Gi3 - GPR61 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 74.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 18.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 148 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 M 148 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM4 G 157 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 G 157 4x40 G.HN R 24 G.HN.48
Polar TM5 Q 241 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 241 5x71 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 241 5x71 G.H5 D 341 G.H5.13
Polar TM4 T 155 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 T 155 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 T 155 4x38 G.HN E 28 G.HN.52
Polar C-term G 416 - G.S2 E 186 G.S2.03
Hydrophobic C-term G 416 - G.S2 E 186 G.S2.03
Van-der-waals C-term G 416 - G.S2 E 186 G.S2.03
Hydrophobic C-term F 384 - G.H3 K 248 G.H3.07
Ionic C-term K 404 - G.s4h3 E 238 G.s4h3.12
Polar C-term K 404 - G.s4h3 E 238 G.s4h3.12
Van-der-waals C-term K 404 - G.s4h3 E 238 G.s4h3.12
Polar C-term I 418 - G.S2 I 184 G.S2.01
Hydrophobic C-term I 418 - G.S2 I 184 G.S2.01
Van-der-waals C-term I 418 - G.S2 I 184 G.S2.01
Hydrophobic C-term F 381 - G.H3 I 253 G.H3.12
Van-der-waals C-term F 381 - G.H3 I 253 G.H3.12
Polar TM4 L 156 4x39 G.HN R 24 G.HN.48
Hydrophobic TM4 L 156 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 L 156 4x39 G.HN R 24 G.HN.48
Hydrophobic TM5 L 245 5x75 G.H5 A 338 G.H5.10
Van-der-waals TM5 L 245 5x75 G.H5 A 338 G.H5.10
Hydrophobic TM5 M 231 5x61 G.H5 C 351 G.H5.23
Hydrophobic TM5 A 239 5x69 G.H5 Y 354 G.H5.26
Polar C-term Q 417 - G.hfs2 T 182 G.hfs2.06
Van-der-waals C-term Q 417 - G.hfs2 T 182 G.hfs2.06
Hydrophobic C-term I 414 - G.hfs2 T 181 G.hfs2.05
Polar TM5 H 242 5x72 G.H5 K 345 G.H5.17
Hydrophobic TM5 H 242 5x72 G.H5 K 345 G.H5.17
Van-der-waals TM5 H 242 5x72 G.H5 K 345 G.H5.17
Hydrophobic TM3 V 144 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL2 M 148 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 M 148 34x51 G.S1 V 34 G.S1.02
Hydrophobic C-term F 384 - G.H3 S 252 G.H3.11
Van-der-waals C-term F 384 - G.H3 S 252 G.H3.11
Polar TM3 Y 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 Y 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 Y 143 3x53 G.H5 N 347 G.H5.19
Polar H8 Q 347 8x49 G.H5 E 350 G.H5.22
Hydrophobic H8 Q 347 8x49 G.H5 E 350 G.H5.22
Van-der-waals H8 Q 347 8x49 G.H5 E 350 G.H5.22
Hydrophobic C-term F 381 - G.H3 N 256 G.H3.15
Van-der-waals C-term F 381 - G.H3 N 256 G.H3.15
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Ionic ICL2 R 149 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 149 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 149 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 149 34x52 G.s2s3 D 193 G.s2s3.02
Polar TM6 K 284 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 284 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 284 6x32 G.H5 Y 354 G.H5.26
Van-der-waals H8 N 345 8x47 G.H5 E 350 G.H5.22
Polar TM5 H 242 5x72 G.H5 Y 354 G.H5.26
Hydrophobic TM6 V 288 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 288 6x36 G.H5 L 353 G.H5.25
Polar ICL2 V 152 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 V 152 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 V 152 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic C-term F 381 - G.h2s4 F 215 G.h2s4.01
Van-der-waals C-term F 381 - G.h2s4 F 215 G.h2s4.01
Hydrophobic C-term I 414 - G.hfs2 V 179 G.hfs2.03
Hydrophobic C-term P 407 - H.HA Q 79 H.HA.17
Van-der-waals C-term P 407 - H.HA Q 79 H.HA.17
Hydrophobic C-term L 426 - G.H2 H 213 G.H2.09
Van-der-waals C-term L 426 - G.H2 H 213 G.H2.09
Hydrophobic C-term L 385 - G.H2 W 211 G.H2.07
Van-der-waals C-term L 385 - G.H2 W 211 G.H2.07
Aromatic C-term F 412 - H.HA Y 69 H.HA.07
Hydrophobic C-term F 412 - H.HA Y 69 H.HA.07
Van-der-waals C-term F 412 - H.HA Y 69 H.HA.07
Hydrophobic ICL3 M 249 - G.H4 A 301 G.H4.08
Hydrophobic ICL2 E 151 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 E 151 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals C-term L 385 - G.H2 R 205 G.H2.01
Hydrophobic TM5 M 231 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 231 5x61 G.H5 L 353 G.H5.25
Hydrophobic C-term G 416 - G.S2 V 185 G.S2.02
Van-der-waals C-term G 416 - G.S2 V 185 G.S2.02
Hydrophobic ICL3 M 249 - G.H4 Y 296 G.H4.03
Hydrophobic TM5 P 246 5x76 G.H5 F 334 G.H5.06
Van-der-waals TM5 P 246 5x76 G.H5 F 334 G.H5.06
Polar ICL2 V 152 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 V 152 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 V 152 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 153 34x56 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 R 153 34x56 G.hns1 K 32 G.hns1.03
Hydrophobic C-term F 384 - G.H3 L 249 G.H3.08
Van-der-waals C-term F 384 - G.H3 L 249 G.H3.08
Polar TM4 L 156 4x39 G.HN E 28 G.HN.52
Aromatic ICL3 W 248 - G.HG K 271 G.HG.01
Hydrophobic ICL2 V 152 34x55 G.HN K 29 G.HN.53
Van-der-waals ICL2 V 152 34x55 G.HN K 29 G.HN.53
Hydrophobic ICL2 M 148 34x51 G.S3 F 196 G.S3.03
Van-der-waals ICL2 M 148 34x51 G.S3 F 196 G.S3.03
Polar ICL2 M 148 34x51 G.S3 Y 195 G.S3.02
Hydrophobic ICL2 M 148 34x51 G.S3 Y 195 G.S3.02
Van-der-waals ICL2 M 148 34x51 G.S3 Y 195 G.S3.02
Ionic ICL3 R 253 - G.H4 E 298 G.H4.05
Polar ICL3 R 253 - G.H4 E 298 G.H4.05
Ionic TM2 K 75 2x39 G.H5 E 350 G.H5.22
Polar TM2 K 75 2x39 G.H5 E 350 G.H5.22
Van-der-waals TM2 K 75 2x39 G.H5 E 350 G.H5.22
Polar H8 R 346 8x48 G.H5 E 350 G.H5.22
Van-der-waals H8 R 346 8x48 G.H5 E 350 G.H5.22
Van-der-waals ICL2 P 147 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM3 H 146 3x56 G.S3 L 194 G.S3.01
Van-der-waals TM3 H 146 3x56 G.S3 L 194 G.S3.01
Hydrophobic ICL3 M 249 - G.H4 A 300 G.H4.07
Van-der-waals ICL3 M 249 - G.H4 A 300 G.H4.07
Hydrophobic TM3 V 144 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 144 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 284 6x32 G.H5 L 353 G.H5.25
Hydrophobic C-term F 381 - G.H3 S 252 G.H3.11
Van-der-waals C-term F 381 - G.H3 S 252 G.H3.11
Hydrophobic TM5 A 235 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 A 235 5x65 G.H5 L 348 G.H5.20
Polar C-term E 420 - G.hfs2 G 183 G.hfs2.07
Hydrophobic C-term E 420 - G.hfs2 G 183 G.hfs2.07
Van-der-waals C-term E 420 - G.hfs2 G 183 G.hfs2.07
Hydrophobic ICL2 Y 150 34x53 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 Y 150 34x53 G.hns1 K 32 G.hns1.03
Hydrophobic TM5 Y 228 5x58 G.H5 L 353 G.H5.25
Hydrophobic C-term L 382 - G.H2 I 212 G.H2.08
Hydrophobic TM3 Y 143 3x53 G.H5 C 351 G.H5.23
Polar ICL2 R 149 34x52 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 R 149 34x52 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 R 149 34x52 G.hns1 K 32 G.hns1.03
Hydrophobic TM5 L 245 5x75 G.S6 H 322 G.S6.04
Van-der-waals TM5 L 245 5x75 G.S6 H 322 G.S6.04
Ionic C-term E 406 - G.hfs2 K 180 G.hfs2.04
Polar C-term E 406 - G.hfs2 K 180 G.hfs2.04
Van-der-waals C-term E 406 - G.hfs2 K 180 G.hfs2.04
Hydrophobic ICL2 M 148 34x51 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 M 148 34x51 G.hns1 K 32 G.hns1.03
Hydrophobic C-term Q 417 - G.S2 V 185 G.S2.02
Ionic TM3 H 146 3x56 G.s2s3 D 193 G.s2s3.02
Polar TM3 H 146 3x56 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 H 146 3x56 G.s2s3 D 193 G.s2s3.02
Van-der-waals TM3 H 146 3x56 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 E 151 34x54 G.HN E 28 G.HN.52
Van-der-waals ICL2 E 151 34x54 G.HN E 28 G.HN.52
Polar TM4 G 157 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 G 157 4x40 G.HN E 28 G.HN.52
Ionic C-term E 420 - G.H2 K 210 G.H2.06
Polar C-term E 420 - G.H2 K 210 G.H2.06
Hydrophobic C-term E 420 - G.H2 K 210 G.H2.06
Van-der-waals C-term E 420 - G.H2 K 210 G.H2.06
Hydrophobic TM6 V 288 6x36 G.H5 G 352 G.H5.24
Polar C-term E 378 - G.H3 W 258 G.H3.17
Hydrophobic C-term E 378 - G.H3 W 258 G.H3.17
Van-der-waals C-term E 378 - G.H3 W 258 G.H3.17
Hydrophobic C-term I 377 - G.H3 K 257 G.H3.16
Hydrophobic ICL3 M 249 - G.H4 E 297 G.H4.04
Van-der-waals ICL3 M 249 - G.H4 E 297 G.H4.04
Hydrophobic TM3 V 144 3x54 G.H5 N 347 G.H5.19
Polar C-term L 385 - G.H2 K 209 G.H2.05
Hydrophobic C-term L 385 - G.H2 K 209 G.H2.05
Hydrophobic C-term F 412 - H.HA Q 68 H.HA.06
Polar TM3 Y 143 3x53 G.H5 E 350 G.H5.22
Hydrophobic TM3 Y 143 3x53 G.H5 E 350 G.H5.22
Van-der-waals TM3 Y 143 3x53 G.H5 E 350 G.H5.22
Hydrophobic ICL2 P 147 34x50 G.S3 L 194 G.S3.01
Van-der-waals ICL2 P 147 34x50 G.S3 L 194 G.S3.01
Polar TM6 K 284 6x32 G.H5 G 352 G.H5.24
Hydrophobic TM6 K 284 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 284 6x32 G.H5 G 352 G.H5.24
Hydrophobic ICL2 E 151 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 E 151 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic C-term F 412 - H.HA V 72 H.HA.10
Van-der-waals C-term F 412 - H.HA V 72 H.HA.10
Hydrophobic C-term L 385 - G.H2 R 208 G.H2.04
Van-der-waals C-term L 385 - G.H2 R 208 G.H2.04
Hydrophobic TM6 G 281 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 G 281 6x29 G.H5 Y 354 G.H5.26
Van-der-waals C-term P 415 - G.S2 V 185 G.S2.02
Hydrophobic C-term V 410 - H.HA V 71 H.HA.09
Hydrophobic ICL3 M 249 - G.S6 F 323 G.S6.05
Hydrophobic C-term V 410 - H.HA S 75 H.HA.13
Van-der-waals C-term V 410 - H.HA S 75 H.HA.13
Hydrophobic ICL3 T 251 - G.H4 E 297 G.H4.04
Hydrophobic TM5 L 245 5x75 G.H5 F 334 G.H5.06
Hydrophobic C-term I 418 - G.S2 E 186 G.S2.03
Hydrophobic C-term F 412 - G.hfs2 V 179 G.hfs2.03
Hydrophobic ICL2 P 147 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 234 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 234 5x64 G.H5 I 344 G.H5.16
Hydrophobic C-term Q 386 - G.H2 K 209 G.H2.05
Van-der-waals C-term Q 386 - G.H2 K 209 G.H2.05
Polar TM6 A 285 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 285 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 285 6x33 G.H5 L 353 G.H5.25
Hydrophobic C-term I 414 - G.S2 V 185 G.S2.02