GPR65 (psyr_mouse)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR65
GENE
Gpr65 (Gpcr25, Tdag8)
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Psychosine receptor, G-protein coupled receptor 65, T-cell death-associated gene 8 protein
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
M
|
N
|
S
|
M
|
C
|
I
|
E
|
E
|
10 |
TM1 | |||||||||
Q
|
H
|
H
|
L
|
E
|
H
|
Y
|
L
|
F
|
P
|
20 |
V
|
V
|
Y
|
I
|
I
|
V
|
F
|
I
|
V
|
S
|
30 |
V
|
P
|
A
|
N
|
I
|
G
|
S
|
L
|
C
|
V
|
40 |
ICL1 | |||||||||
S
|
F
|
L
|
Q
|
A
|
K
|
K
|
E
|
N
|
E
|
50 |
TM2 | |||||||||
L
|
G
|
I
|
Y
|
L
|
F
|
S
|
L
|
S
|
L
|
60 |
S
|
D
|
L
|
L
|
Y
|
A
|
L
|
T
|
L
|
P
|
70 |
L
|
W
|
I
|
N
|
Y
|
T
|
W
|
N
|
K
|
D
|
80 |
ECL1 | TM3 | ||||||||
N
|
W
|
T
|
F
|
S
|
P
|
T
|
L
|
C
|
K
|
90 |
G
|
S
|
V
|
F
|
F
|
T
|
Y
|
M
|
N
|
F
|
100 |
Y
|
S
|
S
|
T
|
A
|
F
|
L
|
T
|
C
|
I
|
110 |
A
|
L
|
D
|
R
|
Y
|
L
|
A
|
V
|
V
|
Y
|
120 |
ICL2 | |||||||||
P
|
L
|
K
|
F
|
S
|
F
|
L
|
R
|
T
|
R
|
130 |
TM4 | |||||||||
R
|
F
|
A
|
F
|
I
|
T
|
S
|
L
|
S
|
I
|
140 |
W
|
I
|
L
|
E
|
S
|
F
|
F
|
N
|
S
|
M
|
150 |
ECL2 | |||||||||
L
|
L
|
W
|
K
|
D
|
E
|
T
|
S
|
V
|
E
|
160 |
Y
|
C
|
D
|
S
|
D
|
K
|
S
|
N
|
F
|
T
|
170 |
TM5 | |||||||||
L
|
C
|
Y
|
D
|
K
|
Y
|
P
|
L
|
E
|
K
|
180 |
W
|
Q
|
I
|
N
|
L
|
N
|
L
|
F
|
R
|
T
|
190 |
C
|
M
|
G
|
Y
|
A
|
I
|
P
|
L
|
I
|
T
|
200 |
I
|
M
|
I
|
C
|
N
|
H
|
K
|
V
|
Y
|
R
|
210 |
ICL3 | |||||||||
A
|
V
|
R
|
H
|
N
|
Q
|
A
|
T
|
E
|
N
|
220 |
TM6 | |||||||||
S
|
E
|
K
|
R
|
R
|
I
|
I
|
K
|
L
|
L
|
230 |
A
|
S
|
I
|
T
|
L
|
T
|
F
|
V
|
L
|
C
|
240 |
F
|
T
|
P
|
F
|
H
|
V
|
M
|
V
|
L
|
I
|
250 |
R
|
C
|
V
|
L
|
E
|
R
|
D
|
M
|
N
|
V
|
260 |
TM7 | |||||||||
N
|
D
|
K
|
S
|
G
|
W
|
Q
|
T
|
F
|
T
|
270 |
V
|
Y
|
R
|
V
|
T
|
V
|
A
|
L
|
T
|
S
|
280 |
L
|
N
|
C
|
V
|
A
|
D
|
P
|
I
|
L
|
Y
|
290 |
H8 | |||||||||
C
|
F
|
V
|
T
|
E
|
T
|
G
|
R
|
A
|
D
|
300 |
M
|
W
|
N
|
I
|
L
|
K
|
L
|
C
|
T
|
R
|
310 |
C-term | |||||||||
K
|
H
|
N
|
R
|
H
|
Q
|
G
|
Q
|
K
|
R
|
320 |
D
|
I
|
L
|
S
|
V
|
S
|
T
|
R
|
D
|
A
|
330 |
V
|
E
|
L
|
E
|
I
|
I
|
D
|
LINKS
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available