GPER (gper1_rat)

FAMILY

Class A (Rhodopsin) Steroid receptors Estrogen (G protein-coupled) receptors GPER

GENE

Gper1 (Cmkrl2, Gper, Gpr30, Gpr41)

ORGANISM

Rat (Rattus norvegicus)

ALT. NAMES

G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, G protein-coupled estrogen receptor 1, G-protein coupled receptor 30, G-protein coupled receptor 41, Membrane estrogen receptor, mER

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
A
A
T
T
P
A
Q
D
V
10
                   
G
V
E
I
Y
L
G
P
V
W
20
                   
P
A
P
S
N
S
T
P
L
A
30
                   
L
N
L
S
L
A
L
R
E
D
40
                   
A
P
G
N
L
T
G
D
L
S
50
TM1              
E
H
Q
Q
Y
V
I
A
L
F
60
                   
L
S
C
L
Y
T
I
F
L
F
70
                   
P
I
G
F
V
G
N
I
L
I
80
                   
L
V
V
N
I
S
F
R
E
K
90
ICL1 TM2      
M
T
I
P
D
L
Y
F
I
N
100
                   
L
A
A
A
D
L
I
L
V
A
110
                   
D
S
L
I
E
V
F
N
L
D
120
  ECL1   TM3  
E
Q
Y
Y
D
I
A
V
L
C
130
                   
T
F
M
S
L
F
L
Q
I
N
140
                   
M
Y
S
S
V
F
F
L
T
W
150
                   
M
S
F
D
R
Y
L
A
L
A
160
  ICL2          
K
A
M
R
C
G
L
F
R
T
170
TM4              
K
H
H
A
R
L
S
C
G
L
180
                   
I
W
M
A
S
V
S
A
T
L
190
            ECL2
V
P
F
T
A
V
H
L
R
H
200
                   
T
E
E
A
C
F
C
F
A
D
210
TM5              
V
R
E
V
Q
W
L
E
V
T
220
                   
L
G
F
I
V
P
F
A
I
I
230
                   
G
L
C
Y
S
L
I
V
R
A
240
        ICL3 TM6
L
I
R
A
H
R
H
R
G
L
250
                 
R
P
R
R
Q
K
A
L
R
M
260
                   
I
F
A
V
V
L
V
F
F
I
270
                   
C
W
L
P
E
N
V
F
I
S
280
                   
V
H
L
L
Q
W
A
Q
P
G
290
ECL3 TM7      
D
T
P
C
K
Q
S
F
R
H
300
                   
A
Y
P
L
T
G
H
I
V
N
310
                   
L
A
A
F
S
N
S
C
L
S
320
              H8  
P
L
I
Y
S
F
L
G
E
T
330
                   
F
R
D
K
L
R
L
Y
V
A
340
  C-term      
Q
K
T
S
L
P
A
L
N
R
350
                   
F
C
H
A
T
L
K
A
V
I
360
                   
P
D
S
T
E
Q
S
D
V
K
370
         
F
S
S
A
V

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 R E K M ICL1ECL1 Q Y Y D I ECL1ICL2 A M R C G L F R ICL2ECL2 H L R H T E E A C F C F A ECL2ICL3 H R H ICL3ECL3 P G D T P C ECL3N-term M A A T T P A Q D V G V E I Y L G P V W P A P S N S T P L A L N L S L A L R E D A P G N L T G D L S N-termC-term K T S L P A L N R F C H A T L K A V I P D S T E Q S D V K F S S A V C-term E H Q Q Y V I A L F L S C L Y T I F L F P I G F V G N I L I L V V N I S F T I P D L Y F I N L A A A D L I L V A D S L I E V F N L D E A V L C T F M S L F L Q I N M Y S S V F F L T W M S F D R Y L A L A K T K H H A R L S C G L I W M A S V S A T L V P F T A V D V R E V Q W L E V T L G F I V P F A I I G L C Y S L I V R A L I R A R G L R P R R Q K A L R M I F A V V L V F F I C W L P E N V F I S V H L L Q W A Q K Q S F R H A Y P L T G H I V N L A A F S N S C L S P L I Y S F L G E T L R L F R D K Y V A Q
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

I N G V F G I P F L F I T Y L C S L F L 1 I N L A A A D L I L V A D S L I E V F N 2 W T L F F V S S Y M N I Q L F L S M F T 3 A R L S C G L I W M A S V S A T L V P F 4 Y C L G I I A F P V I F G L T V E L W Q V 5 F A V V L V F F I C W L P E N V F I S V 6 L P S L C S N S F A A L N V I H G T L 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available