Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

2YDO

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE10136

PUBLICATION DATE

May 18, 2011

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
adenosine F168 45.52x52 ECL2 aromatic (face-to-face)
adenosine E169 ECL2 polar (charge-assisted hydrogen bond)
adenosine M177 5.38x40 TM5 Van der Waals
adenosine W246 6.48x48 TM6 Van der Waals
adenosine W246 6.48x48 TM6 hydrophobic
adenosine L249 6.51x51 TM6 Van der Waals
adenosine L249 6.51x51 TM6 hydrophobic
adenosine N253 6.55x55 TM6 polar (hydrogen bond)
adenosine M270 7.35x34 TM7 Van der Waals
adenosine I274 7.39x38 TM7 hydrophobic
adenosine I274 7.39x38 TM7 Van der Waals
adenosine S277 7.42x41 TM7 polar (hydrogen bond)
adenosine S277 7.42x41 TM7 Van der Waals
adenosine H278 7.43x42 TM7 polar (hydrogen bond)
adenosine H278 7.43x42 TM7 Van der Waals

Ligands

adenosine

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x34 7.35x34 M270
7x38 7.39x38 I274
7x41 7.42x41 S277
7x42 7.43x42 H278