Structure information

H1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

3RZE

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

A

PUBLICATION DATE

June 15, 2011

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Doxepin D107 3.32x32 TM3 polar (charge-charge)
Doxepin Y108 3.33x33 TM3 aromatic (edge-to-face)
Doxepin T112 3.37x37 TM3 polar (hydrogen bond)
Doxepin W158 4.56x57 TM4 aromatic (face-to-edge)
Doxepin W428 6.48x48 TM6 aromatic (face-to-edge)
Doxepin Y431 6.51x51 TM6 hydrophobic
Doxepin F432 6.52x52 TM6 aromatic (edge-to-face)
Doxepin F435 6.55x55 TM6 aromatic (face-to-edge)

Ligands

Doxepin

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Residue Diagrams

L N L G V T V L C I T S L V V V L P 1 V S L S V A D L I V G V A V M P M N I L Y 2 I F V S F I S A T S A V Y D M S L W F L 3 A S A T I L G A W F L S F L W V I P I 4 Y F W L M L L T P L Y F N I I A T M V K F 5 G F I M A A F I L C W I P Y F I F F M V 6 L P N L T S N I Y G L W I T F M H L H 7
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ICL1 R K L H ICL1ECL1 S K W S L ECL1ICL2 P L R Y L K Y R ICL2ECL2 W N H F M Q Q T S V R R E D K C E T D F Y D ECL2ICL3 R S L P S F S E I K L R P E N P K G D A K K P G K E S P W E V L K R K P K D A G G G S V L K S P S Q T P K E M K S P V V F S Q E D D R E V D K L Y C F P L D I V H M Q A A A E G S S R D Y V A V N R S H G Q L K T D E Q G L N T H G A S E I S E D Q M L G D S Q S F S R T D S D T T T E T A P G K G K L R S G S N T G L D Y I K F T W K R L R S H S R Q Y V S ICL3ECL3 K N C C ECL3N-term M S L P N S S C L L E D K M C E G N K T T M A S P Q L M N-termC-term I R S C-term P L V V V L S T I C L V T V G L N L L V L Y A V R S E T V G N L Y I V S L S V A D L I V G A V V M P M N I L Y L L M G R P L C L F W L S M D Y V A S T A S I F S V F I L C I D R Y R S V Q Q T K T R A S A T I L G A W F L S F L W V I P I L G V T W F K V M T A I I N F Y L P T L L M L W F Y A K I Y K A V R Q H C Q H R E L I N G L H M N R E R K A A K Q L G F I M A A F I L C W I P Y F I F F M V I A F C N E H L H M F T I W L G Y I N S T L N P L I Y P L C N E N F K R F K K T I L H
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Residue Table


GPCRdb(A)
GPCRdb(A)
H1 receptor
TM3
3x32 3.32x32 D107
3x33 3.33x33 Y108
3x37 3.37x37 T112
TM4
4x57 4.56x57 W158
TM6
6x48 6.48x48 W428
6x51 6.51x51 Y431
6x52 6.52x52 F432
6x55 6.55x55 F435