Gi1 - GPR52 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 79.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
01
iPTM Score: 0.3
01
PAE mean: 22.8
031


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
A02R03G.hns1F06D09C23G24F26G.H5GproteinR3x50F5x80A3x53R6x31T3x55S34x52I3x54K3x56R5x76M6x35P34x50GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.H5GPCR segments:ICL2TM3TM5TM6

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
3x503x533x543x553x5634x5034x5134x5234x565x625x655x665x695x705x725x735x765x806x276x286x306x316x336x346x35G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.21G.H5.20G.H5.19G.H5.16G.H5.13G.H5.09G.H5.06G.h2s4.05G.S3.01G.s2s3.01G.S1.02G.S1.01G.hns1.03G.hns1.02G.hns1.01G.HN.52G.HN.51Res. Pos.GPR52 (AFM_GPR52_HUMAN_GNAI1_HUMAN)- (AFM_GPR52_HUMAN_GNAI1_HUMAN)-------------------------RAITKPLSLIICHTEIRFHSDRYAMPLSLRAITKIICHTEIRFHSDRYAMNLAEVTARDCLLGEFIKDDFKG

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.