Structure information

S1P1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

3V2Y

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

A

PUBLICATION DATE

Feb. 15, 2012

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid Y29 N-term polar (hydrogen bond)
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid K34 N-term polar (charge-charge)
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid N101 2.60x60 TM2 polar (charge-assisted hydrogen bond)
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid R120 3.28x28 TM3 polar (charge-charge)
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid E121 3.29x29 TM3 polar (charge-assisted hydrogen bond)
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid E121 3.29x29 TM3 polar (charge-charge)
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid E121 3.29x29 TM3 polar (charge-charge)
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid M124 3.32x32 TM3 hydrophobic
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid F125 3.33x33 TM3 hydrophobic
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid L128 3.36x36 TM3 hydrophobic
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid V194 ECL2 polar (hydrogen bond with backbone)
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid W269 6.48x48 TM6 hydrophobic
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid L276 6.55x55 TM6 hydrophobic
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid L297 7.39x38 TM7 hydrophobic

Ligands

(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid

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Residue Diagrams

I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7
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ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
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Residue Table


GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM2
2x60 2.60x60 N101
TM3
3x28 3.28x28 R120
3x29 3.29x29 E121
3x32 3.32x32 M124
3x33 3.33x33 F125
3x36 3.36x36 L128
TM6
6x48 6.48x48 W269
6x55 6.55x55 L276
TM7
7x38 7.39x38 L297