G12 - GPR161 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 71.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term I 365 - G.H3 N 283 G.H3.15
Van-der-waals C-term I 365 - G.H3 N 283 G.H3.15
Hydrophobic ICL2 M 133 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 M 137 34x55 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 137 34x55 G.S3 I 221 G.S3.01
Hydrophobic ICL2 V 134 34x52 G.S3 I 221 G.S3.01
Polar C-term Q 516 - G.S6 H 348 G.S6.03
Van-der-waals C-term Q 516 - G.S6 H 348 G.S6.03
Hydrophobic C-term I 365 - G.H3 F 286 G.H3.18
Polar C-term S 371 - G.H2 R 232 G.H2.01
Hydrophobic C-term S 371 - G.H2 R 232 G.H2.01
Ionic C-term D 460 - G.s2s3 K 220 G.s2s3.02
Hydrophobic H8 N 328 8x47 G.H5 L 380 G.H5.25
Hydrophobic C-term I 518 - G.H4 V 332 G.H4.12
Van-der-waals C-term I 518 - G.H4 V 332 G.H4.12
Van-der-waals C-term Q 399 - G.s3h2 Q 231 G.s3h2.03
Polar C-term L 408 - H.HA D 110 H.HA.24
Van-der-waals C-term L 408 - H.HA D 110 H.HA.24
Hydrophobic C-term S 401 - G.hfs2 A 207 G.hfs2.04
Van-der-waals C-term S 401 - G.hfs2 A 207 G.hfs2.04
Polar TM4 N 142 4x40 G.HN R 52 G.HN.52
Hydrophobic C-term D 404 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term D 404 - G.s4h3 M 262 G.s4h3.09
Hydrophobic ICL2 M 133 34x51 G.S3 F 223 G.S3.03
Van-der-waals ICL2 M 133 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM6 K 267 6x32 G.H5 M 379 G.H5.24
Polar C-term L 368 - G.H2 R 235 G.H2.04
Hydrophobic C-term L 368 - G.H2 R 235 G.H2.04
Van-der-waals C-term L 368 - G.H2 R 235 G.H2.04
Polar C-term S 401 - G.s3h2 Q 231 G.s3h2.03
Hydrophobic C-term S 401 - G.s3h2 Q 231 G.s3h2.03
Van-der-waals C-term S 401 - G.s3h2 Q 231 G.s3h2.03
Hydrophobic C-term L 407 - H.HA D 110 H.HA.24
Van-der-waals C-term L 407 - H.HA D 110 H.HA.24
Hydrophobic ICL2 P 132 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM5 V 214 5x64 G.H5 L 371 G.H5.16
Hydrophobic C-term L 408 - H.HA A 111 H.HA.25
Hydrophobic C-term N 363 - G.H3 T 279 G.H3.11
Van-der-waals C-term N 363 - G.H3 T 279 G.H3.11
Van-der-waals C-term L 407 - H.HA K 114 H.HA.28
Hydrophobic C-term L 368 - G.H2 W 238 G.H2.07
Hydrophobic C-term I 365 - G.H2 W 238 G.H2.07
Polar TM3 A 128 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 128 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 128 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 129 3x54 G.H5 L 375 G.H5.20
Hydrophobic C-term L 407 - H.HB M 132 H.HB.10
Hydrophobic TM3 V 129 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 129 3x54 G.H5 L 371 G.H5.16
Hydrophobic C-term I 365 - G.H3 T 279 G.H3.11
Hydrophobic C-term I 518 - G.S6 F 350 G.S6.05
Hydrophobic TM5 K 218 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 K 218 5x68 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 M 133 34x51 G.S1 V 58 G.S1.02
Hydrophobic C-term G 402 - G.hfs2 A 207 G.hfs2.04
Van-der-waals C-term G 402 - G.hfs2 A 207 G.hfs2.04
Hydrophobic TM2 T 60 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 T 60 2x37 G.hns1 R 55 G.hns1.02
Hydrophobic C-term I 518 - G.H4 R 329 G.H4.09
Van-der-waals C-term I 518 - G.H4 R 329 G.H4.09
Hydrophobic TM5 K 218 5x68 G.H5 L 375 G.H5.20
Van-der-waals TM5 K 218 5x68 G.H5 L 375 G.H5.20
Hydrophobic C-term R 364 - G.H3 T 279 G.H3.11
Hydrophobic C-term M 406 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term M 406 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term L 368 - G.H3 I 276 G.H3.08
Van-der-waals C-term L 368 - G.H3 I 276 G.H3.08
Polar C-term L 408 - H.HA K 114 H.HA.28
Hydrophobic C-term L 408 - H.HA K 114 H.HA.28
Van-der-waals C-term L 408 - H.HA K 114 H.HA.28
Hydrophobic C-term I 365 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term I 365 - G.h2s4 F 242 G.h2s4.01
Polar H8 K 329 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 K 329 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 329 8x48 G.H5 Q 381 G.H5.26
Hydrophobic C-term I 361 - G.H3 K 284 G.H3.16
Van-der-waals C-term I 361 - G.H3 K 284 G.H3.16
Hydrophobic TM4 T 140 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 140 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic C-term S 517 - G.S6 H 348 G.S6.03
Van-der-waals C-term S 517 - G.S6 H 348 G.S6.03
Hydrophobic C-term I 518 - G.S6 H 348 G.S6.03
Hydrophobic ICL2 P 132 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 132 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 P 132 34x50 G.H5 L 371 G.H5.16
Polar C-term L 407 - G.s4h3 R 265 G.s4h3.12
Hydrophobic ICL2 M 137 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 M 137 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 M 133 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 133 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM6 K 267 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 267 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM7 W 327 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 W 327 7x56 G.H5 L 380 G.H5.25
Hydrophobic C-term I 518 - G.H4 Q 328 G.H4.08
Van-der-waals C-term I 518 - G.H4 Q 328 G.H4.08
Hydrophobic C-term M 406 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term M 406 - G.s4h3 M 262 G.s4h3.09
Hydrophobic TM5 A 215 5x65 G.H5 M 379 G.H5.24
Hydrophobic TM5 A 215 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 M 137 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic C-term I 518 - G.H4 Q 333 G.H4.13
Van-der-waals C-term I 518 - G.H4 Q 333 G.H4.13
Hydrophobic TM3 R 125 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 V 129 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 129 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 T 271 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 271 6x36 G.H5 L 380 G.H5.25
Hydrophobic C-term L 368 - G.H3 T 279 G.H3.11
Hydrophobic C-term L 408 - H.hdhe F 173 H.hdhe.01
Hydrophobic ICL2 M 133 34x51 G.H5 K 367 G.H5.12
Hydrophobic C-term I 361 - G.H3 N 283 G.H3.15
Ionic C-term E 520 - G.h4s6 R 342 G.h4s6.11
Polar C-term E 520 - G.h4s6 R 342 G.h4s6.11
Hydrophobic C-term E 520 - G.h4s6 R 342 G.h4s6.11
Van-der-waals C-term E 520 - G.h4s6 R 342 G.h4s6.11
Hydrophobic C-term I 365 - G.H3 I 280 G.H3.12
Van-der-waals C-term I 365 - G.H3 I 280 G.H3.12
Polar C-term E 519 - G.H4 Q 333 G.H4.13
Van-der-waals C-term E 519 - G.H4 Q 333 G.H4.13
Polar TM6 T 271 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 271 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 271 6x36 G.H5 M 379 G.H5.24
Hydrophobic C-term M 405 - H.HA V 107 H.HA.21
Van-der-waals C-term M 405 - H.HA V 107 H.HA.21
Hydrophobic C-term L 368 - G.H3 I 280 G.H3.12
Hydrophobic TM6 A 268 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 268 6x33 G.H5 M 379 G.H5.24
Van-der-waals C-term T 403 - H.HA K 103 H.HA.17
Hydrophobic ICL2 P 136 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 136 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 M 133 34x51 G.H5 V 366 G.H5.11
Van-der-waals ICL2 M 133 34x51 G.H5 V 366 G.H5.11
Ionic C-term D 400 - G.hfs2 K 209 G.hfs2.06
Polar C-term D 400 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term D 400 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term D 400 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term E 519 - G.H4 R 329 G.H4.09
Hydrophobic C-term M 405 - H.HA R 106 H.HA.20
Van-der-waals C-term M 405 - H.HA R 106 H.HA.20
Polar ICL2 P 136 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 136 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 136 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic C-term G 369 - G.H2 R 235 G.H2.04
Hydrophobic ICL2 M 137 34x55 G.S3 P 222 G.S3.02
Polar TM5 K 218 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 218 5x68 G.H5 D 368 G.H5.13
Hydrophobic C-term L 515 - G.H5 F 361 G.H5.06
Van-der-waals C-term L 515 - G.H5 F 361 G.H5.06
Hydrophobic ICL2 M 133 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 133 34x51 G.S3 I 221 G.S3.01
Hydrophobic C-term G 369 - G.H2 Q 236 G.H2.05
Hydrophobic TM3 A 128 3x53 G.H5 I 378 G.H5.23
Hydrophobic C-term G 369 - G.H2 R 232 G.H2.01
Van-der-waals C-term G 369 - G.H2 R 232 G.H2.01
Polar TM5 K 218 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 K 218 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 K 218 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM7 I 323 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 I 323 7x52 G.H5 L 380 G.H5.25
Ionic C-term D 410 - H.HA K 114 H.HA.28
Hydrophobic C-term D 410 - H.HA K 114 H.HA.28
Van-der-waals C-term D 410 - H.HA K 114 H.HA.28
Hydrophobic C-term P 372 - G.H2 R 232 G.H2.01