Structure information

PAR1

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

3VW7

SPECIES

Homo sapiens

RESOLUTION

2.200

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE11701

PUBLICATION DATE

Dec. 12, 2012

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
vorapaxar Y183 3.33x33 TM3 aromatic (face-to-edge)
vorapaxar L237 4.60x61 TM4 hydrophobic
vorapaxar V257 ECL2 polar (hydrogen bond with backbone)
vorapaxar V257 ECL2 Van der Waals
vorapaxar L258 ECL2 Van der Waals
vorapaxar L258 ECL2 polar (hydrogen bond with backbone)
vorapaxar L262 ECL2 Van der Waals
vorapaxar L262 ECL2 hydrophobic
vorapaxar L263 ECL2 hydrophobic
vorapaxar F271 5.39x39 TM5 Van der Waals
vorapaxar F271 5.39x39 TM5 hydrophobic
vorapaxar L332 6.54x54 TM6 hydrophobic
vorapaxar L332 6.54x54 TM6 Van der Waals
vorapaxar L333 6.55x55 TM6 hydrophobic
vorapaxar L333 6.55x55 TM6 Van der Waals
vorapaxar H336 6.58x58 TM6 Van der Waals
vorapaxar Y337 6.59x59 TM6 aromatic (edge-to-face)
vorapaxar Y337 6.59x59 TM6 Van der Waals
vorapaxar Y337 6.59x59 TM6 polar (hydrogen bond)
vorapaxar S344 ECL3 Van der Waals
vorapaxar A349 7.31x30 TM7 Van der Waals
vorapaxar A349 7.31x30 TM7 polar (hydrogen bond with backbone)
vorapaxar Y350 7.32x31 TM7 Van der Waals
vorapaxar Y350 7.32x31 TM7 hydrophobic
vorapaxar Y353 7.35x34 TM7 Van der Waals
vorapaxar Y353 7.35x34 TM7 hydrophobic

Ligands

vorapaxar

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Residue Diagrams

I N L P L S V V F V G T Y V S P V F L T 1 L H L A T A D V L F V S V L P F K I S Y 2 V T M L L I S A Y M N C Y F A A T V F R 3 A S F T C L A I W A L A I A G V V P L 4 Y C V T S I I L P V F F F V A S F A S F 5 S A A V F C I F I I C F G P T N V L L I A 6 L P D I C C S I S S V C V C L L Y A F 7
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ICL1 M K V K ICL1ECL1 G S D W Q F ECL1ICL2 P M Q S L S W R ICL2ECL2 E Q T I Q V P G L N I T T C H D V L N E T L L ECL2ICL3 S A V A ICL3ECL3 S H T S T ECL3N-term M G P R R L L L V A A C F S L C G P L L S A R T R A R R P E S K A T N A T L D P R S F L L R N P N D K Y E P F W E D E E K N E S G L T E Y R L V S I N K S S P L Q K Q L P A F I S E D A S G Y L T S N-termC-term E S S D P S S Y N S S G Q L M A S K M D T C S S N L N N S I Y K K L L T C-term S W L T L F V P S V Y T G V F V V S L P L N I M A I V V F I L K K P A V V Y M L H L A T A D V L F V S V L P F K I S Y Y F S G S E L C R F V T A A F Y C N M Y A S I L L M T V I S I D R F L A V V Y T L G R A S F T C L A I W A L A I A G V V P L L L K E G Y Y A Y Y F S A F S A V F F F V P L I I S T V C Y V S I I R C L S S N R S K K S R A L F L S A A V F C I F I I C F G P T N V L L I A H Y S F L T E A A Y F A Y L L C V C V S S I S C C I D P L I Y Y Y A S S E V Y S K C Q R Y I L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
PAR1
TM3
3x33 3.33x33 Y183
TM4
4x61 4.60x61 L237
TM5
5x39 5.39x39 F271
TM6
6x54 6.54x54 L332
6x55 6.55x55 L333
6x58 6.58x58 H336
6x59 6.59x59 Y337
TM7
7x30 7.31x30 A349
7x31 7.32x31 Y350
7x34 7.35x34 Y353