ADGRE4P (agre4_mouse)
FAMILY
Class B2 (Adhesion) Adhesion receptors ADGRE ADGRE4P
GENE
Adgre4 (Emr4)
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Adhesion G protein-coupled receptor E4, EGF-like module receptor 4, EGF-like module-containing mucin-like hormone receptor-like 4, F4/80-like-receptor, Seven-span membrane protein FIRE
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
L
|
M
|
G
|
A
|
T
|
R
|
D
|
M
|
G
|
10 |
S
|
R
|
C
|
L
|
L
|
H
|
A
|
S
|
V
|
P
|
20 |
G
|
M
|
L
|
L
|
I
|
W
|
S
|
I
|
L
|
Q
|
30 |
M
|
M
|
N
|
I
|
S
|
A
|
S
|
C
|
P
|
Q
|
40 |
C
|
N
|
E
|
N
|
A
|
S
|
C
|
F
|
N
|
S
|
50 |
T
|
H
|
C
|
V
|
C
|
K
|
E
|
G
|
F
|
W
|
60 |
T
|
G
|
S
|
E
|
N
|
R
|
R
|
I
|
I
|
E
|
70 |
P
|
H
|
E
|
K
|
C
|
Q
|
D
|
I
|
N
|
E
|
80 |
C
|
L
|
L
|
K
|
E
|
L
|
V
|
C
|
K
|
D
|
90 |
V
|
S
|
Y
|
C
|
R
|
N
|
K
|
I
|
G
|
T
|
100 |
Y
|
I
|
C
|
S
|
C
|
V
|
V
|
K
|
Y
|
P
|
110 |
L
|
F
|
N
|
W
|
V
|
A
|
G
|
I
|
I
|
N
|
120 |
I
|
D
|
H
|
P
|
D
|
C
|
Y
|
V
|
N
|
K
|
130 |
S
|
K
|
N
|
T
|
G
|
S
|
K
|
T
|
H
|
T
|
140 |
L
|
G
|
V
|
L
|
S
|
E
|
F
|
K
|
S
|
K
|
150 |
E
|
E
|
V
|
A
|
K
|
G
|
A
|
T
|
K
|
L
|
160 |
L
|
R
|
K
|
V
|
E
|
H
|
H
|
I
|
L
|
N
|
170 |
E
|
N
|
S
|
D
|
I
|
P
|
K
|
K
|
D
|
E
|
180 |
N
|
P
|
L
|
L
|
D
|
I
|
V
|
Y
|
E
|
T
|
190 |
K
|
R
|
C
|
K
|
T
|
M
|
T
|
L
|
L
|
E
|
200 |
A
|
G
|
N
|
N
|
T
|
M
|
K
|
V
|
D
|
C
|
210 |
T
|
S
|
G
|
F
|
K
|
E
|
H
|
N
|
S
|
G
|
220 |
G
|
E
|
T
|
A
|
V
|
A
|
F
|
I
|
A
|
Y
|
230 |
K
|
S
|
L
|
G
|
N
|
L
|
L
|
N
|
G
|
S
|
240 |
F
|
F
|
S
|
N
|
E
|
E
|
G
|
F
|
Q
|
E
|
250 |
V
|
T
|
L
|
N
|
S
|
H
|
I
|
V
|
S
|
G
|
260 |
A
|
I
|
R
|
S
|
E
|
V
|
K
|
P
|
V
|
L
|
270 |
S
|
E
|
P
|
V
|
L
|
L
|
T
|
L
|
Q
|
N
|
280 |
I
|
Q
|
P
|
I
|
D
|
S
|
R
|
A
|
E
|
H
|
290 |
L
|
C
|
V
|
H
|
W
|
E
|
G
|
S
|
E
|
E
|
300 |
G
|
G
|
S
|
W
|
S
|
T
|
K
|
G
|
C
|
S
|
310 |
H
|
V
|
Y
|
T
|
N
|
N
|
S
|
Y
|
T
|
I
|
320 |
C
|
K
|
C
|
F
|
H
|
L
|
S
|
S
|
F
|
A
|
330 |
V
|
L
|
M
|
A
|
L
|
P
|
H
|
E
|
E
|
D
|
340 |
TM1 | |||||||||
G
|
V
|
L
|
S
|
A
|
L
|
S
|
V
|
I
|
T
|
350 |
Y
|
V
|
G
|
L
|
S
|
L
|
S
|
L
|
L
|
C
|
360 |
L
|
F
|
L
|
A
|
A
|
I
|
T
|
F
|
L
|
L
|
370 |
ICL1 | TM2 | ||||||||
C
|
R
|
P
|
I
|
Q
|
N
|
T
|
S
|
T
|
T
|
380 |
L
|
H
|
L
|
Q
|
L
|
S
|
I
|
C
|
L
|
F
|
390 |
L
|
A
|
D
|
L
|
L
|
F
|
L
|
T
|
G
|
I
|
400 |
ECL1 | TM3 | ||||||||
N
|
R
|
T
|
K
|
P
|
K
|
V
|
L
|
C
|
S
|
410 |
I
|
I
|
A
|
G
|
M
|
L
|
H
|
Y
|
L
|
Y
|
420 |
L
|
A
|
S
|
F
|
M
|
W
|
M
|
F
|
L
|
E
|
430 |
G
|
L
|
H
|
L
|
F
|
L
|
T
|
V
|
S
|
N
|
440 |
ICL2 | |||||||||
L
|
K
|
V
|
A
|
N
|
Y
|
S
|
N
|
S
|
G
|
450 |
TM4 | |||||||||
R
|
F
|
K
|
K
|
R
|
F
|
M
|
Y
|
P
|
V
|
460 |
G
|
Y
|
G
|
L
|
P
|
A
|
F
|
I
|
V
|
A
|
470 |
ECL2 | |||||||||
V
|
S
|
A
|
I
|
A
|
G
|
H
|
K
|
N
|
Y
|
480 |
G
|
T
|
H
|
N
|
H
|
C
|
W
|
L
|
S
|
L
|
490 |
TM5 | |||||||||
H
|
R
|
G
|
F
|
I
|
W
|
S
|
F
|
L
|
G
|
500 |
P
|
A
|
A
|
A
|
I
|
I
|
L
|
I
|
N
|
L
|
510 |
V
|
F
|
Y
|
F
|
L
|
I
|
I
|
W
|
I
|
L
|
520 |
R
|
S
|
K
|
L
|
S
|
S
|
L
|
N
|
K
|
E
|
530 |
ICL3 | TM6 | ||||||||
V
|
S
|
T
|
L
|
Q
|
D
|
T
|
K
|
V
|
M
|
540 |
T
|
F
|
K
|
A
|
I
|
V
|
Q
|
L
|
F
|
V
|
550 |
L
|
G
|
C
|
S
|
W
|
G
|
I
|
G
|
L
|
F
|
560 |
ECL3 | |||||||||
I
|
F
|
I
|
E
|
V
|
G
|
K
|
T
|
V
|
R
|
570 |
TM7 | |||||||||
L
|
I
|
V
|
A
|
Y
|
L
|
F
|
T
|
I
|
I
|
580 |
N
|
V
|
L
|
Q
|
G
|
V
|
L
|
I
|
F
|
M
|
590 |
H8 | |||||||||
V
|
H
|
C
|
L
|
L
|
N
|
R
|
Q
|
V
|
R
|
600 |
M
|
E
|
Y
|
K
|
K
|
W
|
F
|
H
|
R
|
L
|
610 |
C-term | |||||||||
R
|
K
|
E
|
V
|
E
|
S
|
E
|
S
|
T
|
E
|
620 |
V
|
S
|
H
|
S
|
T
|
T
|
H
|
T
|
K
|
M
|
630 |
G
|
L
|
S
|
L
|
N
|
L
|
E
|
N
|
F
|
C
|
640 |
P
|
T
|
G
|
N
|
L
|
H
|
D
|
P
|
S
|
D
|
650 |
S
|
I
|
L
|
P
|
S
|
T
|
E
|
V
|
A
|
G
|
660 |
V
|
Y
|
L
|
S
|
T
|
P
|
R
|
S
|
H
|
M
|
670 |
G
|
A
|
E
|
D
|
V
|
N
|
S
|
G
|
T
|
H
|
680 |
A
|
Y
|
W
|
S
|
R
|
T
|
I
|
S
|
D
|
LINKS
DIAGRAMS
GAIN domain
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available