G15 - PrRP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term H 360 - G.HN M 1 G.HN.01
Hydrophobic TM6 T 276 6x33 G.H5 L 368 G.H5.20
Hydrophobic TM3 V 162 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 V 162 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM6 R 272 6x29 G.H5 N 372 G.H5.24
Hydrophobic TM5 R 255 5x68 G.H5 L 364 G.H5.16
Van-der-waals TM5 R 255 5x68 G.H5 L 364 G.H5.16
Hydrophobic ICL2 P 166 34x50 G.H5 L 364 G.H5.16
Hydrophobic ICL2 P 166 34x50 G.H5 R 360 G.H5.12
Van-der-waals ICL2 P 166 34x50 G.H5 R 360 G.H5.12
Hydrophobic ICL2 L 167 34x51 G.H5 R 360 G.H5.12
Van-der-waals ICL2 L 167 34x51 G.H5 R 360 G.H5.12
Polar TM5 C 260 5x73 G.S6 S 341 G.S6.03
Van-der-waals TM5 C 260 5x73 G.S6 S 341 G.S6.03
Polar ICL3 Q 265 - G.S6 L 339 G.S6.01
Hydrophobic ICL3 Q 265 - G.S6 L 339 G.S6.01
Van-der-waals ICL3 Q 265 - G.S6 L 339 G.S6.01
Hydrophobic C-term I 370 - G.h2s4 F 223 G.h2s4.01
Ionic H8 D 340 8x48 G.h4s6 R 335 G.h4s6.17
Polar ICL2 R 169 34x53 G.HN K 37 G.HN.52
Van-der-waals ICL2 R 169 34x53 G.HN K 37 G.HN.52
Polar ICL2 R 170 - G.H5 Y 367 G.H5.19
Aromatic ICL2 R 170 - G.H5 Y 367 G.H5.19
Hydrophobic ICL2 R 170 - G.H5 Y 367 G.H5.19
Van-der-waals ICL2 R 170 - G.H5 Y 367 G.H5.19
Polar H8 H 339 8x47 G.H5 I 371 G.H5.23
Hydrophobic H8 H 339 8x47 G.H5 I 371 G.H5.23
Van-der-waals H8 H 339 8x47 G.H5 I 371 G.H5.23
Hydrophobic TM6 W 268 6x25 G.H5 D 369 G.H5.21
Hydrophobic ICL2 L 167 34x51 G.S1 L 43 G.S1.02
Van-der-waals ICL2 L 167 34x51 G.S1 L 43 G.S1.02
Hydrophobic TM5 G 259 5x72 G.S6 S 341 G.S6.03
Van-der-waals TM5 G 259 5x72 G.S6 S 341 G.S6.03
Hydrophobic TM2 N 96 2x40 G.H5 L 374 G.H5.26
Van-der-waals TM2 N 96 2x40 G.H5 L 374 G.H5.26
Hydrophobic C-term A 358 - G.HN M 1 G.HN.01
Van-der-waals C-term A 358 - G.HN M 1 G.HN.01
Hydrophobic TM5 C 260 5x73 G.H4 L 313 G.H4.12
Hydrophobic TM5 G 259 5x72 G.S6 H 342 G.S6.04
Van-der-waals TM5 G 259 5x72 G.S6 H 342 G.S6.04
Hydrophobic TM2 T 95 2x39 G.H5 L 374 G.H5.26
Van-der-waals TM2 T 95 2x39 G.H5 L 374 G.H5.26
Polar H8 H 339 8x47 G.H5 L 374 G.H5.26
Hydrophobic H8 H 339 8x47 G.H5 L 374 G.H5.26
Van-der-waals H8 H 339 8x47 G.H5 L 374 G.H5.26
Polar H8 H 339 8x47 G.H5 L 373 G.H5.25
Hydrophobic H8 H 339 8x47 G.H5 L 373 G.H5.25
Van-der-waals H8 H 339 8x47 G.H5 L 373 G.H5.25
Hydrophobic C-term V 368 - G.H3 L 264 G.H3.15
Van-der-waals C-term V 368 - G.H3 L 264 G.H3.15
Hydrophobic TM5 P 258 5x71 G.S6 F 340 G.S6.02
Van-der-waals TM5 P 258 5x71 G.S6 F 340 G.S6.02
Hydrophobic TM5 P 258 5x71 G.H5 D 358 G.H5.10
Van-der-waals TM5 P 258 5x71 G.H5 D 358 G.H5.10
Hydrophobic C-term I 370 - G.H2 I 220 G.H2.08
Ionic H8 E 344 8x52 G.h4s6 K 332 G.h4s6.14
Polar H8 E 344 8x52 G.h4s6 K 332 G.h4s6.14
Hydrophobic H8 E 344 8x52 G.h4s6 K 332 G.h4s6.14
Van-der-waals H8 E 344 8x52 G.h4s6 K 332 G.h4s6.14
Hydrophobic TM3 L 163 3x54 G.H5 Y 367 G.H5.19
Hydrophobic TM5 V 257 5x70 G.S6 F 340 G.S6.02
Hydrophobic TM2 I 99 2x43 G.H5 L 374 G.H5.26
Van-der-waals TM2 I 99 2x43 G.H5 L 374 G.H5.26
Van-der-waals TM5 R 255 5x68 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM3 R 159 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM3 L 163 3x54 G.H5 L 368 G.H5.20
Van-der-waals TM3 L 163 3x54 G.H5 L 368 G.H5.20
Polar C-term P 359 - G.HN M 1 G.HN.01
Hydrophobic C-term P 359 - G.HN M 1 G.HN.01
Van-der-waals C-term P 359 - G.HN M 1 G.HN.01
Ionic ICL2 R 170 - G.H5 E 370 G.H5.22
Polar ICL2 R 170 - G.H5 E 370 G.H5.22
Hydrophobic ICL2 R 170 - G.H5 E 370 G.H5.22
Van-der-waals ICL2 R 170 - G.H5 E 370 G.H5.22
Hydrophobic TM3 L 163 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 L 163 3x54 G.H5 L 364 G.H5.16
Hydrophobic ICL3 Q 265 - G.h4s6 R 338 G.h4s6.20
Hydrophobic TM5 P 258 5x71 G.S6 H 342 G.S6.04
Polar TM6 T 276 6x33 G.H5 N 372 G.H5.24
Hydrophobic TM6 T 276 6x33 G.H5 N 372 G.H5.24
Van-der-waals TM6 T 276 6x33 G.H5 N 372 G.H5.24
Hydrophobic TM5 L 252 5x65 G.H5 L 368 G.H5.20
Hydrophobic ICL2 L 167 34x51 G.H5 V 363 G.H5.15
Hydrophobic ICL2 P 166 34x50 G.H5 V 363 G.H5.15
Van-der-waals ICL2 P 166 34x50 G.H5 V 363 G.H5.15
Polar ICL3 Q 265 - G.h4s6 Y 320 G.h4s6.02
Hydrophobic C-term V 368 - G.H2 I 220 G.H2.08
Hydrophobic TM5 P 258 5x71 G.H5 D 361 G.H5.13
Van-der-waals TM5 P 258 5x71 G.H5 D 361 G.H5.13
Polar H8 D 340 8x48 G.h4s6 K 332 G.h4s6.14
Hydrophobic H8 D 340 8x48 G.h4s6 K 332 G.h4s6.14
Hydrophobic TM5 V 257 5x70 G.H5 D 361 G.H5.13
Hydrophobic TM5 L 252 5x65 G.H5 L 364 G.H5.16
Hydrophobic TM6 W 268 6x25 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM6 W 268 6x25 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM7 Y 335 7x53 G.H5 L 374 G.H5.26
Van-der-waals TM7 Y 335 7x53 G.H5 L 374 G.H5.26
Hydrophobic C-term I 370 - G.H2 R 216 G.H2.04
Ionic TM5 R 255 5x68 G.H5 D 361 G.H5.13
Polar TM5 R 255 5x68 G.H5 D 361 G.H5.13
Hydrophobic TM5 R 255 5x68 G.H5 D 361 G.H5.13
Van-der-waals TM5 R 255 5x68 G.H5 D 361 G.H5.13
Ionic TM6 R 272 6x29 G.H5 D 369 G.H5.21
Polar TM6 R 272 6x29 G.H5 D 369 G.H5.21
Hydrophobic TM6 R 272 6x29 G.H5 D 369 G.H5.21
Van-der-waals TM6 R 272 6x29 G.H5 D 369 G.H5.21
Hydrophobic TM6 W 268 6x25 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 W 268 6x25 G.h4s6 R 338 G.h4s6.20
Polar TM7 A 336 7x54 G.H5 L 374 G.H5.26
Hydrophobic TM7 A 336 7x54 G.H5 L 374 G.H5.26
Van-der-waals TM7 A 336 7x54 G.H5 L 374 G.H5.26
Polar TM5 V 256 5x69 G.H5 K 357 G.H5.09
Van-der-waals TM5 V 256 5x69 G.H5 K 357 G.H5.09
Hydrophobic ICL2 L 167 34x51 G.H5 V 359 G.H5.11
Polar H8 H 339 8x47 G.H5 N 372 G.H5.24
Hydrophobic H8 H 339 8x47 G.H5 N 372 G.H5.24
Van-der-waals H8 H 339 8x47 G.H5 N 372 G.H5.24
Ionic TM6 D 269 6x26 G.h4s6 R 338 G.h4s6.20
Polar TM6 D 269 6x26 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM6 D 269 6x26 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 D 269 6x26 G.h4s6 R 338 G.h4s6.20
Polar ICL2 L 167 34x51 G.S3 T 202 G.S3.01
Hydrophobic ICL2 L 167 34x51 G.S3 T 202 G.S3.01
Van-der-waals ICL2 L 167 34x51 G.S3 T 202 G.S3.01
Hydrophobic ICL3 T 262 - G.H4 T 317 G.H4.16
Van-der-waals ICL3 T 262 - G.H4 T 317 G.H4.16
Polar ICL2 P 166 34x50 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 P 166 34x50 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 P 166 34x50 G.H5 Y 367 G.H5.19
Hydrophobic TM5 P 258 5x71 G.H5 K 357 G.H5.09
Polar TM6 R 272 6x29 G.H5 A 365 G.H5.17
Hydrophobic TM6 R 272 6x29 G.H5 A 365 G.H5.17
Van-der-waals TM6 R 272 6x29 G.H5 A 365 G.H5.17
Hydrophobic TM6 W 268 6x25 G.h4s6 S 336 G.h4s6.18
Polar H8 S 341 8x49 G.H5 L 373 G.H5.25
Hydrophobic H8 S 341 8x49 G.H5 L 373 G.H5.25
Van-der-waals H8 S 341 8x49 G.H5 L 373 G.H5.25
Hydrophobic C-term V 368 - G.H3 W 266 G.H3.17
Van-der-waals C-term V 368 - G.H3 W 266 G.H3.17
Hydrophobic ICL2 L 167 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 L 167 34x51 G.H5 F 356 G.H5.08
Hydrophobic TM3 L 163 3x54 G.H5 I 371 G.H5.23
Van-der-waals TM3 L 163 3x54 G.H5 I 371 G.H5.23
Polar TM6 R 272 6x29 G.H5 L 368 G.H5.20
Hydrophobic TM6 R 272 6x29 G.H5 L 368 G.H5.20
Van-der-waals TM6 R 272 6x29 G.H5 L 368 G.H5.20