G12 - MT2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 142 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 142 3x54 G.H5 I 378 G.H5.23
Polar ICL2 M 146 34x51 G.HN R 52 G.HN.52
Hydrophobic ICL2 M 146 34x51 G.HN R 52 G.HN.52
Van-der-waals ICL2 M 146 34x51 G.HN R 52 G.HN.52
Polar ICL2 R 150 34x55 G.HN R 52 G.HN.52
Hydrophobic ICL2 R 150 34x55 G.HN R 52 G.HN.52
Van-der-waals ICL2 R 150 34x55 G.HN R 52 G.HN.52
Polar ICL2 R 150 34x55 G.HN A 48 G.HN.48
Hydrophobic ICL2 R 150 34x55 G.HN A 48 G.HN.48
Van-der-waals ICL2 R 150 34x55 G.HN A 48 G.HN.48
Polar TM3 C 143 3x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 C 143 3x55 G.hns1 R 56 G.hns1.03
Van-der-waals TM3 C 143 3x55 G.hns1 R 56 G.hns1.03
Polar TM6 K 243 6x27 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 L 242 6x26 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 242 6x26 G.H5 M 379 G.H5.24
Hydrophobic TM6 L 247 6x31 G.H5 M 379 G.H5.24
Polar ICL2 M 146 34x51 G.HN A 53 G.HN.53
Hydrophobic ICL2 M 146 34x51 G.HN A 53 G.HN.53
Van-der-waals ICL2 M 146 34x51 G.HN A 53 G.HN.53
Polar ICL2 R 150 34x55 G.HN R 51 G.HN.51
Hydrophobic ICL2 R 150 34x55 G.HN R 51 G.HN.51
Van-der-waals ICL2 R 150 34x55 G.HN R 51 G.HN.51
Hydrophobic TM6 L 242 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM2 N 76 2x40 G.H5 Q 381 G.H5.26
Van-der-waals TM2 N 76 2x40 G.H5 Q 381 G.H5.26
Hydrophobic ICL1 K 70 12x49 G.h3s5 F 287 G.h3s5.01
Van-der-waals ICL1 K 70 12x49 G.h3s5 F 287 G.h3s5.01
Hydrophobic TM3 I 142 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 375 G.H5.20
Polar ICL2 A 147 34x52 G.HN R 52 G.HN.52
Hydrophobic ICL2 A 147 34x52 G.HN R 52 G.HN.52
Van-der-waals ICL2 A 147 34x52 G.HN R 52 G.HN.52
Hydrophobic TM6 L 242 6x26 G.H5 K 376 G.H5.21
Van-der-waals TM6 L 242 6x26 G.H5 K 376 G.H5.21
Polar ICL2 M 146 34x51 G.hns1 V 54 G.hns1.01
Van-der-waals ICL2 M 146 34x51 G.hns1 V 54 G.hns1.01
Ionic TM6 D 246 6x30 G.H5 K 376 G.H5.21
Polar TM6 D 246 6x30 G.H5 K 376 G.H5.21
Hydrophobic TM6 D 246 6x30 G.H5 K 376 G.H5.21
Van-der-waals TM6 D 246 6x30 G.H5 K 376 G.H5.21
Polar H8 N 312 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 312 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 S 249 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 249 6x33 G.H5 M 379 G.H5.24
Van-der-waals ICL2 R 150 34x55 G.HN A 53 G.HN.53
Polar TM3 Y 141 3x53 G.H5 Q 381 G.H5.26
Hydrophobic TM3 Y 141 3x53 G.H5 Q 381 G.H5.26
Van-der-waals TM3 Y 141 3x53 G.H5 Q 381 G.H5.26
Hydrophobic TM3 Y 141 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 Y 141 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 H 149 34x54 G.hns1 V 54 G.hns1.01
Van-der-waals ICL2 H 149 34x54 G.hns1 V 54 G.hns1.01
Polar TM6 F 250 6x34 G.H5 M 379 G.H5.24
Hydrophobic TM6 F 250 6x34 G.H5 M 379 G.H5.24
Van-der-waals TM6 F 250 6x34 G.H5 M 379 G.H5.24
Polar ICL2 S 145 34x50 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 S 145 34x50 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 S 145 34x50 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 M 146 34x51 G.S3 P 222 G.S3.02
Van-der-waals ICL2 M 146 34x51 G.S3 P 222 G.S3.02
Polar ICL2 R 150 34x55 G.HN L 47 G.HN.47
Hydrophobic ICL2 R 150 34x55 G.HN L 47 G.HN.47
Van-der-waals ICL2 R 150 34x55 G.HN L 47 G.HN.47
Polar TM3 R 138 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 M 146 34x51 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 M 146 34x51 G.hns1 R 56 G.hns1.03
Polar TM5 A 234 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 A 234 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 A 234 5x72 G.H5 D 368 G.H5.13
Polar ICL2 H 149 34x54 G.HN R 51 G.HN.51
Hydrophobic ICL2 H 149 34x54 G.HN R 51 G.HN.51
Van-der-waals ICL2 H 149 34x54 G.HN R 51 G.HN.51
Polar ICL2 H 149 34x54 G.hns1 R 55 G.hns1.02
Aromatic ICL2 H 149 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 H 149 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 H 149 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 M 146 34x51 G.S1 L 57 G.S1.01
Polar TM6 C 241 6x25 G.H5 K 376 G.H5.21
Aromatic TM3 Y 141 3x53 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 Y 141 3x53 G.hns1 R 55 G.hns1.02
Van-der-waals TM3 Y 141 3x53 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 L 240 6x24 G.S6 F 347 G.S6.02
Hydrophobic TM6 D 246 6x30 G.H5 M 379 G.H5.24
Van-der-waals TM6 D 246 6x30 G.H5 M 379 G.H5.24
Polar ICL2 R 150 34x55 G.HN R 49 G.HN.49
Hydrophobic ICL2 R 150 34x55 G.HN R 49 G.HN.49
Van-der-waals ICL2 R 150 34x55 G.HN R 49 G.HN.49
Van-der-waals ICL2 M 146 34x51 G.HN R 51 G.HN.51
Hydrophobic TM4 R 153 4x38 G.HN R 51 G.HN.51
Van-der-waals TM4 R 153 4x38 G.HN R 51 G.HN.51
Polar ICL2 Y 148 34x53 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 Y 148 34x53 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Y 148 34x53 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 V 227 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM5 K 233 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 233 5x71 G.H5 D 368 G.H5.13
Polar ICL2 R 150 34x55 G.HN E 50 G.HN.50
Hydrophobic ICL2 R 150 34x55 G.HN E 50 G.HN.50
Van-der-waals ICL2 R 150 34x55 G.HN E 50 G.HN.50
Polar TM5 K 233 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM5 K 233 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 K 233 5x71 G.H5 H 364 G.H5.09
Hydrophobic ICL3 K 235 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 K 235 - G.H5 F 361 G.H5.06
Hydrophobic TM6 L 240 6x24 G.H5 Q 372 G.H5.17
Van-der-waals TM6 L 240 6x24 G.H5 Q 372 G.H5.17
Polar TM3 H 144 3x56 G.hns1 R 56 G.hns1.03
Aromatic TM3 H 144 3x56 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 H 144 3x56 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 S 249 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 S 249 6x33 G.H5 L 380 G.H5.25
Polar H8 N 314 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 N 314 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 I 151 34x56 G.HN R 52 G.HN.52
Van-der-waals ICL2 I 151 34x56 G.HN R 52 G.HN.52
Polar TM3 R 138 3x50 G.H5 Q 381 G.H5.26
Hydrophobic TM3 R 138 3x50 G.H5 Q 381 G.H5.26
Van-der-waals TM3 R 138 3x50 G.H5 Q 381 G.H5.26
Polar ICL2 Y 152 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Y 152 34x57 G.hns1 R 55 G.hns1.02
Polar ICL2 S 145 34x50 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 145 34x50 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 145 34x50 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 I 142 3x54 G.H5 M 379 G.H5.24
Hydrophobic TM6 L 240 6x24 G.H5 T 369 G.H5.14
Van-der-waals TM6 L 240 6x24 G.H5 T 369 G.H5.14
Polar TM4 H 156 4x41 G.HN R 51 G.HN.51
Hydrophobic TM4 H 156 4x41 G.HN R 51 G.HN.51
Van-der-waals TM4 H 156 4x41 G.HN R 51 G.HN.51
Polar TM2 N 73 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM2 N 73 2x37 G.H5 Q 381 G.H5.26
Van-der-waals TM2 N 73 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM6 L 240 6x24 G.H5 D 368 G.H5.13
Polar ICL2 M 146 34x51 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 M 146 34x51 G.hns1 R 55 G.hns1.02