccc2Cl)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57403415 67936 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 392 8 2 5 3.5 CCC(CC)NC(=O)c1cnn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916268 67936 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 392 8 2 5 3.5 CCC(CC)NC(=O)c1cnn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57397970 69248 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 510 6 2 7 3.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCS(=O)(=O)CC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934419 69248 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 510 6 2 7 3.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCS(=O)(=O)CC2)cc1 10.1016/j.bmcl.2011.10.090
54586641 61085 0 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 388 5 2 3 4.5 Cc1cccc(C)c1NC(=O)C(c1ccccc1)N(C)C(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770308 61085 0 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 388 5 2 3 4.5 Cc1cccc(C)c1NC(=O)C(c1ccccc1)N(C)C(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
24244526 61141 4 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 327 6 2 5 2.6 CSCCC(NC(=O)c1cnccn1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770469 61141 4 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 327 6 2 5 2.6 CSCCC(NC(=O)c1cnccn1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
54583762 61142 0 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 330 6 2 5 3.1 CSCCC(NC(=O)c1ocnc1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770470 61142 0 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 330 6 2 5 3.1 CSCCC(NC(=O)c1ocnc1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
5126271 61144 1 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 339 6 2 3 4.1 CSCCC(NC(=O)c1ccc(C)cc1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770472 61144 1 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 339 6 2 3 4.1 CSCCC(NC(=O)c1ccc(C)cc1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
54582778 61152 0 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 441 7 2 6 3.5 CCOc1ccc2oc(C(=O)NC(CS(C)(=O)=O)c3nc4ccccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
CHEMBL1770482 61152 0 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 441 7 2 6 3.5 CCOc1ccc2oc(C(=O)NC(CS(C)(=O)=O)c3nc4ccccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
155517073 169595 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4444413 169595 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
155529906 170906 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 421 8 3 4 2.8 COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C 10.1039/C9MD00336C
CHEMBL4463562 170906 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 421 8 3 4 2.8 COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C 10.1039/C9MD00336C
57398260 67956 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 526 6 2 5 5.3 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
CHEMBL1916289 67956 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 526 6 2 5 5.3 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
71698276 173227 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 4.1 COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4538076 173227 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 4.1 COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
57398258 67949 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916281 67949 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
3089940 61061 2 None - 1 Human 5.9 pIC50 = 5.9 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 374 5 3 3 4.1 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccccc1 10.1016/j.bmcl.2011.03.049
CHEMBL1770153 61061 2 None - 1 Human 5.9 pIC50 = 5.9 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 374 5 3 3 4.1 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccccc1 10.1016/j.bmcl.2011.03.049
92263206 173601 0 None -1 2 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 465 8 3 5 3.5 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1039/C9MD00336C
CHEMBL4547265 173601 0 None -1 2 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 465 8 3 5 3.5 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1039/C9MD00336C
118707168 112522 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 893 22 6 8 6.6 CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311300 112522 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 893 22 6 8 6.6 CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
155524563 170358 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 435 9 3 4 3.2 COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4455225 170358 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 435 9 3 4 3.2 COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
168286767 191086 0 None -53 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5196551 191086 0 None -53 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
4329947 2465 1 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
5829 2465 1 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
CHEMBL1770297 2465 1 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
57392963 67945 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 466 6 2 5 4.6 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916277 67945 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 466 6 2 5 4.6 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57399910 67948 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 7 2 5 3.8 CCC(C)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916280 67948 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 7 2 5 3.8 CCC(C)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
56949966 69254 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 488 7 2 6 4.4 Cc1nn(C2CCOCC2)c(NS(=O)(=O)c2ccc(C3CC3)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.10.090
CHEMBL1934426 69254 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 488 7 2 6 4.4 Cc1nn(C2CCOCC2)c(NS(=O)(=O)c2ccc(C3CC3)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.10.090
53233899 1384 0 None 69 2 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5830 1384 0 None 69 2 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770298 1384 0 None 69 2 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
57392872 67907 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 452 6 1 5 4.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916085 67907 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 452 6 1 5 4.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57399908 67930 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1ncn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916262 67930 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1ncn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57399672 69231 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 434 5 2 5 4.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)(C)C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934270 69231 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 434 5 2 5 4.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)(C)C)cc1 10.1016/j.bmcl.2011.10.090
54581781 61080 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 378 5 3 5 2.9 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1cn(C)cn1 10.1016/j.bmcl.2011.03.049
CHEMBL1770301 61080 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 378 5 3 5 2.9 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1cn(C)cn1 10.1016/j.bmcl.2011.03.049
57396467 67933 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 451 8 2 6 3.8 CCC(CC)NC(=O)c1cnn(-c2ccc(C#N)cc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916265 67933 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 451 8 2 6 3.8 CCC(CC)NC(=O)c1cnn(-c2ccc(C#N)cc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL6997 214089 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1cccc(C)c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
117993763 171038 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4465341 171038 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
92263206 173601 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 465 8 3 5 3.5 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1039/C9MD00336C
CHEMBL4547265 173601 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 465 8 3 5 3.5 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1039/C9MD00336C
168281597 190676 0 None -50 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5190571 190676 0 None -50 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
164916036 190991 0 None -147 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5195186 190991 0 None -147 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
71697968 173999 17 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4556626 173999 17 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
155510570 173459 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 449 10 3 4 3.1 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C 10.1039/C9MD00336C
CHEMBL4543372 173459 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 449 10 3 4 3.1 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C 10.1039/C9MD00336C
57401368 69242 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 432 6 2 5 4.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934413 69242 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 432 6 2 5 4.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCC2)cc1 10.1016/j.bmcl.2011.10.090
57399796 67905 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916082 67905 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57401684 67947 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 6 2 5 4.1 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCC(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916279 67947 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 6 2 5 4.1 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCC(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
54581826 61143 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 365 6 2 4 4.5 CSCCC(NC(=O)c1sccc1Cl)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770471 61143 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 365 6 2 4 4.5 CSCCC(NC(=O)c1sccc1Cl)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
57398252 67934 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 427 8 2 6 3.3 CCC(CC)NC(=O)c1cnn(-c2ccccn2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916266 67934 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 427 8 2 6 3.3 CCC(CC)NC(=O)c1cnn(-c2ccccn2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL7486 214097 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None Cc1cccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm950908d
CHEMBL3311030 209592 22 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
10579232 202041 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL 586 14 5 5 3.7 CSCC[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL6779 202041 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL 586 14 5 5 3.7 CSCC[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL415299 211434 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7181 214092 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
168278228 190486 0 None -3 2 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187530 190486 0 None -3 2 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
155517009 169588 0 None 3 2 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4444320 169588 0 None 3 2 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
168279295 190452 0 None -91 2 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187135 190452 0 None -91 2 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
155524563 170358 0 None -1 2 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 435 9 3 4 3.2 COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4455225 170358 0 None -1 2 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 435 9 3 4 3.2 COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
57403416 67952 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 508 6 2 5 5.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C(F)(F)F)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916284 67952 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 508 6 2 5 5.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C(F)(F)F)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
54752118 67955 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 483 6 2 6 4.2 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
CHEMBL1916288 67955 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 483 6 2 6 4.2 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
54752118 67955 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 483 6 2 6 4.2 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.10.090
CHEMBL1916288 67955 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 483 6 2 6 4.2 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.10.090
CHEMBL1770296 207136 26 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL None None None CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2011.03.049
57401370 69245 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 450 8 2 6 3.7 COCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934416 69245 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 450 8 2 6 3.7 COCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
4652862 47253 11 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 331 6 2 3 4.1 CSCCC(NC(=O)C1CCCCC1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1545798 47253 11 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 331 6 2 3 4.1 CSCCC(NC(=O)C1CCCCC1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
54587661 61083 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 386 5 3 3 4.0 O=C(NC(C(=O)NC1CCCCC1)c1ccc(Cl)cc1)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770304 61083 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 386 5 3 3 4.0 O=C(NC(C(=O)NC1CCCCC1)c1ccc(Cl)cc1)c1ccccc1O 10.1016/j.bmcl.2011.03.049
54586640 61084 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 460 5 3 4 4.3 Cc1cccc(C)c1NC(=O)C(NC(=O)c1nc2ccccc2[nH]c1=O)c1ccc(Cl)cc1 10.1016/j.bmcl.2011.03.049
CHEMBL1770307 61084 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 460 5 3 4 4.3 Cc1cccc(C)c1NC(=O)C(NC(=O)c1nc2ccccc2[nH]c1=O)c1ccc(Cl)cc1 10.1016/j.bmcl.2011.03.049
3825824 61145 12 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 415 8 1 4 5.3 CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2011.03.049
CHEMBL1770474 61145 12 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 415 8 1 4 5.3 CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2011.03.049
57403176 69227 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 406 8 2 5 3.8 CCC(CC)NC(=O)c1c(C)nn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934266 69227 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 406 8 2 5 3.8 CCC(CC)NC(=O)c1c(C)nn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
53233899 1384 0 None -69 2 Mouse 4.6 pIC50 = 4.6 Functional
Antagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5830 1384 0 None -69 2 Mouse 4.6 pIC50 = 4.6 Functional
Antagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770298 1384 0 None -69 2 Mouse 4.6 pIC50 = 4.6 Functional
Antagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
155529906 170906 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 421 8 3 4 2.8 COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C 10.1039/C9MD00336C
CHEMBL4463562 170906 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 421 8 3 4 2.8 COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C 10.1039/C9MD00336C
168280238 190360 0 None -6 2 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185921 190360 0 None -6 2 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
155510570 173459 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 449 10 3 4 3.1 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C 10.1039/C9MD00336C
CHEMBL4543372 173459 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 449 10 3 4 3.1 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C 10.1039/C9MD00336C
56949822 69253 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 490 7 2 6 4.6 CO[C@H]1CC[C@@H](n2nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c2NS(=O)(=O)c2ccc(C)cc2)CC1 10.1016/j.bmcl.2011.10.090
CHEMBL1934424 69253 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 490 7 2 6 4.6 CO[C@H]1CC[C@@H](n2nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c2NS(=O)(=O)c2ccc(C)cc2)CC1 10.1016/j.bmcl.2011.10.090
9988173 161367 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL 862 21 7 6 5.5 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL415296 161367 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL 862 21 7 6 5.5 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL266448 208939 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7214 214093 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
168278342 190557 0 None 1 2 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5188537 190557 0 None 1 2 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
57390867 69244 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 460 6 2 5 5.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCCC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934415 69244 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 460 6 2 5 5.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCCC2)cc1 10.1016/j.bmcl.2011.10.090
117993763 171038 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4465341 171038 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
57392882 67924 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 9 2 5 4.3 CCCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916255 67924 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 9 2 5 4.3 CCCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57394389 69246 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 464 9 2 6 4.1 COCCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934417 69246 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 464 9 2 6 4.1 COCCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
57396150 69251 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 462 6 2 6 3.8 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOCC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934422 69251 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 462 6 2 6 3.8 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOCC2)cc1 10.1016/j.bmcl.2011.10.090
53233899 1384 0 None 69 2 Human 6.5 pIC50 = 6.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5830 1384 0 None 69 2 Human 6.5 pIC50 = 6.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770298 1384 0 None 69 2 Human 6.5 pIC50 = 6.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
3939767 61146 2 None - 1 Human 6.5 pIC50 = 6.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 440 8 1 5 5.2 CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccc(C#N)cc1 10.1016/j.bmcl.2011.03.049
CHEMBL1770475 61146 2 None - 1 Human 6.5 pIC50 = 6.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 440 8 1 5 5.2 CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccc(C#N)cc1 10.1016/j.bmcl.2011.03.049
4329947 2465 1 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
5829 2465 1 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
CHEMBL1770297 2465 1 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
57398257 67943 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 466 6 1 5 4.7 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916275 67943 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 466 6 1 5 4.7 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57392729 69230 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 460 6 2 5 4.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2CC(F)(F)F)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934269 69230 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 460 6 2 5 4.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2CC(F)(F)F)cc1 10.1016/j.bmcl.2011.10.090
57399614 69250 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 543 7 2 6 4.7 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCN(CC(F)(F)F)CC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934421 69250 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 543 7 2 6 4.7 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCN(CC(F)(F)F)CC2)cc1 10.1016/j.bmcl.2011.10.090
54584753 61148 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 424 8 2 6 4.6 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
CHEMBL1770477 61148 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 424 8 2 6 4.6 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
155523344 170174 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 3.7 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1 10.1039/C9MD00336C
CHEMBL4452346 170174 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 3.7 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1 10.1039/C9MD00336C
168283359 190218 0 None -5 2 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5183856 190218 0 None -5 2 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
164916034 191094 0 None -6 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5196771 191094 0 None -6 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
155517073 169595 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4444413 169595 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
57396149 69247 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 478 6 2 6 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCSCC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934418 69247 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 478 6 2 6 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCSCC2)cc1 10.1016/j.bmcl.2011.10.090
53233899 1384 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5830 1384 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770298 1384 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
53233899 1384 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5830 1384 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770298 1384 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
53233899 1384 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.08.085
5830 1384 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.08.085
CHEMBL1770298 1384 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.08.085
57396214 69232 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 448 8 2 5 4.8 CCC(CC)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934271 69232 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 448 8 2 5 4.8 CCC(CC)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
57392871 67906 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 438 6 2 5 4.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916084 67906 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 438 6 2 5 4.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57394609 67929 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 427 8 2 6 3.3 CCC(CC)NC(=O)c1nnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916261 67929 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 427 8 2 6 3.3 CCC(CC)NC(=O)c1nnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
4881668 61086 7 None - 1 Human 5.4 pIC50 = 5.4 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 379 6 2 4 4.8 CSCCC(NC(=O)c1oc2ccccc2c1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770309 61086 7 None - 1 Human 5.4 pIC50 = 5.4 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 379 6 2 4 4.8 CSCCC(NC(=O)c1oc2ccccc2c1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
47012371 61088 6 None - 1 Human 5.4 pIC50 = 5.4 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 329 6 2 4 3.7 CSCCC(NC(=O)c1occc1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770310 61088 6 None - 1 Human 5.4 pIC50 = 5.4 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 329 6 2 4 3.7 CSCCC(NC(=O)c1occc1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
54584752 61140 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 341 6 3 4 3.5 CSCCC(NC(=O)c1ccccc1O)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770468 61140 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 341 6 3 4 3.5 CSCCC(NC(=O)c1ccccc1O)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL268823 209023 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)NCC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
168273654 189732 0 None -6 2 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5176452 189732 0 None -6 2 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
102234371 112505 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 889 22 6 8 6.0 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311137 112505 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 889 22 6 8 6.0 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
168283383 190250 0 None -3 2 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184396 190250 0 None -3 2 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
71697968 173999 17 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4556626 173999 17 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL162488 207067 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)Nc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7122 214091 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7034 214090 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)NC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
4329947 2465 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
5829 2465 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
CHEMBL1770297 2465 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
4329947 2465 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.08.085
5829 2465 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.08.085
CHEMBL1770297 2465 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.08.085
57401682 67940 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 8 2 5 4.2 CCC(CC)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916272 67940 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 8 2 5 4.2 CCC(CC)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57396468 67951 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916283 67951 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
4329947 2465 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
5829 2465 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
CHEMBL1770297 2465 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
5322194 1835 10 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 376 3 1 5 2.3 CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C 10.1016/j.bmcl.2011.03.049
5827 1835 10 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 376 3 1 5 2.3 CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C 10.1016/j.bmcl.2011.03.049
CHEMBL1770295 1835 10 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 376 3 1 5 2.3 CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C 10.1016/j.bmcl.2011.03.049
57398165 67927 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 412 8 2 5 3.6 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916259 67927 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 412 8 2 5 3.6 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2011.08.085
57398166 67928 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 404 8 2 5 3.5 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)C1CCCC1 10.1016/j.bmcl.2011.08.085
CHEMBL1916260 67928 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 404 8 2 5 3.5 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)C1CCCC1 10.1016/j.bmcl.2011.08.085
57398253 67935 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 9 2 5 4.0 CCC(CC)NC(=O)c1cnn(Cc2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916267 67935 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 9 2 5 4.0 CCC(CC)NC(=O)c1cnn(Cc2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57398255 67938 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 479 9 2 7 4.2 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916270 67938 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 479 9 2 7 4.2 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1 10.1016/j.bmcl.2011.08.085
57392964 67946 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 6 3.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916278 67946 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 6 3.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
54581782 61082 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 380 5 3 3 4.2 O=C(NC(C(=O)Nc1ccccc1)c1ccc(Cl)cc1)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770303 61082 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 380 5 3 3 4.2 O=C(NC(C(=O)Nc1ccccc1)c1ccc(Cl)cc1)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5157579 61139 19 None - 1 Human 5.3 pIC50 = 5.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 325 6 2 3 3.8 CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770466 61139 19 None - 1 Human 5.3 pIC50 = 5.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 325 6 2 3 3.8 CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
54581827 61149 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 425 8 2 7 4.0 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncncc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
CHEMBL1770478 61149 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 425 8 2 7 4.0 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncncc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
155523344 170174 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 3.7 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1 10.1039/C9MD00336C
CHEMBL4452346 170174 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 3.7 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1 10.1039/C9MD00336C
155517009 169588 0 None 3 2 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4444320 169588 0 None 3 2 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL7226 214094 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)NCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7363 214096 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CCCCNC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
54580796 61151 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 409 7 2 5 4.9 CCOc1ccc2oc(C(=O)N[C@H](CSC)c3nc4ccccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
CHEMBL1770481 61151 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 409 7 2 5 4.9 CCOc1ccc2oc(C(=O)N[C@H](CSC)c3nc4ccccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
57391103 67926 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1C 10.1016/j.bmcl.2011.08.085
CHEMBL1916258 67926 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1C 10.1016/j.bmcl.2011.08.085
57398256 67941 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 412 6 2 5 3.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916273 67941 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 412 6 2 5 3.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57401427 69229 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 406 6 2 5 3.5 CCn1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934268 69229 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 406 6 2 5 3.5 CCn1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
54587699 61150 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 391 7 2 4 5.0 CSCCC(NC(=O)c1sccc1Cl)c1ncc(-c2ccccc2)[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770479 61150 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 391 7 2 4 5.0 CSCCC(NC(=O)c1sccc1Cl)c1ncc(-c2ccccc2)[nH]1 10.1016/j.bmcl.2011.03.049
71698276 173227 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 4.1 COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4538076 173227 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 4.1 COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
57401681 67939 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 519 8 1 7 5.1 CCN(C(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1)C1CCCCC1 10.1016/j.bmcl.2011.08.085
CHEMBL1916271 67939 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 519 8 1 7 5.1 CCN(C(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1)C1CCCCC1 10.1016/j.bmcl.2011.08.085
57394707 67950 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916282 67950 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57394707 67950 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1916282 67950 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.10.090
57401369 69243 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 446 6 2 5 4.6 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934414 69243 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 446 6 2 5 4.6 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCC2)cc1 10.1016/j.bmcl.2011.10.090
54581780 61079 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 402 5 3 3 4.7 Cc1cccc(C(NC(=O)c2ccccc2O)C(=O)Nc2c(C)cccc2C)c1C 10.1016/j.bmcl.2011.03.049
CHEMBL1770300 61079 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 402 5 3 3 4.7 Cc1cccc(C(NC(=O)c2ccccc2O)C(=O)Nc2c(C)cccc2C)c1C 10.1016/j.bmcl.2011.03.049
57399797 67909 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 474 7 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccc(C)cc3C)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916087 67909 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 474 7 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccc(C)cc3C)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57401683 67942 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 452 6 2 5 4.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916274 67942 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 452 6 2 5 4.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
4654636 61078 8 None - 1 Human 6.1 pIC50 = 6.1 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 408 5 3 3 4.8 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccc(Cl)cc1 10.1016/j.bmcl.2011.03.049
CHEMBL1770299 61078 8 None - 1 Human 6.1 pIC50 = 6.1 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 408 5 3 3 4.8 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccc(Cl)cc1 10.1016/j.bmcl.2011.03.049
54582743 61081 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 380 5 3 3 4.3 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)C1CCCCC1 10.1016/j.bmcl.2011.03.049
CHEMBL1770302 61081 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 380 5 3 3 4.3 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)C1CCCCC1 10.1016/j.bmcl.2011.03.049
118707023 112499 0 None - 0 Human 7.0 pKd = 7 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 781 20 6 8 4.3 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](COC(C)(C)C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311130 112499 0 None - 0 Human 7.0 pKd = 7 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 781 20 6 8 4.3 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](COC(C)(C)C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311298 209613 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1016/j.bmc.2014.06.048
54752118 67955 0 None - 1 Human 6.9 pKd = 6.9 Functional
Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level
ChEMBL 483 6 2 6 4.2 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
CHEMBL1916288 67955 0 None - 1 Human 6.9 pKd = 6.9 Functional
Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level
ChEMBL 483 6 2 6 4.2 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
CHEMBL3311144 209603 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311292 209607 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311294 209609 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C(=O)O)[C@@H](C)OC(C)(C)C 10.1016/j.bmc.2014.06.048
118706970 112496 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 795 20 6 8 4.7 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311037 112496 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 795 20 6 8 4.7 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
118707032 112507 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 870 24 7 8 5.1 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)c1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311140 112507 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 870 24 7 8 5.1 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)c1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
118707031 112506 0 None - 0 Human 6.8 pKd = 6.8 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 877 24 7 8 5.3 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)C1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311139 112506 0 None - 0 Human 6.8 pKd = 6.8 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 877 24 7 8 5.3 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)C1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311291 209606 0 None - 0 Human 6.8 pKd = 6.8 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 met