Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL1651721 lshr_human Human No 9.0 EC50 = 1 nM Funct
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
482 7 4 8 3.4 C#CCNC(=O)CNc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1
CHEMBL1651723 lshr_human Human No 8.0 EC50 = 10 nM Funct
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
1136 18 5 17 10.1 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL211871 lshr_human Human No 6.0 EC50 = 1100 nM Funct
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
403 4 1 8 4.6 COc1cccc(-c2nc(SC)nc3sc(C(=O)OC(C)(C)C)c(N)c23)c1
CHEMBL212815 lshr_human Human No 5.9 EC50 = 1200 nM Funct
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
390 3 2 6 4.3 CSc1nc(-c2cccc(F)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL269261 lshr_human Human No 4.9 EC50 = 12100 nM Funct
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
610 13 3 7 6.2 CC(C)(C)Oc1ccc(C[C@H](NC(=O)CCCCNc2cc(-c3cccnc3)nn2-c2ccc(C(C)(C)C)cc2)C(N)=O)cc1
CHEMBL439392 lshr_human Human No 6.8 EC50 = 150 nM Funct
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
568 13 4 7 5.1 CC(C)(C)c1ccc(-n2nc(-c3ccccn3)cc2NCCCCCC(=O)N[C@@H](Cc2cccc(O)c2)C(N)=O)cc1
CHEMBL211129 lshr_human Human No 5.8 EC50 = 1500 nM Funct
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
420 4 2 7 4.3 COc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1F
CHEMBL474041 lshr_human Human Yes 5.8 EC50 = 1600 nM Funct
Agonist activity at human luteinizing hormone receptor expressed in CHOK1 cells assessed as c-AMP-mediated luciferase productionAgonist activity at human luteinizing hormone receptor expressed in CHOK1 cells assessed as c-AMP-mediated luciferase production
357 4 1 2 6.1 O=C(NC1CCCC1)Oc1cc(-c2ccccc2)cc(-c2ccccc2)c1
CHEMBL247700 lshr_human Human No 6.8 EC50 = 170 nM Funct
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
554 12 4 7 5.3 CC(C)(C)c1ccc(-n2nc(-c3ccccn3)cc2NCCCCCC(=O)N[C@H](C(N)=O)c2ccc(O)cc2)cc1
CHEMBL393847 lshr_human Human No 6.7 EC50 = 190 nM Funct
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
537 12 2 5 5.5 CC(C)(C)c1ccc(-n2nc(-c3ccncc3)cc2CCCCC(=O)N[C@H](CC(N)=O)Cc2ccccc2)cc1
CHEMBL378091 lshr_human Human No 5.7 EC50 = 1900 nM Funct
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
388 3 3 7 3.9 CSc1nc(-c2cccc(O)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL246321 lshr_human Human No 7.7 EC50 = 20 nM Funct
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
539 11 3 6 4.9 CC(C)(C)c1ccc(-n2nc(-c3cccnc3)cc2CCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)cc1
CHEMBL211405 lshr_human Human Yes 6.7 EC50 = 220 nM Bind
Agonist activity at LHCGR (unknown origin)Agonist activity at LHCGR (unknown origin)
402 4 2 7 4.2 COc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1
CHEMBL245663 lshr_human Human No 5.6 EC50 = 2300 nM Funct
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
539 11 3 6 4.9 CC(C)(C)c1ccc(-n2nc(CCCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)cc2-c2ccncc2)cc1
CHEMBL1651829 lshr_human Human No 7.6 EC50 = 24 nM Funct
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
1136 18 5 17 10.1 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL397316 lshr_human Human No 6.6 EC50 = 250 nM Funct
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
539 11 3 6 4.9 CC(C)(C)c1ccc(-n2nc(-c3ccncc3)cc2CCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)cc1
CHEMBL1651823 lshr_human Human No 7.6 EC50 = 27 nM Funct
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
1180 21 5 18 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL211405 lshr_human Human Yes 6.5 EC50 = 300 nM Funct
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
402 4 2 7 4.2 COc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1
CHEMBL1651831 lshr_human Human No 7.4 EC50 = 39 nM Funct
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
1313 30 5 21 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL1651824 lshr_human Human No 7.4 EC50 = 43 nM Funct
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
1225 24 5 19 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL1651828 lshr_human Human No 8.3 EC50 = 5 nM Funct
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
682 17 4 14 3.9 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCN=[N+]=[N-])nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL247945 lshr_human Human No 6.3 EC50 = 500 nM Funct
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
609 8 3 6 6.6 CC(C)(C)c1ccc(-n2nc(-c3cc4ccccc4cn3)cc2-c2cccc(C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)c2)cc1
CHEMBL1651826 lshr_human Human No 7.3 EC50 = 55 nM Funct
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
1313 30 5 21 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL1651822 lshr_human Human No 7.2 EC50 = 57 nM Funct
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
1269 27 5 20 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL1651825 lshr_human Human No 7.2 EC50 = 61 nM Funct
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
1269 27 5 20 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL1651821 lshr_human Human No 7.1 EC50 = 75 nM Funct
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
1225 24 5 19 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL429108 lshr_human Human No 7.1 EC50 = 80 nM Funct
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
496 10 2 5 6.0 CC(C)(C)c1ccc(-n2nc(-c3cccnc3)cc2CCCCC(=O)NCCc2ccc(O)cc2)cc1
CHEMBL1651830 lshr_human Human No 7.1 EC50 = 80 nM Funct
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
1180 21 5 18 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1
CHEMBL377399 lshr_human Human No 6.1 EC50 = 800 nM Funct
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
416 4 1 7 4.5 COc1cccc(-c2nc(SC)nc3sc(C(=O)N(C)C(C)(C)C)c(N)c23)c1
CHEMBL377769 lshr_human Human No 6.1 EC50 = 800 nM Funct
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
432 5 2 8 4.2 COc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1OC
CHEMBL4587440 lshr_human Human No 7.0 IC50 = 102 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
457 4 1 3 6.3 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1
CHEMBL4573509 lshr_human Human No 7.0 IC50 = 107 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
398 3 1 3 5.6 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2ccc(Cl)cc2)cc1
CHEMBL4537998 lshr_human Human Yes 5.9 IC50 = 1200 nM Bind
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 4 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 4 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1
CHEMBL4531781 lshr_human Human No 6.9 IC50 = 127 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
478 4 1 3 7.5 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2sccc2C1c1ccc(Cl)cc1
CHEMBL4537998 lshr_human Human Yes 5.8 IC50 = 1500 nM Bind
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 10 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 10 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1
CHEMBL4537998 lshr_human Human Yes 5.8 IC50 = 1500 nM Bind
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1
CHEMBL4560733 lshr_human Human No 5.8 IC50 = 1620 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
402 2 1 2 6.2 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccccc1
CHEMBL4456365 lshr_human Human No 5.8 IC50 = 1680 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
425 4 2 4 4.2 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2ccc(F)c(C(N)=O)c2)cc1
CHEMBL4537998 lshr_human Human Yes 5.8 IC50 = 1700 nM Bind
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 16 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 16 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1
CHEMBL4443605 lshr_human Human No 6.8 IC50 = 174 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
420 2 1 2 6.4 O=C(Nc1ccc(F)c(Cl)c1)N1CCc2sccc2C1c1ccc(Cl)cc1
CHEMBL4458424 lshr_human Human Yes 6.7 IC50 = 185 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
459 4 1 5 5.1 O=C(Nc1cnc(Oc2ccc(F)cc2)nc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1
CHEMBL4464604 lshr_human Human No 5.7 IC50 = 1850 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
438 2 1 2 6.5 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccc(F)c(F)c1
CHEMBL4461980 lshr_human Human No 6.7 IC50 = 193 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
394 4 1 4 4.9 COc1cc(NC(=O)N2CCc3sccc3[C@@H]2c2ccccc2)cc(OC)c1
CHEMBL4537998 lshr_human Human Yes 6.7 IC50 = 200 nM Bind
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 4 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 4 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1
CHEMBL4522381 lshr_human Human No 6.7 IC50 = 207 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
424 5 1 5 5.0 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(OC)cc(OC)c2)cc1
CHEMBL4593222 lshr_rat Rat Yes 6.7 IC50 = 212 nM Funct
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
432 3 1 3 6.2 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1
CHEMBL4537998 lshr_human Human Yes 5.7 IC50 = 2200 nM Bind
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 10 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 10 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1
CHEMBL4537998 lshr_human Human Yes 5.7 IC50 = 2200 nM Bind
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 16 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 16 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1
CHEMBL4537998 lshr_rat Rat Yes 7.6 IC50 = 23 nM Funct
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1
CHEMBL474041 lshr_human Human Yes 5.6 IC50 = 2300 nM Bind
Displacement of [3H]Org43553 from human luteinizing hormone receptor expressed in CHOK1 cellsDisplacement of [3H]Org43553 from human luteinizing hormone receptor expressed in CHOK1 cells
357 4 1 2 6.1 O=C(NC1CCCC1)Oc1cc(-c2ccccc2)cc(-c2ccccc2)c1
CHEMBL4551301 lshr_human Human No 5.6 IC50 = 2310 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
419 2 2 3 4.9 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccc(=O)[nH]c1
CHEMBL4537998 lshr_human Human Yes 5.6 IC50 = 2500 nM Bind
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1
CHEMBL4468163 lshr_human Human No 5.6 IC50 = 2610 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
416 2 1 2 6.5 Cc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1
CHEMBL4581889 lshr_human Human No 6.6 IC50 = 275 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
398 3 1 3 5.6 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cccc(Cl)c2)cc1
CHEMBL4555151 lshr_human Human No 6.5 IC50 = 312 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
458 4 1 4 5.7 O=C(Nc1ccc(Oc2ccc(F)cc2)nc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1
CHEMBL4588196 lshr_human Human No 5.5 IC50 = 3130 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
420 2 1 2 6.4 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1cccc(F)c1
CHEMBL4570127 lshr_human Human No 5.5 IC50 = 3240 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
420 2 1 2 6.4 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccccc1F
CHEMBL4579421 lshr_human Human No 6.5 IC50 = 332 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
460 4 1 3 7.4 O=C(Nc1cccc(Oc2ccccc2)c1)N1CCc2sccc2C1c1ccc(Cl)cc1
CHEMBL4471875 lshr_human Human No 5.5 IC50 = 3320 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
440 5 1 5 5.1 COc1ccc(C2c3ccsc3CCN2C(=S)Nc2cc(OC)cc(OC)c2)cc1
CHEMBL4468307 lshr_human Human No 5.4 IC50 = 3650 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
470 2 1 2 7.3 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccc(C(F)(F)F)cc1
CHEMBL4593222 lshr_human Human Yes 6.4 IC50 = 378 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
432 3 1 3 6.2 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1
CHEMBL4471621 lshr_human Human No 6.4 IC50 = 403 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
432 3 1 3 6.2 COc1ccc([C@H]2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1
CHEMBL4471621 lshr_rat Rat No 6.4 IC50 = 412 nM Funct
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
432 3 1 3 6.2 COc1ccc([C@H]2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1
CHEMBL4458424 lshr_rat Rat Yes 7.3 IC50 = 46 nM Funct
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
459 4 1 5 5.1 O=C(Nc1cnc(Oc2ccc(F)cc2)nc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1
CHEMBL4590976 lshr_human Human No 6.3 IC50 = 486 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
436 2 1 2 6.9 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccc(Cl)cc1
CHEMBL4449797 lshr_rat Rat No 5.3 IC50 = 4890 nM Funct
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
432 3 1 3 6.2 COc1ccc([C@@H]2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1
CHEMBL4573451 lshr_human Human No 5.3 IC50 = 5180 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
403 2 1 3 5.6 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccncc1
CHEMBL4580951 lshr_human Human No 6.2 IC50 = 580 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
392 3 1 3 5.6 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(C)cc(C)c2)cc1
CHEMBL4537998 lshr_human Human Yes 6.2 IC50 = 650 nM Bind
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 1 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 1 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1
CHEMBL4449797 lshr_human Human No 5.2 IC50 = 6790 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
432 3 1 3 6.2 COc1ccc([C@@H]2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1
CHEMBL4471103 lshr_human Human No 5.1 IC50 = 7470 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
403 2 1 3 5.6 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1cccnc1
CHEMBL4460075 lshr_human Human No 7.1 IC50 = 81 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
470 3 1 3 6.6 O=C(Nc1ccc(F)c(OC(F)(F)F)c1)N1CCc2sccc2C1c1ccc(Cl)cc1
CHEMBL2032175 lshr_human Human No 7.0 IC50 = 95 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
368 2 1 2 5.6 O=C(Nc1ccccc1)N1CCc2sccc2C1c1ccc(Cl)cc1
CHEMBL4537998 lshr_human Human Yes 7.0 IC50 = 96 nM Funct
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1
CHEMBL4537998 lshr_human Human Yes 7.0 IC50 = 97 nM Bind
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 1 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 1 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1
CHEMBL275935 lshr_rat Rat No 9.9 Kd = 0.1 nM Bind
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cellsIn vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
967 10 1 14 7.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C3CCCC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C
CHEMBL412984 lshr_rat Rat No 9.4 Kd = 0.4 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
None None None CC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
CHEMBL12282 lshr_rat Rat No 9.3 Kd = 0.5 nM Bind
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cellsIn vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
937 11 1 14 6.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(F)c(Cl)c3)C(=O)O[C@]12C
CHEMBL216617 lshr_rat Rat No 9.3 Kd = 0.6 nM Funct
Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
1041 26 10 10 2.8 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12
CHEMBL303274 lshr_rat Rat No 8.8 Kd = 1.7 nM Bind
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cellsIn vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
953 11 1 14 7.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C
CHEMBL273440 lshr_rat Rat No 8.8 Kd = 1.8 nM Bind
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cellsIn vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
941 10 1 14 7.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C
CHEMBL275694 lshr_rat Rat No 8.7 Kd = 1.8 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
1030 26 11 10 2.1 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12
CHEMBL415109 lshr_rat Rat No 8.0 Kd = 10.5 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
1067 28 9 10 3.4 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12
CHEMBL412573 lshr_rat Rat No 7.9 Kd = 12.9 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
1032 26 11 11 1.5 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)COc1cccc2ccccc12
CHEMBL2369800 lshr_rat Rat No 7.8 Kd = 14.8 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
977 25 10 10 1.2 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12
CHEMBL2369798 lshr_rat Rat No 7.8 Kd = 15.9 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1ccc2ccccc2c1
CHEMBL2369791 lshr_rat Rat No 6.7 Kd = 190.6 nM Funct
In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
918 24 11 10 0.4 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)c1c[nH]c2ccccc12
CHEMBL2369809 lshr_rat Rat No 5.7 Kd = 1905.5 nM Funct
In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
906 25 10 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1cccnc1
CHEMBL2369810 lshr_rat Rat No 6.7 Kd = 204.2 nM Funct
In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
955 25 10 10 1.5 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1cccc2ccccc12
CHEMBL429543 lshr_rat Rat No 7.6 Kd = 25.1 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
1030 26 11 10 2.1 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12
CHEMBL2369813 lshr_rat Rat No 6.6 Kd = 251.2 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
957 26 10 10 1.4 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12
CHEMBL2369790 lshr_rat Rat No 5.6 Kd = 2754.2 nM Funct
In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
932 25 11 10 0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1c[nH]c2ccccc12
CHEMBL264298 lshr_rat Rat No 8.5 Kd = 3.0 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
1106 28 10 10 3.9 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12
CHEMBL265413 lshr_rat Rat No 8.5 Kd = 3.2 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
1024 25 11 10 1.9 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CC12CC3CC(CC(C3)C1)C2
CHEMBL274609 lshr_rat Rat No 8.4 Kd = 3.6 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
1117 28 9 10 4.6 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12
CHEMBL411175 lshr_rat Rat No 7.5 Kd = 32.4 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
1033 28 9 10 3.2 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12
CHEMBL2369793 lshr_rat Rat No 6.5 Kd = 346.7 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1ccc(OC)cc1
CHEMBL2369808 lshr_rat Rat No 6.4 Kd = 363.1 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
986 26 11 10 1.7 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12
CHEMBL275709 lshr_rat Rat No 8.2 Kd = 6.3 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
1027 25 10 10 2.4 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12
CHEMBL2369807 lshr_rat Rat No 8.2 Kd = 6.6 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12
CHEMBL2369787 lshr_rat Rat No 7.2 Kd = 60.3 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C\c1ccc(OC)cc1
CHEMBL386525 lshr_rat Rat No 7.1 Kd = 79.4 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
1120 29 10 10 4.3 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)CCc1cccc2ccccc12
CHEMBL413887 lshr_rat Rat No 8.1 Kd = 8.5 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
1044 27 11 10 2.5 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCCc1c[nH]c2ccccc12
CHEMBL2369799 lshr_rat Rat No 6.1 Kd = 831.8 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
983 25 10 10 1.9 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12
CHEMBL2369806 lshr_rat Rat No 6.1 Kd = 851.1 nM Funct
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
980 26 11 10 0.9 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12
CHEMBL412984 lshr_rat Rat No 10.7 Ki = 0.0 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
None None None CC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
CHEMBL407606 lshr_rat Rat No 10.6 Ki = 0.0 nM Bind
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
1292 32 15 13 0.5 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1
CHEMBL407123 lshr_rat Rat No 10.4 Ki = 0.0 nM Bind
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(=O)O
CHEMBL405737 lshr_rat Rat No 10.1 Ki = 0.1 nM Bind
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
1296 32 15 14 -0.4 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1
CHEMBL385042 lshr_rat Rat No 10.0 Ki = 0.1 nM Bind
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
1220 32 14 14 -0.8 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1
CHEMBL415571 lshr_rat Rat No 9.8 Ki = 0.2 nM Bind
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
1200 33 14 15 -1.9 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1
CHEMBL385468 lshr_rat Rat No 9.7 Ki = 0.2 nM Bind
Negative logarithm of equilibrium dissociation constant in the rat pituitary Luteinizing Hormone Releasing Hormone (LHRH) receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary Luteinizing Hormone Releasing Hormone (LHRH) receptor binding assay
1209 32 15 14 -1.4 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1
CHEMBL429240 lshr_rat Rat No 9.7 Ki = 0.2 nM Bind
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
1306 32 14 13 0.9 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCC(=O)N1
CHEMBL216617 lshr_rat Rat No 9.6 Ki = 0.3 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1041 26 10 10 2.8 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12
CHEMBL246321 lshr_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [125I]hCG from LH receptorDisplacement of [125I]hCG from LH receptor
539 11 3 6 4.9 CC(C)(C)c1ccc(-n2nc(-c3cccnc3)cc2CCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)cc1
CHEMBL437798 lshr_rat Rat No 9.4 Ki = 0.4 nM Bind
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
1298 33 14 14 -0.2 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(C)C(C)=O
CHEMBL265413 lshr_rat Rat No 9.3 Ki = 0.5 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1024 25 11 10 1.9 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CC12CC3CC(CC(C3)C1)C2
CHEMBL275694 lshr_rat Rat No 9.3 Ki = 0.5 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1030 26 11 10 2.1 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12
CHEMBL264298 lshr_rat Rat No 8.9 Ki = 1.2 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1106 28 10 10 3.9 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12
CHEMBL1007 lshr_rat Rat Yes 8.9 Ki = 1.3 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O
CHEMBL413887 lshr_rat Rat No 8.9 Ki = 1.4 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1044 27 11 10 2.5 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCCc1c[nH]c2ccccc12
CHEMBL2369787 lshr_rat Rat No 8.9 Ki = 1.4 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C\c1ccc(OC)cc1
CHEMBL266205 lshr_rat Rat No 8.9 Ki = 1.4 nM Bind
Negative logarithm of equilibrium dissociation constant in the rat pituitary Luteinizing Hormone Releasing Hormone (LHRH) receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary Luteinizing Hormone Releasing Hormone (LHRH) receptor binding assay
1223 32 14 14 -1.1 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1
CHEMBL429543 lshr_rat Rat No 8.8 Ki = 1.7 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1030 26 11 10 2.1 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12
CHEMBL412573 lshr_rat Rat No 8.7 Ki = 1.9 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1032 26 11 11 1.5 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)COc1cccc2ccccc12
CHEMBL2369780 lshr_rat Rat No 6.9 Ki = 123.0 nM Bind
In vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constant
960 27 11 10 1.1 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCCc1c[nH]c2ccccc12
CHEMBL2369790 lshr_rat Rat No 5.9 Ki = 1349.0 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
932 25 11 10 0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1c[nH]c2ccccc12
CHEMBL2369809 lshr_rat Rat No 5.8 Ki = 1479.1 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
906 25 10 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1cccnc1
CHEMBL2369793 lshr_rat Rat No 6.8 Ki = 158.5 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1ccc(OC)cc1
CHEMBL2369806 lshr_rat Rat No 7.8 Ki = 16.6 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
980 26 11 10 0.9 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12
CHEMBL2369783 lshr_rat Rat No 5.8 Ki = 1621.8 nM Bind
In vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constant
908 26 10 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccnc1
CHEMBL411175 lshr_rat Rat No 7.7 Ki = 20.0 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1033 28 9 10 3.2 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12
CHEMBL2369784 lshr_rat Rat No 6.7 Ki = 195.0 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
946 26 11 10 0.7 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12
CHEMBL217405 lshr_rat Rat No 8.7 Ki = 2.2 nM Bind
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
1219 32 14 13 -0.2 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1
CHEMBL2369807 lshr_rat Rat No 8.7 Ki = 2.2 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12
CHEMBL274682 lshr_rat Rat No 8.6 Ki = 2.6 nM Bind
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
1211 33 14 14 -1.2 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(C)C(C)=O
CHEMBL275709 lshr_rat Rat No 8.6 Ki = 2.6 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1027 25 10 10 2.4 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12
CHEMBL2369791 lshr_rat Rat No 6.7 Ki = 204.2 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
918 24 11 10 0.4 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)c1c[nH]c2ccccc12
CHEMBL414382 lshr_rat Rat No 7.6 Ki = 22.9 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1047 29 9 10 3.6 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)CCc1cccc2ccccc12
CHEMBL2369813 lshr_rat Rat No 7.6 Ki = 25.1 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
957 26 10 10 1.4 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12
CHEMBL415109 lshr_rat Rat No 8.5 Ki = 3.5 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1067 28 9 10 3.4 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12
CHEMBL2369798 lshr_rat Rat No 8.4 Ki = 3.7 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1ccc2ccccc2c1
CHEMBL2369799 lshr_rat Rat No 7.4 Ki = 36.3 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
983 25 10 10 1.9 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12
CHEMBL274609 lshr_rat Rat No 7.4 Ki = 37.2 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1117 28 9 10 4.6 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12
CHEMBL2369788 lshr_rat Rat No 8.3 Ki = 4.6 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12
CHEMBL2369814 lshr_rat Rat No 8.3 Ki = 4.7 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12
CHEMBL2369808 lshr_rat Rat No 7.4 Ki = 41.7 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
986 26 11 10 1.7 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12
CHEMBL2369810 lshr_rat Rat No 7.3 Ki = 50.1 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
955 25 10 10 1.5 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1cccc2ccccc12
CHEMBL386525 lshr_rat Rat No 8.2 Ki = 6.3 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
1120 29 10 10 4.3 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)CCc1cccc2ccccc12
CHEMBL2369789 lshr_rat Rat No 7.2 Ki = 67.6 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
943 25 10 10 1.0 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12
CHEMBL2369781 lshr_rat Rat No 6.1 Ki = 758.6 nM Bind
In vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constant
929 24 10 10 1.1 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)c1cccc2ccccc12
CHEMBL2369794 lshr_rat Rat No 7.1 Ki = 85.1 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
961 26 12 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12
CHEMBL414071 lshr_rat Rat No 8.0 Ki = 9.3 nM Bind
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
1204 32 14 14 -1.3 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1
CHEMBL2369800 lshr_rat Rat No 8.0 Ki = 9.8 nM Bind
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
977 25 10 10 1.2 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12
CHEMBL1201419 lshr_human Human No 10.4 pIC50 = Funct
UnclassifiedUnclassified
None None None None