Structure information

P2Y12 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4PXZ

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

PUBLICATION DATE

April 30, 2014

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
2MeSADP R93 3.21x21 TM3 polar (charge-assisted hydrogen bond)
2MeSADP C97 3.25x25 TM3 polar (hydrogen bond with backbone)
2MeSADP V102 3.30x30 TM3 hydrophobic
2MeSADP Y105 3.33x33 TM3 polar (hydrogen bond)
2MeSADP N159 4.60x60 TM4 polar (hydrogen bond)
2MeSADP N159 4.60x60 TM4 polar (hydrogen bond)
2MeSADP C175 45.50x50 ECL2 polar (hydrogen bond with backbone)
2MeSADP K179 ECL2 polar (charge-assisted hydrogen bond)
2MeSADP K179 ECL2 polar (charge-assisted hydrogen bond)
2MeSADP H187 5.36x36 TM5 polar (hydrogen bond)
2MeSADP V190 5.39x39 TM5 hydrophobic
2MeSADP N191 5.40x40 TM5 polar (hydrogen bond)
2MeSADP N191 5.40x40 TM5 polar (hydrogen bond)
2MeSADP N191 5.40x40 TM5 polar (hydrogen bond)
2MeSADP R256 6.55x55 TM6 polar (charge-assisted hydrogen bond)
2MeSADP R256 6.55x55 TM6 polar (charge-charge)
2MeSADP Y259 6.58x58 TM6 polar (charge-assisted hydrogen bond)
2MeSADP Q263 6.62x62 TM6 polar (charge-assisted hydrogen bond)
2MeSADP Q263 6.62x62 TM6 polar (hydrogen bond)
2MeSADP K280 7.35x34 TM7 polar (charge-assisted hydrogen bond)
2MeSADP K280 7.35x34 TM7 polar (charge-charge)

Ligands

2MeSADP

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Residue Diagrams

G N T I L G V F F L V T Y L L P F L V Q 1 K N T V I S D L L M I L T F P F K I L S 2 L G L F S I S I Y M T F Y F I V S T V Q 3 A K I L S V V I W A F M F L L S L P N M 4 Y C V I V I L F N I W F I V Q C I Y N V 5 V F I I I A V F I F C F V P F H F A R I P 6 F P D L C A N L S T L W L T S E K V Y 7
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ICL1 R S K ICL1ECL1 L G T ECL1ICL2 P F K T S N P K ICL2ECL2 N R Q P R D K N V K K C S F L K S ECL2ICL3 R G V G K V ICL3ECL3 D V F ECL3N-term M Q A V D N L T S A P G N T S L C T R D N-termC-term L K C P N S A T S L S Q D N R K K E Q D G G D P N E E T P M C-term Y K I T Q V L F P L L Y T V L F F V G L I T N G L A M R I F F Q I S N F I I F L K N T V I S D L L M I L T F P F K I L S D A K G P L R T F V C Q V T S V I F Y F T M Y I S I S F L G L I T I D R Y Q K T T R N L L G A K I L S V V I W A F M F L L S L P N M I L T E F G L V W H E I V N Y I C Q V I F W I N F L I V I V C Y T L I T K E L Y R S Y V R T P R K K V N V K V F I I I A V F F I C F V P F H F A R I P Y T L S Q T R D C T A E N T L F Y V K E S T L W L T S L N A C L D P F I Y F F L C K S L I S F R N S M
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Residue Table


GPCRdb(A)
GPCRdb(A)
P2Y12 receptor
TM3
3x21 3.21x21 R93
3x25 3.25x25 C97
3x30 3.30x30 V102
3x33 3.33x33 Y105
TM4
4x60 4.60x60 N159
ECL2
45x50 45.50x50 C175
TM5
5x36 5.36x36 H187
5x39 5.39x39 V190
5x40 5.40x40 N191
TM6
6x55 6.55x55 R256
6x58 6.58x58 Y259
6x62 6.62x62 Q263
TM7
7x34 7.35x34 K280