LPA1 receptor (lpar1_mouse)

FAMILY

Class A (Rhodopsin) Lipid receptors Lysophospholipid (LPA) receptors LPA1 receptor

GENE

Lpar1 (Edg2, Gpcr26, Lpa1)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Lysophosphatidic acid receptor 1, LPA receptor 1, LPA-1, Lysophosphatidic acid receptor Edg-2, Rec1.3, VZG-1

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
A
A
A
S
T
S
S
P
V
10
                   
I
S
Q
P
Q
F
T
A
M
N
20
                   
E
Q
Q
C
F
Y
N
E
S
I
30
                   
A
F
F
Y
N
R
S
G
K
Y
40
            TM1  
L
A
T
E
W
N
T
V
S
K
50
                   
L
V
M
G
L
G
I
T
V
C
60
                   
V
F
I
M
L
A
N
L
L
V
70
                   
M
V
A
I
Y
V
N
R
R
F
80
ICL1 TM2      
H
F
P
I
Y
Y
L
M
A
N
90
                   
L
A
A
A
D
F
F
A
G
L
100
                   
A
Y
F
Y
L
M
F
N
T
G
110
ECL1     TM3  
P
N
T
R
R
L
T
V
S
T
120
                   
W
L
L
R
Q
G
L
I
D
T
130
                   
S
L
T
A
S
V
A
N
L
L
140
                   
A
I
A
I
E
R
H
I
T
V
150
    ICL2        
F
R
M
Q
L
H
T
R
M
S
160
TM4              
N
R
R
V
V
V
V
I
V
V
170
                   
I
W
T
M
A
I
V
M
G
A
180
          ECL2  
I
P
S
V
G
W
N
C
I
C
190
                   
D
I
D
H
C
S
N
M
A
P
200
    TM5          
L
Y
S
D
S
Y
L
V
F
W
210
                   
A
I
F
N
L
V
T
F
V
V
220
                   
M
V
V
L
Y
A
H
I
F
G
230
                   
Y
V
R
Q
R
T
M
R
M
S
240
ICL3 TM6      
R
H
S
S
G
P
R
R
N
R
250
                   
D
T
M
M
S
L
L
K
T
V
260
                   
V
I
V
L
G
A
F
I
V
C
270
                   
W
T
P
G
L
V
L
L
L
L
280
        ECL3 TM7
D
V
C
C
P
Q
C
D
V
L
290
                 
A
Y
E
K
F
F
L
L
L
A
300
                   
E
F
N
S
A
M
N
P
I
I
310
        H8        
Y
S
Y
R
D
K
E
M
S
A
320
                   
T
F
R
Q
I
L
C
C
Q
R
330
C-term        
N
E
N
P
N
G
P
T
E
G
340
                   
S
D
R
S
A
S
S
L
N
H
350
                   
T
I
L
A
G
V
H
S
N
D
360
       
H
S
V
V

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 R R F H ICL1ECL1 T G P N T R R L ECL1ICL2 M Q L H T R M ICL2ECL2 W N C I C D I D H C S N M A P L Y ECL2ICL3 R H S S ICL3ECL3 P Q C ECL3N-term M A A A S T S S P V I S Q P Q F T A M N E Q Q C F Y N E S I A F F Y N R S G K Y L A T E W N N-termC-term C Q R N E N P N G P T E G S D R S A S S L N H T I L A G V H S N D H S V V C-term T V S K L V M G L G I T V C V F I M L A N L L V M V A I Y V N F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R S N R R V V V V I V V I W T M A I V M G A I P S V G S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M S G P R R N R D T M M S L L K T V V I V L G A F I V C W T P G L V L L L L D V C C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E F R Q M S A T I L C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N A L M I F V C V T I G L G M V L K S 1 A N L A A A D F F A G L A Y F Y L M F N 2 A L L N A V S A T L S T D I L G Q R L L 3 V V V V I V V I W T M A I V M G A I P S 4 Y L V V M V V F T V L N F I A W F V L Y 5 V I V L G A F I V C W T P G L V L L L L 6 I P N M A S N F E A L L L F F K E Y A 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

LPA, 1-O-Oleoyl-D-glycerol 3-phosphoric acid, LYSOPHOSPHATIDIC ACID

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available