Gq - GPR52 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 N 150 34x54 G.hns1 R 37 G.hns1.02
Polar ICL3 H 247 - G.H4 K 311 G.H4.13
Ionic TM5 H 233 5x69 G.H5 D 346 G.H5.13
Polar TM5 H 233 5x69 G.H5 D 346 G.H5.13
Hydrophobic TM5 H 233 5x69 G.H5 D 346 G.H5.13
Van-der-waals TM5 H 233 5x69 G.H5 D 346 G.H5.13
Hydrophobic TM5 I 229 5x65 G.H5 L 349 G.H5.16
Ionic TM5 R 241 5x77 G.h4s6 D 321 G.h4s6.12
Polar TM5 R 241 5x77 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM5 R 241 5x77 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM5 F 244 5x80 G.H4 L 310 G.H4.12
Van-der-waals TM5 F 244 5x80 G.H4 L 310 G.H4.12
Polar ICL2 Q 151 34x55 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 Q 151 34x55 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 L 147 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 147 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM5 H 233 5x69 G.H5 L 353 G.H5.20
Van-der-waals TM5 H 233 5x69 G.H5 L 353 G.H5.20
Hydrophobic TM6 D 260 6x30 G.H5 V 359 G.H5.26
Van-der-waals TM6 D 260 6x30 G.H5 V 359 G.H5.26
Hydrophobic TM5 C 230 5x66 G.H5 V 359 G.H5.26
Hydrophobic TM3 A 142 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 142 3x53 G.H5 Y 356 G.H5.23
Ionic TM5 R 243 5x79 G.H4 E 307 G.H4.09
Polar TM5 R 243 5x79 G.H4 E 307 G.H4.09
Hydrophobic TM5 R 243 5x79 G.H4 E 307 G.H4.09
Van-der-waals TM5 R 243 5x79 G.H4 E 307 G.H4.09
Hydrophobic TM6 Y 263 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 Y 263 6x33 G.H5 V 359 G.H5.26
Polar TM2 T 76 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 T 76 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 76 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 146 34x50 G.H5 K 345 G.H5.12
Van-der-waals TM6 P 259 6x29 G.H5 V 359 G.H5.26
Polar TM6 A 264 6x34 G.H5 N 357 G.H5.24
Hydrophobic TM3 I 143 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 143 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 P 146 34x50 G.H5 L 349 G.H5.16
Hydrophobic TM2 Y 74 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 Y 74 2x37 G.H5 E 355 G.H5.22
Polar TM5 H 233 5x69 G.H5 Q 350 G.H5.17
Hydrophobic TM5 H 233 5x69 G.H5 Q 350 G.H5.17
Van-der-waals TM5 H 233 5x69 G.H5 Q 350 G.H5.17
Polar TM7 S 320 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM3 I 143 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 143 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM5 C 230 5x66 G.H5 L 353 G.H5.20
Hydrophobic TM3 R 139 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM5 H 233 5x69 G.H5 L 349 G.H5.16
Van-der-waals TM5 H 233 5x69 G.H5 L 349 G.H5.16
Hydrophobic TM6 L 267 6x37 G.H5 Y 356 G.H5.23
Van-der-waals TM6 L 267 6x37 G.H5 Y 356 G.H5.23
Hydrophobic H8 N 321 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM6 Y 263 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 Y 263 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM5 I 226 5x62 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 147 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 147 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM5 I 237 5x73 G.H5 Q 350 G.H5.17
Van-der-waals TM5 I 237 5x73 G.H5 Q 350 G.H5.17
Hydrophobic TM6 L 267 6x37 G.H5 N 357 G.H5.24
Ionic TM5 R 240 5x76 G.H5 D 346 G.H5.13
Polar TM5 R 240 5x76 G.H5 D 346 G.H5.13
Van-der-waals TM5 R 240 5x76 G.H5 D 346 G.H5.13
Van-der-waals TM6 D 260 6x30 G.H5 L 358 G.H5.25
Hydrophobic TM6 Y 263 6x33 G.H5 N 357 G.H5.24
Van-der-waals TM6 Y 263 6x33 G.H5 N 357 G.H5.24
Polar TM3 A 142 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM6 L 267 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 267 6x37 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 147 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 L 147 34x51 G.S1 L 40 G.S1.02
Hydrophobic ICL2 P 146 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 146 34x50 G.H5 I 348 G.H5.15
Polar TM3 D 138 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 138 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM5 F 244 5x80 G.H4 V 314 G.H4.16
Hydrophobic TM5 I 237 5x73 G.h4s6 I 323 G.h4s6.20
Polar ICL2 Y 149 34x53 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 Y 149 34x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 147 34x51 G.H5 V 344 G.H5.11
Polar TM5 R 240 5x76 G.S6 Y 325 G.S6.02
Hydrophobic TM5 R 240 5x76 G.S6 Y 325 G.S6.02
Van-der-waals TM5 R 240 5x76 G.S6 Y 325 G.S6.02
Hydrophobic TM3 I 143 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 Q 151 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 Q 151 34x55 G.hns1 R 38 G.hns1.03
Polar TM6 A 264 6x34 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 264 6x34 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 264 6x34 G.H5 L 358 G.H5.25
Polar TM5 R 241 5x77 G.h4s6 S 320 G.h4s6.11
Van-der-waals TM5 R 241 5x77 G.h4s6 S 320 G.h4s6.11
Hydrophobic ICL2 L 147 34x51 G.H5 K 345 G.H5.12
Polar TM2 T 75 2x38 G.H5 Y 356 G.H5.23
Hydrophobic TM4 P 155 4x39 G.hns1 R 37 G.hns1.02