GPCRdb

GPCRdb offers:

  • Reference data
  • Analysis tools
  • Visualization
  • Experiment design
  • Data deposition
  • References


G protein-coupled receptors (GPCRs) are cell-surface receptors mediating the responses of 2/3rds of human hormones1 and 1/3rd of drugs2. Each GPCR can bind several transducers, G proteins, GPCR kinases (GRKs) and arrestins leading to distinct intracellular signaling networks and functional outcomes.

Data

  • 805 Human proteins
  • 42,014 Species orthologs
  • 3,013 Generic residues
  • 1,650 GPCR structures
  • 861 Refined structures
  • 1,601 GPCR structure models
  • 633 Physiological ligand-GPCR structure models
  • 968 Drugs
  • 175 Drug targets
  • 405 Disease indications
  • 219,380 Ligands
  • 527 Physiological ligands
  • 489,695 Ligand bioactivities
  • 36,016 Ligand site mutations
  • 64,742 Ligand interactions

Latest release

Dec. 20, 2024
  • GAIN domain segments for Class B2 (Adhesion) GPCRs
  • New structures
  • Minor bug and performance fixes

All releases

Publications

Latest GPCRdb article

GPCRdb in 2025: adding odorant receptors, data mapper, structure similarity search and models of physiological ligand complexes.
Nucleic Acids Research, 2024

Structure analysis platform

An online GPCR structure analysis platform.
Nature Structural & Molecular Biology, 2021

Drug resource

Trends in GPCR drug discovery: new agents, targets and indications.
Nature Reviews Drug Discovery, 2017

Generic residue numbers

Generic GPCR residue numbers - aligning topology maps while minding the gaps.
Trends in pharmacological sciences, 2015

Related resources

GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases.

External GPCR sites