DP2 receptor (pd2r2_mouse)

FAMILY

Class A (Rhodopsin) Lipid receptors Prostanoid receptors DP2 receptor

GENE

Ptgdr2 (Crth2, Gpr44)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Prostaglandin D2 receptor 2, Chemoattractant receptor-homologous molecule expressed on Th2 cells, G-protein coupled receptor 44, CD294

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
A
N
V
T
L
K
P
L
C
10
                   
P
L
L
E
E
M
V
Q
L
P
20
                   
N
H
S
N
S
S
L
R
Y
I
30
TM1              
D
H
V
S
V
L
L
H
G
L
40
                   
A
S
L
L
G
L
V
E
N
G
50
                   
L
I
L
F
V
V
G
C
R
M
60
ICL1 TM2      
R
Q
T
V
V
T
T
W
V
L
70
                   
H
L
A
L
S
D
L
L
A
A
80
                   
A
S
L
P
F
F
T
Y
F
L
90
      ECL1      
A
V
G
H
S
W
E
L
G
T
100
TM3              
T
F
C
K
L
H
S
S
V
F
110
                   
F
L
N
M
F
A
S
G
F
L
120
                   
L
S
A
I
S
L
D
R
C
L
130
        ICL2    
Q
V
V
R
P
V
W
A
Q
N
140
    TM4          
H
R
T
V
A
V
A
H
R
V
150
                   
C
L
M
L
W
A
L
A
V
L
160
                   
N
T
I
P
Y
F
V
F
R
D
170
ECL2            
T
I
P
R
L
D
G
R
I
M
180
                   
C
Y
Y
N
L
L
L
W
N
P
190
    TM5          
G
P
D
R
D
T
T
C
D
Y
200
                   
R
Q
K
A
L
A
V
S
K
F
210
                   
L
L
A
F
M
V
P
L
A
I
220
                   
I
A
S
S
H
V
A
V
S
L
230
          ICL3  
R
L
H
H
R
G
R
Q
R
T
240
TM6              
G
R
F
V
R
L
V
A
A
I
250
                   
V
V
A
F
V
L
C
W
G
P
260
                   
Y
H
I
F
S
L
L
E
A
R
270
  ECL3   TM7  
A
H
S
V
T
T
L
R
Q
L
280
                   
A
S
R
G
L
P
F
V
T
S
290
                   
L
A
F
F
N
S
V
V
N
P
300
            H8    
L
L
Y
V
F
T
C
P
D
M
310
                   
L
Y
K
L
R
R
S
L
R
A
320
        C-term
V
L
E
S
V
L
V
E
D
S
330
                   
D
Q
S
G
G
L
R
N
R
R
340
                   
R
R
A
S
S
T
A
T
P
A
350
                   
S
T
L
L
L
A
D
R
I
P
360
                   
Q
L
R
P
T
R
L
I
G
W
370
                   
M
R
R
G
S
A
E
V
P
Q
380
   
R
V

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 M R Q ICL1ECL1 H S W E L ECL1ICL2 P V W A Q N H R ICL2ECL2 D T I P R L D G R I M C Y Y N L L L W N P G P ECL2ICL3 G R Q R ICL3ECL3 H S V T T ECL3N-term M A N V T L K P L C P L L E E M V Q L P N H S N S S L R Y I N-termC-term V L V E D S D Q S G G L R N R R R R A S S T A T P A S T L L L A D R I P Q L R P T R L I G W M R R G S A E V P Q R V C-term D H V S V L L H G L A S L L G L V E N G L I L F V V G C R T V V T T W V L H L A L S D L L A A A S L P F F T Y F L A V G G T T F C K L H S S V F F L N M F A S G F L L S A I S L D R C L Q V V R T V A V A H R V C L M L W A L A V L N T I P Y F V F R D R D T T C D Y R Q K A L A V S K F L L A F M V P L A I I A S S H V A V S L R L H H R T G R F V R L V A A I V V A F V L C W G P Y H I F S L L E A R A L R Q L A S R G L P F V T S L A F F N S V V N P L L Y V F T C P D L R R V L E M L Y K S L R A S
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N E V L G L L S A L G H L L V S V H D 1 L H L A L S D L L A A A S L P F F T Y F 2 A S L L F G S A F M N L F F V S S H L K 3 A H R V C L M L W A L A V L N T I P Y 4 H S S A I I A L P V M F A L L F K S V A L 5 A A I V V A F V L C W G P Y H I F S L L 6 L P N V V S N F F A L S T V F P L G R 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

PGF2α, PGJ2, PGD2, PGE2, PGD3

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available