Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type

 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
11648468 133501 None 0 strain AD169 Functional pEC50 = 4.9 4.9 - 1
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 433 7 1 2 6.5 Cc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 10.1021/jm050418d
CHEMBL370577 133501 None 0 strain AD169 Functional pEC50 = 4.9 4.9 - 1
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 433 7 1 2 6.5 Cc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 10.1021/jm050418d
10410351 72380 None 0 strain AD169 Functional pEC50 = 4.9 4.9 - 1
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 428 7 0 2 6.8 N#CC(CCCN1CCC(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL198505 72380 None 0 strain AD169 Functional pEC50 = 4.9 4.9 - 1
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 428 7 0 2 6.8 N#CC(CCCN1CCC(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
10811537 71442 None 0 strain AD169 Functional pEC50 = 4.6 4.6 - 1
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 410 7 1 3 5.3 N#CC(CCCN1CCC(O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL195943 71442 None 0 strain AD169 Functional pEC50 = 4.6 4.6 - 1
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 410 7 1 3 5.3 N#CC(CCCN1CCC(O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
10670785 33128 None 0 strain AD169 Functional pEC50 = 4.5 4.5 - 1
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 440 8 1 4 5.3 COc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm050418d
CHEMBL141713 33128 None 0 strain AD169 Functional pEC50 = 4.5 4.5 - 1
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 440 8 1 4 5.3 COc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm050418d
9889700 118652 None 11 strain AD169 Functional pEC50 = 5.5 5.5 -11 4
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL34166 118652 None 11 strain AD169 Functional pEC50 = 5.5 5.5 -11 4
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
10526132 72502 None 0 strain AD169 Functional pEC50 = 5.4 5.4 1 2
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 419 7 1 2 6.2 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
CHEMBL142004 72502 None 0 strain AD169 Functional pEC50 = 5.4 5.4 1 2
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 419 7 1 2 6.2 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
CHEMBL198935 72502 None 0 strain AD169 Functional pEC50 = 5.4 5.4 1 2
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 419 7 1 2 6.2 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
11719018 72389 None 0 strain AD169 Functional pEC50 = 5.0 5.0 - 1
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 433 7 1 2 6.5 Cc1ccccc1C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm050418d
CHEMBL198553 72389 None 0 strain AD169 Functional pEC50 = 5.0 5.0 - 1
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 433 7 1 2 6.5 Cc1ccccc1C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm050418d


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
56679132 65188 None 0 strain AD169 Binding pEC50 = 6 6.0 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 281 3 1 2 3.0 CC1(CCO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL1824272 65188 None 0 strain AD169 Binding pEC50 = 6 6.0 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 281 3 1 2 3.0 CC1(CCO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
56679132 65188 None 0 strain AD169 Binding pEC50 = 6.0 6.0 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 281 3 1 2 3.0 CC1(CCO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL1824272 65188 None 0 strain AD169 Binding pEC50 = 6.0 6.0 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 281 3 1 2 3.0 CC1(CCO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
56668956 65186 None 0 strain AD169 Binding pEC50 = 5.8 5.8 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 415 13 1 3 4.3 CCCCCCCCCC(=O)N(CCN(C)C)CC1(C)Cc2ccccc2C(=O)N1 10.1016/j.bmcl.2014.06.082
CHEMBL1824269 65186 None 0 strain AD169 Binding pEC50 = 5.8 5.8 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 415 13 1 3 4.3 CCCCCCCCCC(=O)N(CCN(C)C)CC1(C)Cc2ccccc2C(=O)N1 10.1016/j.bmcl.2014.06.082
56668956 65186 None 0 strain AD169 Binding pEC50 = 5.8 5.8 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 415 13 1 3 4.3 CCCCCCCCCC(=O)N(CCN(C)C)CC1(C)Cc2ccccc2C(=O)N1 10.1016/j.bmcl.2014.06.082
CHEMBL1824269 65186 None 0 strain AD169 Binding pEC50 = 5.8 5.8 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 415 13 1 3 4.3 CCCCCCCCCC(=O)N(CCN(C)C)CC1(C)Cc2ccccc2C(=O)N1 10.1016/j.bmcl.2014.06.082
56682429 65189 None 0 strain AD169 Binding pEC50 = 5.5 5.5 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 413 6 0 3 4.4 CC1(COC(=O)Cc2ccccc2)Cc2ccccc2CN1C(=O)Cc1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL1824275 65189 None 0 strain AD169 Binding pEC50 = 5.5 5.5 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 413 6 0 3 4.4 CC1(COC(=O)Cc2ccccc2)Cc2ccccc2CN1C(=O)Cc1ccccc1 10.1016/j.bmcl.2014.06.082
56682429 65189 None 0 strain AD169 Binding pEC50 = 5.5 5.5 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 413 6 0 3 4.4 CC1(COC(=O)Cc2ccccc2)Cc2ccccc2CN1C(=O)Cc1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL1824275 65189 None 0 strain AD169 Binding pEC50 = 5.5 5.5 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 413 6 0 3 4.4 CC1(COC(=O)Cc2ccccc2)Cc2ccccc2CN1C(=O)Cc1ccccc1 10.1016/j.bmcl.2014.06.082
4106 2502 None 21 strain AD169 Binding pEC50 = 6.5 6.5 - 33
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
5358812 2502 None 21 strain AD169 Binding pEC50 = 6.5 6.5 - 33
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
89 2502 None 21 strain AD169 Binding pEC50 = 6.5 6.5 - 33
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
CHEMBL93240 2502 None 21 strain AD169 Binding pEC50 = 6.5 6.5 - 33
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
4106 2502 None 21 strain AD169 Binding pEC50 = 6.5 6.5 - 33
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
5358812 2502 None 21 strain AD169 Binding pEC50 = 6.5 6.5 - 33
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
89 2502 None 21 strain AD169 Binding pEC50 = 6.5 6.5 - 33
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
CHEMBL93240 2502 None 21 strain AD169 Binding pEC50 = 6.5 6.5 - 33
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
56665519 65187 None 0 strain AD169 Binding pEC50 = 5.4 5.4 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 267 2 1 2 2.6 CC1(CO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL1824270 65187 None 0 strain AD169 Binding pEC50 = 5.4 5.4 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 267 2 1 2 2.6 CC1(CO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
56665519 65187 None 0 strain AD169 Binding pEC50 = 5.4 5.4 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 267 2 1 2 2.6 CC1(CO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL1824270 65187 None 0 strain AD169 Binding pEC50 = 5.4 5.4 - 0
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 267 2 1 2 2.6 CC1(CO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
9889700 118652 None 11 strain AD169 Binding pEC50 = 5.4 5.4 - 1
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL34166 118652 None 11 strain AD169 Binding pEC50 = 5.4 5.4 - 1
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2014.06.082
9889700 118652 None 11 strain AD169 Binding pEC50 = 5.3 5.3 - 1
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL34166 118652 None 11 strain AD169 Binding pEC50 = 5.3 5.3 - 1
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2014.06.082
10410351 72380 None 0 strain AD169 Binding pIC50 = 5.0 5.0 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 428 7 0 2 6.8 N#CC(CCCN1CCC(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL198505 72380 None 0 strain AD169 Binding pIC50 = 5.0 5.0 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 428 7 0 2 6.8 N#CC(CCCN1CCC(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
11547305 141463 None 0 strain AD169 Binding pIC50 = 4.9 4.9 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 433 7 1 2 6.5 Cc1cccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)c1 10.1021/jm050418d
CHEMBL383822 141463 None 0 strain AD169 Binding pIC50 = 4.9 4.9 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 433 7 1 2 6.5 Cc1cccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)c1 10.1021/jm050418d
11609863 16853 None 0 strain AD169 Binding pIC50 = 4.8 4.8 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 343 6 1 2 4.6 OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccccc2)CC1 10.1021/jm050418d
CHEMBL124813 16853 None 0 strain AD169 Binding pIC50 = 4.8 4.8 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 343 6 1 2 4.6 OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccccc2)CC1 10.1021/jm050418d
11705066 72245 None 0 strain AD169 Binding pIC50 = 4.8 4.8 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 449 8 1 3 6.2 COc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 10.1021/jm050418d
CHEMBL198111 72245 None 0 strain AD169 Binding pIC50 = 4.8 4.8 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 449 8 1 3 6.2 COc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 10.1021/jm050418d
11569984 72330 None 0 strain AD169 Binding pIC50 = 4.8 4.8 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 487 7 1 2 7.5 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm050418d
CHEMBL198332 72330 None 0 strain AD169 Binding pIC50 = 4.8 4.8 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 487 7 1 2 7.5 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm050418d
11525302 72402 None 0 strain AD169 Binding pIC50 = 4.8 4.8 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 453 7 1 2 6.9 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/jm050418d
CHEMBL198614 72402 None 0 strain AD169 Binding pIC50 = 4.8 4.8 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 453 7 1 2 6.9 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/jm050418d
11642194 141232 None 0 strain AD169 Binding pIC50 = 4.8 4.8 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 487 7 1 2 7.5 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1 10.1021/jm050418d
CHEMBL382760 141232 None 0 strain AD169 Binding pIC50 = 4.8 4.8 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 487 7 1 2 7.5 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1 10.1021/jm050418d
10576989 72111 None 0 strain AD169 Binding pIC50 = 4.7 4.7 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 488 7 1 3 6.0 N#CC(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL197749 72111 None 0 strain AD169 Binding pIC50 = 4.7 4.7 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 488 7 1 3 6.0 N#CC(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
11648468 133501 None 0 strain AD169 Binding pIC50 = 4.5 4.5 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 433 7 1 2 6.5 Cc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 10.1021/jm050418d
CHEMBL370577 133501 None 0 strain AD169 Binding pIC50 = 4.5 4.5 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 433 7 1 2 6.5 Cc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 10.1021/jm050418d
11510165 72314 None 0 strain AD169 Binding pIC50 = 4.5 4.5 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 390 8 0 4 4.6 CCOC(=O)C1CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
CHEMBL198308 72314 None 0 strain AD169 Binding pIC50 = 4.5 4.5 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 390 8 0 4 4.6 CCOC(=O)C1CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
10811537 71442 None 0 strain AD169 Binding pIC50 = 4.5 4.5 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 410 7 1 3 5.3 N#CC(CCCN1CCC(O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL195943 71442 None 0 strain AD169 Binding pIC50 = 4.5 4.5 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 410 7 1 3 5.3 N#CC(CCCN1CCC(O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
11634351 72320 None 0 strain AD169 Binding pIC50 = 4.4 4.4 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 478 7 1 3 6.6 N#CC(CCCN1CCC(O)(c2ccc(Cl)c(Cl)c2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL198313 72320 None 0 strain AD169 Binding pIC50 = 4.4 4.4 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 478 7 1 3 6.6 N#CC(CCCN1CCC(O)(c2ccc(Cl)c(Cl)c2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
11584791 133626 None 0 strain AD169 Binding pIC50 = 4.3 4.3 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 512 7 1 3 6.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)c(C(F)(F)F)c2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL371031 133626 None 0 strain AD169 Binding pIC50 = 4.3 4.3 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 512 7 1 3 6.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)c(C(F)(F)F)c2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
11719018 72389 None 0 strain AD169 Binding pIC50 = 5.3 5.3 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 433 7 1 2 6.5 Cc1ccccc1C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm050418d
CHEMBL198553 72389 None 0 strain AD169 Binding pIC50 = 5.3 5.3 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 433 7 1 2 6.5 Cc1ccccc1C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm050418d
11698316 72096 None 0 strain AD169 Binding pIC50 = 4.2 4.2 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 424 7 1 3 5.6 Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm050418d
CHEMBL197694 72096 None 0 strain AD169 Binding pIC50 = 4.2 4.2 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 424 7 1 3 5.6 Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm050418d
11674616 72089 None 0 strain AD169 Binding pIC50 = 4.2 4.2 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 345 6 1 3 4.1 OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccccc2)CC1 10.1021/jm050418d
CHEMBL197675 72089 None 0 strain AD169 Binding pIC50 = 4.2 4.2 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 345 6 1 3 4.1 OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccccc2)CC1 10.1021/jm050418d
11626763 72432 None 0 strain AD169 Binding pIC50 = 4.2 4.2 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 424 8 1 3 5.3 N#CC(CCCN1CCC(O)(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL198721 72432 None 0 strain AD169 Binding pIC50 = 4.2 4.2 - 0
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 424 8 1 3 5.3 N#CC(CCCN1CCC(O)(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
10526132 72502 None 0 strain AD169 Binding pIC50 = 5.2 5.2 - 1
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 419 7 1 2 6.2 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
CHEMBL142004 72502 None 0 strain AD169 Binding pIC50 = 5.2 5.2 - 1
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 419 7 1 2 6.2 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
CHEMBL198935 72502 None 0 strain AD169 Binding pIC50 = 5.2 5.2 - 1
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 419 7 1 2 6.2 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
10670785 33128 None 0 strain AD169 Binding pIC50 = 4.1 4.1 - 1
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 440 8 1 4 5.3 COc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm050418d
CHEMBL141713 33128 None 0 strain AD169 Binding pIC50 = 4.1 4.1 - 1
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 440 8 1 4 5.3 COc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm050418d
9889700 118652 None 11 strain AD169 Binding pIC50 = 5.0 5.0 - 1
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL34166 118652 None 11 strain AD169 Binding pIC50 = 5.0 5.0 - 1
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d